alosetron

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/05 13:40:44」(JST)

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英文文献

  • Application of a UPLC-MS/MS method for the analysis of alosetron in human plasma to support a bioequivalence study in healthy males and females.
  • Chaudhary DV1, Patel DP, Shah JV, Shah PA, Sanyal M, Shrivastav PS.
  • Biomedical chromatography : BMC.Biomed Chromatogr.2015 Mar 11. doi: 10.1002/bmc.3454. [Epub ahead of print]
  • A simple, rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the determination of alosetron (ALO) in human plasma. The assay method involved solid-phase extraction of ALO and ALO 13C-d3 as internal standard (I
  • PMID 25761551
  • Metabolic kinetics of 5-hydroxytryptamine and the research targets of functional gastrointestinal disorders.
  • Jing F1, Zhang J.
  • Digestive diseases and sciences.Dig Dis Sci.2014 Nov;59(11):2642-8. doi: 10.1007/s10620-014-3244-x. Epub 2014 Jun 12.
  • 5-Hydroxytryptamine (5-HT) is an important neurotransmitter in both the central and enteric nervous systems. It has diverse functions in regulating gastrointestinal motility and visceral sensitivity, emotion, appetite, pain and sensory perception, cognition, sexual activity and sleep. These function
  • PMID 24916714
  • Treatment of abdominal pain in irritable bowel syndrome.
  • Vanuytsel T1, Tack JF, Boeckxstaens GE.
  • Journal of gastroenterology.J Gastroenterol.2014 Aug;49(8):1193-205. doi: 10.1007/s00535-014-0966-7. Epub 2014 May 21.
  • Functional abdominal pain in the context of irritable bowel syndrome (IBS) is a challenging problem for primary care physicians, gastroenterologists and pain specialists. We review the evidence for the current and future non-pharmacological and pharmacological treatment options targeting the central
  • PMID 24845149

和文文献

  • Effects of TAK-480, a Novel Tachykinin NK_2-Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid-Induced Defecation in Guinea Pigs
  • Tanaka Takahiro,Tanaka Akiko,Nakamura Akihiro [他],MATSUSHITA Kozo,IMANISHI Akio,MATSUMOTO OKANO Shiho,INATOMI Nobuhiro,MIURA Kasei,TOYODA Masao,MIZOJIRI Gaku,TSUKIMI Yasuhiro
  • Journal of pharmacological sciences 120(1), 15-25, 2012-09-20
  • … In a rabbit model of intracolonic zymosan-induced visceral hypersensitivity, TAK-480 markedly inhibited the visceromotor response to colorectal distension, in contrast to the moderate inhibition by the serotonin 5-HT<SUB>3</SUB>–receptor antagonist alosetron. … In addition, TAK-480 suppressed ricinoleic acid<I>–</I>induced defecation without affecting spontaneous defecation in guinea pigs, whereas alosetron suppressed both. …
  • NAID 10031071815
  • Evaluation of the Pharmacological Profile of Ramosetron, a Novel Therapeutic Agent for Irritable Bowel Syndrome
  • Hirata Takuya,Keto Yoshihiro,Funatsu Toshiyuki [他],AKUZAWA Shinobu,SASAMATA Masao
  • Journal of pharmacological sciences 104(3), 263-273, 2007-07-20
  • … We examined the pharmacological profile of ramosetron, a 5-HT3-receptor antagonist for irritable bowel syndrome with diarrhea, comparing it with those of other 5-HT3-receptor antagonists, alosetron and cilansetron, and the anti-diarrheal agent loperamide. … Dissociation of ramosetron from the human 5-HT3 receptor was extremely slow (t1/2 = 560 min), while alosetron (t1/2 = 180 min) and cilansetron (t1/2 = 88 min) dissociated relatively rapidly. …
  • NAID 10024314859
  • Novelty Stress Increases Fecal Pellet Output in Mongolian Gerbils : Effects of Several Drugs
  • Okano Shiho,Nagaya Hideaki,Inatomi Nobuhiro
  • Journal of pharmacological sciences 98(4), 411-418, 2005-08-20
  • … Drugs reportedly effective for stress-induced defecation, like alosetron hydrochloride, atropine sulfate, and trimebutine maleate, inhibited both the novelty stress-induced increase in fecal pellet output and spontaneous defecation. …
  • NAID 10025729637

関連リンク

Alosetron is used to treat diarrhea, pain, cramps, and the feeling of an urgent need to have bowel movements caused by irritable bowel syndrome (IBS; a condition that causes stomach pain, bloating, constipation, and ...
Alosetron - Alosetron blocks the action of a chemical called serotonin in the intestines. This slows the movement of stools (bowel movements) through the intestines. - Alosetron is available only under a special program called the ...

関連画像

Drugs reference index « Lotronex »Alosetron belongs to a class of drugs Description Alosetron.svgAlosetron Structural Formulae V.1.svg alosetron hcl,alosetron drug,alosetronAlosetron Chemical Structure


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