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English Journal

Walther S1, Rusitzka TV2, Diesterbeck US3, Czerny CP4.
Developmental and comparative immunology.Dev Comp Immunol.2015 Jul 25. pii: S0145-305X(15)30022-7. doi: 10.1016/j.dci.2015.07.017. [Epub ahead of print]
Our understanding of how equine immunoglobulin genes are organized has increased significantly in recent years. For equine heavy chains, 52 IGHV, 40 IGHD, 8 IGHJ and 11 IGHC are present. Seven of these IGHCs are gamma chain genes. Sequence diversity is increasing between fetal, neonatal, foal and ad
PMID 26219564

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays.

Ramond C1, Bandeira A2, Berthault C3, Pereira P3, Cumano A4, Burlen-Defranoux O3.
Journal of visualized experiments : JoVE.J Vis Exp.2015 Jun 9;(100):e52795. doi: 10.3791/52795.
Characterizing thymic settling progenitors is important to understand the pre-thymic stages of T cell development, essential to devise strategies for T cell replacement in lymphopenic patients. We studied thymic settling progenitors from murine embryonic day 13 and 18 thymi by two complementary in v
PMID 26131754

New insights into the DT40 B cell receptor cluster using a proteomic proximity labeling assay.

Li XW1, Rees JS2, Xue P3, Zhang H3, Hamaia SW4, Sanderson B5, Funk PE5, Farndale RW4, Lilley KS2, Perrett S6, Jackson AP7.
The Journal of biological chemistry.J Biol Chem.2014 May 23;289(21):14434-47. doi: 10.1074/jbc.M113.529578. Epub 2014 Apr 4.
In the vertebrate immune system, each B-lymphocyte expresses a surface IgM-class B cell receptor (BCR). When cross-linked by antigen or anti-IgM antibody, the BCR accumulates with other proteins into distinct surface clusters that activate cell signaling, division, or apoptosis. However, the molecul
PMID 24706754

Identification of T cell Peptides from lgG2a^b involved in lgG2a^bT cell-induced allotypic suppression. Relationship with the MHC haplotype of the suppressor T celldonor lgh^a mice.