alloimmuniz ation

出典: meddic


  • CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming.
  • Jiang BH1, Chen WY2,3, Li HY4,5, Chien Y6,7, Chang WC8,9, Hsieh PC2, Wu P6,7, Chen CY2,3, Song HY6, Chien CS1,7, Sung YJ4,10, Chiou SH4,6,11,7,12.
  • Stem cells (Dayton, Ohio).Stem Cells.2015 Oct;33(10):2961-72. doi: 10.1002/stem.2116.
  • PARP1 and poly(ADP-ribosyl)ation (PARylation) have been shown to be essential for the initial steps of cellular reprogramming. However, the mechanism underlying PARP1/PARylation-regulated activation of pluripotency loci remains undetermined. Here, we demonstrate that CHD1L, a DNA helicase, possesses
  • PMID 26201266
  • Differential and concordant roles for PARP1 and poly(ADP-ribose) in regulating WRN and RECQL5 activities.
  • Khadka P1, Hsu JK1, Veith S2, Tadokoro T1, Shamanna R1, Mangerich A2, Croteau DL1, Bohr VA3.
  • Molecular and cellular biology.Mol Cell Biol.2015 Sep 21. pii: MCB.00427-15. [Epub ahead of print]
  • Poly(ADP-ribose) polymerase 1 (PARP1) catalyzes the polyADP(ribosyl)ation (PARylation) of proteins, a post-translational modification which forms the nucleic acid-like polymer poly(ADP-ribose) (PAR). PARP1 and PAR are integral players in the early DNA damage response, since PARylation orchestrates t
  • PMID 26391948
  • [From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy].
  • Schreiber V1, Illuzzi G2, Héberlé E2, Dantzer F2.
  • Bulletin du cancer.Bull Cancer.2015 Sep 15. pii: S0007-4551(15)00243-X. doi: 10.1016/j.bulcan.2015.07.012. [Epub ahead of print]
  • Poly(ADP-ribosyl)ation is a post-translational modification catalyzed by poly(ADP-ribose) polymerases. PARP-1 is a molecular sensor of DNA breaks, playing a key role in the spatial and temporal organization of their repair, contributing to the maintenance of genome integrity and cell survival. The f
  • PMID 26384693


platelet alloimmuniz ation secondary NOS V10 – Personal history of malignant neoplasm V10.5 Urinary organs Excludes personal history of malignant carcinoid tumor (V10.91) and personal history of malignant neuroendocrine ...
... alloimmuniz-ation, infection, the necessity of frequent outpatient follow-up and the time to return to normal quality of life may also depend on the duration of severe thrombocytopenia. Thrombocytopenia-associated bleeding is ...