alloimmuniz ation

English Journal

CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming.

Jiang BH1, Chen WY2,3, Li HY4,5, Chien Y6,7, Chang WC8,9, Hsieh PC2, Wu P6,7, Chen CY2,3, Song HY6, Chien CS1,7, Sung YJ4,10, Chiou SH4,6,11,7,12.
Stem cells (Dayton, Ohio).Stem Cells.2015 Oct;33(10):2961-72. doi: 10.1002/stem.2116.
PARP1 and poly(ADP-ribosyl)ation (PARylation) have been shown to be essential for the initial steps of cellular reprogramming. However, the mechanism underlying PARP1/PARylation-regulated activation of pluripotency loci remains undetermined. Here, we demonstrate that CHD1L, a DNA helicase, possesses
PMID 26201266

Differential and concordant roles for PARP1 and poly(ADP-ribose) in regulating WRN and RECQL5 activities.

Khadka P1, Hsu JK1, Veith S2, Tadokoro T1, Shamanna R1, Mangerich A2, Croteau DL1, Bohr VA3.
Molecular and cellular biology.Mol Cell Biol.2015 Sep 21. pii: MCB.00427-15. [Epub ahead of print]
Poly(ADP-ribose) polymerase 1 (PARP1) catalyzes the polyADP(ribosyl)ation (PARylation) of proteins, a post-translational modification which forms the nucleic acid-like polymer poly(ADP-ribose) (PAR). PARP1 and PAR are integral players in the early DNA damage response, since PARylation orchestrates t
PMID 26391948

Schreiber V1, Illuzzi G2, Héberlé E2, Dantzer F2.
Bulletin du cancer.Bull Cancer.2015 Sep 15. pii: S0007-4551(15)00243-X. doi: 10.1016/j.bulcan.2015.07.012. [Epub ahead of print]
Poly(ADP-ribosyl)ation is a post-translational modification catalyzed by poly(ADP-ribose) polymerases. PARP-1 is a molecular sensor of DNA breaks, playing a key role in the spatial and temporal organization of their repair, contributing to the maintenance of genome integrity and cell survival. The f
PMID 26384693