WordNet

the amount by which the cost of a business exceeds its revenue; "the company operated at a loss last year"; "the company operated in the red last year" (同)red ink, red
gradual decline in amount or activity; "weight loss"; "a serious loss of business"
something that is lost; "the car was a total loss"; "loss of livestock left the rancher bankrupt"
the disadvantage that results from losing something; "his loss of credibility led to his resignation"; "losing him is no great deprivation" (同)deprivation
the act of losing someone or something; "everyone expected him to win so his loss was a shock"
the experience of losing a loved one; "he sympathized on the loss of their grandfather"
of or relating to alleles (同)allelomorphic

PrepTutorEJDIC

〈U〉(…を)『失うこと』,紛失《+『of』+『名』》 / 〈C〉(…の)『損害』,損失;損失額《+『of』+『名』》 / 〈U〉〈C〉(…に)『負けること』,(…の)敗北;失敗《+『of』+『名』》 / 〈U〉(状態・程度の)『減少』,低下 / 《複数形で》(戦場における)(人の)損害,此傷者数
負ける,損をする,勝ち目がない
見よ,そら

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia.

Salaverria I1, Martín-Garcia D1, López C1,2, Clot G1, García-Aragonés M3, Navarro A1, Delgado J4, Baumann T4, Pinyol M5, Martin-Guerrero I2,6, Carrió A1, Costa D1, Queirós AC1, Jayne S7, Aymerich M1, Villamor N1, Colomer D1, González M8, López-Guillermo A4, Campo E1, Dyer MJ7, Siebert R2, Armengol L3, Beà S1.
Genes, chromosomes & cancer.Genes Chromosomes Cancer.2015 Nov;54(11):668-80. doi: 10.1002/gcc.22277. Epub 2015 Aug 25.
Chronic lymphocytic leukemia (CLL) is a common disease with highly variable clinical course. Several recurrent chromosomal alterations are associated with prognosis and may guide risk-adapted therapy. We have developed a targeted genome-wide array to provide a robust tool for ascertaining abnormalit
PMID 26305789

Genetic and epigenetic characterization of low-grade gliomas reveals frequent methylation of the MLH3 gene.

Lhotska H1, Zemanova Z1, Cechova H2, Ransdorfova S3, Lizcova L1, Kramar F4, Krejcik Z2, Svobodova K1, Bystricka D1, Hrabal P4, Dohnalova A5, Michalova K1,3.
Genes, chromosomes & cancer.Genes Chromosomes Cancer.2015 Nov;54(11):655-67. doi: 10.1002/gcc.22266. Epub 2015 Aug 25.
Diffuse astrocytomas and oligodendrogliomas (WHO grade II) are the most common histological subtypes of low-grade gliomas (LGGs). Several molecular and epigenetic markers have been identified that predict tumor progression. Our aim was in detail to investigate the genetic and epigenetic background o
PMID 26303387

Lovvorn HN 3rd1, Pierce J1, Libes J2,3, Li B4, Wei Q4, Correa H5, Gouffon J6, Clark PE7, Axt JR1, Hansen E1, Newton M8, O'Neill JA Jr1; Kenyan Wilms Tumor Consortium.
Genes, chromosomes & cancer.Genes Chromosomes Cancer.2015 Nov;54(11):702-15. doi: 10.1002/gcc.22281. Epub 2015 Aug 14.
Wilms tumor (WT) is the most common childhood kidney cancer worldwide and poses a cancer health disparity to black children of sub-Saharan African ancestry. Although overall survival from WT at 5 years exceeds 90% in developed countries, this pediatric cancer is alarmingly lethal in sub-Saharan Afri
PMID 26274016

リンク元	「ヘテロ接合性欠失」
関連記事	「loss」「allelic」

Loss of heterozygosity (LOH) in a cell represents the loss of normal function of one allele of a gene in which the other allele was already inactivated. This term is mostly used in the context of oncogenesis; after an inactivating mutation in one allele of a tumor suppressor gene occurs in the parent's germline cell, it is passed on to the zygote resulting in an offspring that is heterozygous for that allele. In oncology, loss of heterozygosity occurs when the remaining functional allele in a somatic cell of the offspring becomes inactivated by mutation. This results in no normal tumor suppressor being produced and this could result in tumorigenesis.