無アルブミン血症
WordNet
- a book of blank pages with pockets or envelopes; for organizing photographs or stamp collections etc
- one or more recordings issued together; originally released on 12-inch phonograph records (usually with attractive record covers) and later on cassette audiotape and compact disc (同)record album
- a simple water-soluble protein found in many animal tissues and liquids (同)albumen
PrepTutorEJDIC
- 〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
- (写真・切手・切り抜きなどを貼る)『アルバム』 / (いくつかの曲・劇などを収録した)組レコード,アルバム / 画帳
- アルブミン(蛋白質の一種)
UpToDate Contents
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English Journal
- Hematologic and bone marrow changes in children with protein-energy malnutrition.
- Ozkale M1, Sipahi T.Author information 1Department of Pediatrics, Faculty of Medicine, Baskent University , Adana , Turkey.AbstractBackground: All systems in an organism are affected by protein-energy malnutrition (PEM), but one of the worst affected is the hematopoietic system. Today PEM remains a very serious problem in developing countries. We examined the relationships between clinical features, hematological, and bone marrow changes with severe PEM from Turkey. Method: We evaluated 34 (11 females and 23 males) consecutive cases of severe PEM, with no underlying diseases aged 3-20 months. The clinical nutritional conditions of the patients were determined using the Wellcome-Trust PEM classification. Ten of the patients were in the Marasmic-Kwashiorkor (M-K) group, 10 were in the Kwashiorkor (KW) group, and 14 were in the Marasmic (M) group. Full blood count, protein, albumin, serum iron (SI), iron-binding capacity (TIBC), ferritin, vitamin B12, folic acid, complement-3 (C3), complement-4 (C4), and bone marrow were investigated in all groups. Results: Anemia was detected in 97% of patients. We determined serum iron levels were low in 67.6% of the patients, TS levels were low in 76.4% of the patients and ferritin levels were low in 20.5%. The level of vitamin B12 was normal in all patients. Bone marrow analysis showed erythroid series hypoplasia in 28.5% of patients in the M group, 50% in the KW group, and 30% in the M-K group. Marrow iron was absent in 58.8% of patients. Conclusion: The most common hematologic change in the children with PEM was anemia and major cause of anemia was iron deficiency in this study. Patients with severe PEM have normal Vit B12 and serum folate levels. Most of the patients with severe PEM had normal cellularity with megaloblastic and dysplastic changes in bone marrow due to the inadequate and imbalanced intake of protein and energy.
- Pediatric hematology and oncology.Pediatr Hematol Oncol.2014 May;31(4):349-58. doi: 10.3109/08880018.2013.813098. Epub 2013 Aug 29.
- Background: All systems in an organism are affected by protein-energy malnutrition (PEM), but one of the worst affected is the hematopoietic system. Today PEM remains a very serious problem in developing countries. We examined the relationships between clinical features, hematological, and bone marr
- PMID 23987917
- Transcriptional Regulation of the Albumin Gene Depends on the Removal of Histone Methylation Marks by the Flavin-Adenine Dinucleotide-Dependent Monoamine Oxidase Lysine-Specific Demethylase 1 in HepG2 Human Hepatocarcinoma Cells.
- Liu D1, Zempleni J.Author information 1Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE.AbstractLysine-specific demethylase (LSD) 1 is an FAD-dependent demethylase that catalyzes the removal of methyl groups from lysine-4 in histone H3, thereby mediating gene repression. Here we tested the hypothesis that riboflavin deficiency causes a loss of LSD1 activity in HepG2 human hepatocarcinoma cells, leading to an accumulation of lysine-4-dimethylated histone H3 (H3K4me2) marks in the albumin promoter and aberrant upregulation of albumin expression. Cells were cultured in riboflavin-defined media providing riboflavin at concentrations representing moderately deficient (3.1 nmol/L), sufficient (12.6 nmol/L), and supplemented (301 nmol/L) cells in humans for 7 d. The efficacy of treatment was confirmed by assessing glutathione reductase activity and concentrations of reduced glutathione as markers of riboflavin status. LSD activity was 21% greater in riboflavin-supplemented cells compared with riboflavin-deficient and -sufficient cells. The loss of LSD activity was associated with a gain in the abundance of H3K4me2 marks in the albumin promoter; the abundance of H3K4me2 marks was ∼170% higher in riboflavin-deficient cells compared with sufficient and supplemented cells. The abundance of the repression mark, K9-trimethylated histone H3, was 38% lower in the albumin promoter of riboflavin-deficient cells compared with the other treatment groups. The expression of albumin mRNA was aberrantly increased by 200% in riboflavin-deficient cells compared with sufficient and supplemented cells. In conclusion, riboflavin deficiency impairs gene regulation by epigenetic mechanisms, mediated by a loss of LSD1 activity.
- The Journal of nutrition.J Nutr.2014 Apr 17. [Epub ahead of print]
- Lysine-specific demethylase (LSD) 1 is an FAD-dependent demethylase that catalyzes the removal of methyl groups from lysine-4 in histone H3, thereby mediating gene repression. Here we tested the hypothesis that riboflavin deficiency causes a loss of LSD1 activity in HepG2 human hepatocarcinoma cells
- PMID 24744315
- Carnitine in severely disabled patients: Relation to anthropometric, biochemical variables, and nutritional intake.
- Takeda Y1, Kubota M2, Sato H3, Nagai A3, Higashiyama Y3, Kin H1, Kawaguchi C1, Tomiwa K1.Author information 1Department of Pediatrics, Todaiji Medical and Education Center, Nara, Japan.2Faculty of Human Life and Environment, Nara Women's University, Nara, Japan. Electronic address: mkubota@cc.nara-wu.ac.jp.3Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.AbstractBackground: Carnitine plays a pivotal role in a variety of cellular functions. Carnitine deficiency often occurs in severely disabled patients, especially under valproic acid administration. However, the possible causative factors underlying carnitine deficiency have not been fully identified. The present study aimed at clarifying the association of various anthropometric and biochemical variables, including dietary intake of carnitine, with carnitine levels in severely disabled patients. Methods: Twenty-six severely disabled patients (mean age: 14.1years; s.d. 7.8) were enrolled. Plasma carnitine levels were evaluated by an enzyme cycling assay. Estimation of the dietary intake of carnitine was made based on dietary records over a 3-day period. Results: Plasma total and free carnitine levels in patients were significantly lower than those in controls obtained from the previous report. However, the ratios of free carnitine to total carnitine did not change significantly. Free carnitine levels were well correlated with a nutritional intake of carnitine. Administration of not only valproic acid but also other anti-epileptic drugs was found to cause a significant decrease of free carnitine levels after adjusting the nutritional intake of carnitine. Among various anthropometric or biochemical variables, albumin and uric acid showed a significant correlation with free carnitine levels. Conclusions: Physicians should be aware of the fact that severely disabled patients are at risk for carnitine deficiency even in the absence of valproic acid administration, and pay more attention to the nutritional intake of carnitine.
- Brain & development.Brain Dev.2014 Apr 16. pii: S0387-7604(14)00089-8. doi: 10.1016/j.braindev.2014.03.012. [Epub ahead of print]
- Background: Carnitine plays a pivotal role in a variety of cellular functions. Carnitine deficiency often occurs in severely disabled patients, especially under valproic acid administration. However, the possible causative factors underlying carnitine deficiency have not been fully identified. The p
- PMID 24746705
Japanese Journal
- Study of Serum Zinc and Copper Levels under Long-term Total Enteral Nutrition
- カルシウム非含有吸着ポリマーが惹起したと思われる血液透析患者の夜盲症2例
- 肝硬変における腹水濾過濃縮再静注法 : Cell-free and Concentrated Ascites Reinfusion Therapy, CART
Related Links
- Albumin deficiency Description, Causes and Risk Factors: Albumin is a kind of water soluble protein which is found in numerous forms in the natural world. It is an essential protein which is very important to maintain good health of ...
- NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free ... Question: What would be the possible causes of a albumen deficiency?
★リンクテーブル★
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- 英
- analbuminemia
- 同
- アルブミン欠乏症 albumin欠乏症 albumin deficiency、アルブミン欠乏血症 albumin deficiency disease
- 関
- アルブミン
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無アルブミン血症 : 約 9,520 件
アルブミン欠乏症 : 29 件
アルブミン欠乏血症 : 5 件
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- 不足、欠乏、欠失、欠如、欠損、不十分。栄養不足、栄養素欠乏、欠乏症。(遺伝子)(染色体内の)遺伝子欠失
- 欠けているもの、不足している物。不足分。不完全なもの、欠点のあるもの
- 関
- absence, agenesis, dearth, defect, defective, deficient, deficit, delete, deletion, deletional, depletion, deprivation, deprive, lack, miss, missing, morphological defect, paucity, scarce, scarcity, starve