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a crystalline amino acid that occurs in many proteins

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/10 05:08:46」(JST)

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Alanine aminopeptidase (EC 3.4.11.2) is an enzyme that is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is found at high levels in the urine when there are kidney problems.

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.^[3]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ "Entrez Gene: ANPEP alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)".

External links

The MEROPS online database for peptidases and their inhibitors: M01.001
CD13 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 肝移植：急性細胞性拒絶反応の診断 liver transplantation diagnosis of acute cellular rejection
2. 急性尿細管壊死の研究用バイオマーカーおよび評価 investigational biomarkers and the evaluation of acute tubular necrosis
3. 胆汁うっ滞系酵素の測定（アルカリホスファターゼ、5' -ヌクレオチダーゼ、γ-グルタミルトランスペプチダーゼなど） enzymatic measures of cholestasis eg alkaline phosphatase 5 nucleotidase gamma glutamyl transpeptidase
4. アルコール性肝炎：臨床症状および診断 alcoholic hepatitis clinical manifestations and diagnosis
5. 肝酵素および肝機能検査値の異常が認められた患者に対するアプローチ approach to the patient with abnormal liver biochemical and function tests

English Journal

Differential distribution and biochemical characteristics of hydrolases among developmental stages ofSchistosoma mansoni may offer new anti-parasite targets.

Fernández-Delgado M1, Cortez J1, Sulbarán G1, Matos C1, Incani RN2, Ballén DE1, Cesari IM1.
Parasitology international.Parasitol Int.2016 Sep 28. pii: S1383-5769(16)30170-2. doi: 10.1016/j.parint.2016.09.015. [Epub ahead of print]
Schistosoma mansoni enzymes play important roles in host-parasite interactions and are potential targets for immunological and/or pharmacological attack. The aim of this study was to comparatively assess the presence of hydrolytic activities (phosphatases, glycosidases, aminopeptidases) in soluble (
PMID 27693560

Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.

Węglarz-Tomczak E1, Burda-Grabowska M2, Giurg M3, Mucha A4.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2016 Sep 20. pii: S0960-894X(16)30990-8. doi: 10.1016/j.bmcl.2016.09.050. [Epub ahead of print]
A collection of twenty-six organoselenium compounds, ebselen and its structural analogues, provided a novel approach for inhibiting the activity of human methionine aminopeptidase 2 (MetAP2). This metalloprotease, being responsible for the removal of the amino-terminal methionine from newly synthesi
PMID 27692546

Isolation of autologous adipose tissue-derived mesenchymal stem cells for bone repair.

Raposio E1, Bonomini S2, Calderazzi F3.
Orthopaedics & traumatology, surgery & research : OTSR.Orthop Traumatol Surg Res.2016 Sep 13. pii: S1877-0568(16)30100-1. doi: 10.1016/j.otsr.2016.07.006. [Epub ahead of print]
INTRODUCTION: Adipose tissue represents an abundant and accessible source of adult stem cells that can differentiate into cells and tissues of mesodermal origin, including osteogenic cells.METHODS: This paper describes the procedure to obtain a 5-cm3 saline sample, containing the adipose-derived ste
PMID 27638160

Japanese Journal

ペプチドからグリシンとD-アラニンを遊離する新規な麹菌アミノペプチダーゼ

日本醸造協会誌 = Journal of the Brewing Society of Japan 108(2), 68-75, 2013-02-15
NAID 10031156339

尿検査尿中アラニンアミノペプチダーゼ (広範囲血液・尿化学検査,免疫学的検査(第7版・1)その数値をどう読むか) -- (一般検査(尿・髄液・糞便検査を含む))

日本臨床 67(-), 158-160, 2009-12
NAID 40016874454

HP-188-1 成人間生体部分肝移植後における胆汁中Alanine aminopeptidase (AAP)の意義(移植医療1,ハイブリッドポスター,第109回日本外科学会定期学術集会)

日本外科学会雑誌 110(臨時増刊号_2), 708, 2009-02-25
NAID 110007166567

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リンク元	「アラニンアミノペプチダーゼ」
拡張検索	「alanine-aminopeptidase」
関連記事	「alanine」「aminopeptidase」

「アラニンアミノペプチダーゼ」

ANPEP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4FYQ, 4FYR, 4FYS, 4FYT
Identifiers
Aliases	ANPEP, APN, CD13, GP150, LAP1, P150, PEPN, alanyl aminopeptidase, membrane
External IDs	OMIM: 151530 MGI: 5000466 HomoloGene: 68163 GeneCards: 290
Gene ontology
Molecular function	• virus receptor activity; • zinc ion binding; • receptor activity; • metalloaminopeptidase activity; • hydrolase activity; • metal ion binding; • peptide binding; • peptidase activity; • aminopeptidase activity; • metallopeptidase activity;
Cellular component	• vesicle lumen; • integral component of plasma membrane; • lysosomal membrane; • extracellular space; • cytoplasm; • vesicle membrane; • integral component of membrane; • membrane; • cytosol; • endoplasmic reticulum-Golgi intermediate compartment; • external side of plasma membrane; • extracellular exosome; • plasma membrane;
Biological process	• negative regulation of renal sodium excretion; • viral process; • peptide catabolic process; • proteolysis; • viral entry into host cell; • multicellular organism development; • cell differentiation; • angiogenesis; • cellular aromatic compound metabolic process;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	290
	16790
	ENSG00000166825
	ENSMUSG00000039062
	P15144
	P97449
	NM_001150
	NM_008486
	NP_001141.2
	NP_032512.2
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: alanine aminopeptidase, AAP
関: N-acetyl-beta-glucosaminidase NAG

尿細管障害のマーカー
尿細管上皮細胞由来の逸脱酵素

「alanine-aminopeptidase」

　　[★] アラニンアミノペプチダーゼ

「alanine」

　　[★]

アラニン

関: A、Ala、alanyl、L-alanine

「aminopeptidase」

　　[★]

アミノペプチダーゼ

[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[entrez-3] "Entrez Gene: ANPEP alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)".

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v t e Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

匿名

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案内

案内

alanine aminopeptidase