WordNet

any mature animal
a fully developed person from maturity onward (同)grownup
(of animals) fully developed; "an adult animal"; "a grown woman" (同)big, full-grown, fully grown, grown, grownup

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1. 異染性白質ジストロフィー metachromatic leukodystrophy
2. 全身疾患と関連した遺伝性ニューロパチー hereditary neuropathies associated with generalized disorders
3. アスパルトアシラーゼ欠乏症（カナバン病） aspartoacylase deficiency canavan disease
4. アレキサンダー病 alexander disease
5. 遺伝性痙性対麻痺 hereditary spastic paraplegia

Distribution of C16:0, C18:0, C24:1 and C24:0 sulfatides in CNS lipid rafts by quantitative UHPLC-MS/MS.

Moyano AL1, Li G2, Lopez-Rosas A1, Månsson JE3, van Breemen RB2, Givogri MI4.
Analytical biochemistry.Anal Biochem.2014 Sep 6. pii: S0003-2697(14)00388-1. doi: 10.1016/j.ab.2014.08.033. [Epub ahead of print]
Sulfated galactosylceramides (sulfatides) are glycosphingolipids associated with cholesterol- and sphingolipid-enriched membrane microdomains (lipid rafts) and are highly expressed in brain tissue. While it is known that sulfatide species show heterogeneity in their fatty acid acyl group composition
PMID 25205652

Lentivector integration sites in ependymal cells from a model of metachromatic leukodystrophy: non-B DNA as a new factor influencing integration.

McAllister RG1, Liu J2, Woods MW1, Tom SK1, Rupar CA3, Barr SD1.
Molecular therapy. Nucleic acids.Mol Ther Nucleic Acids.2014 Aug 26;3:e187. doi: 10.1038/mtna.2014.39.
The blood-brain barrier controls the passage of molecules from the blood into the central nervous system (CNS) and is a major challenge for treatment of neurological diseases. Metachromatic leukodystrophy is a neurodegenerative lysosomal storage disease caused by loss of arylsulfatase A (ARSA) activ
PMID 25158091

Comparative Efficacy and Safety of Multiple Routes of Direct CNS Administration of Adeno-Associated Virus Gene Transfer Vector Serotype rh.10 Expressing the Human Arylsulfatase A cDNA to Nonhuman Primates.

Rosenberg JB1, Sondhi D, Rubin DG, Monette S, Chen A, Cram S, De BP, Kaminsky SM, Sevin C, Aubourg P, Crystal RG.
Human gene therapy. Clinical development.Hum Gene Ther Clin Dev.2014 Aug 21. [Epub ahead of print]
Abstract Metachromatic leukodystrophy (MLD), a fatal disorder caused by deficiency of the lysosomal enzyme arylsulfatase A (ARSA), is associated with an accumulation of sulfatides, causing widespread demyelination in both central and peripheral nervous systems. On the basis of prior studies demonstr
PMID 25144894