アディポサイトカイン
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/08 23:31:48」(JST)
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The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue. The first adipokine to be discovered was leptin in 1994.[1] Since that time hundreds of adipokines have been discovered.[2]
Members include:
- Leptin
- Adiponectin
- Apelin[3]
- chemerin[4]
- interleukin-6 (IL-6)[5]
- monocyte chemotactic protein-1 (MCP-1)[6]
- plasminogen activator inhibitor-1 (PAI-1)
- retinol binding protein 4 (RBP4)
- tumor necrosis factor-alpha (TNFα)
- visfatin
In addition, interleukin 8 (IL-8), interleukin 10 (IL-10), interferon gamma (IFN-γ) and inducible protein 10 (IP-10 or CXCL10) have been shown to be associated with excessive body weight.[7]
Classification
As of 2008, the current terminology refers to a cytokine as an immunomodulating agent. However, conflicting data exists about what is termed a cytokine and what is termed a hormone and more research is needed in this area of defining cytokines and hormones. Under the current terminology, adiponectin, leptin (Ob ligand), and resistin are not appropriately considered adipokines (cytokines) as they do not act on the immune system. (Harrison's Principles of Internal Medicine). Often, these peptides (adiponectin, leptin, and resistin) are referred to as adipokines, however they can be more accurately put into the larger, growing list of adipose-derived hormones.
Notes
- ^ Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BIOFACTORS 37 (6): 413–420. doi:10.1002/biof.185. PMID 22038756.
- ^ Lehr S, Hartwig S, Sell H (2012). "Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders". PROTEOMICS. CLINICAL APPLICATIONS. 6 (1-2): 91–101. doi:10.1002/prca.201100052. PMID 22213627.
- ^ Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009;34(4):142-54.
- ^ MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159-161
- ^ Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048-1054
- ^ Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150
- ^ Sharabiani, MT; Vermeulen R, Scoccianti C, Hosnijeh FS, Minelli L, Sacerdote C, Palli D, Krogh V, Tumino R, Chiodini P, Panico S, Vineis P. (May 2011). "Immunologic profile of excessive body weight". Biomarkers 16 (3): 243–51. doi:10.3109/1354750X.2010.547948. PMID 21506696.
External links
- Adipokines at the US National Library of Medicine Medical Subject Headings (MeSH)
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Intercellular signaling peptides and proteins / ligands
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| Growth factors |
- Endothelial growth factor
- Epidermal growth factor
- Fibroblast growth factor
- Nerve growth factor
- Platelet-derived growth factor
- Transforming growth factor beta superfamily
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| Ephrin |
- EFNA1
- EFNA2
- EFNA3
- EFNA4
- EFNA5
- EFNB1
- EFNB2
- EFNB3
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| Other |
- Adipokine
- Agouti signaling protein
- Agouti-related protein
- Angiogenic protein
- CCN intercellular signaling protein
- Cysteine-rich protein 61
- Connective tissue growth factor
- Nephroblastoma overexpressed protein
- Cytokine
- Endothelin
- Hedgehog protein
- Interferon
- Kinin
- Parathyroid hormone-related protein
- Semaphorin
- Somatomedin
- Tolloid-like metalloproteinase
- Tumor necrosis factor
- Wnt protein
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see also extracellular ligand disorders
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Index of signal transduction
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| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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English Journal
- Visceral adipose tissue-derived serine protease inhibitor augments acetylcholine-induced relaxation via the inhibition of acetylcholine esterase activity in rat isolated mesenteric artery.
- Kameshima S1, Yamada K1, Morita T1, Okada M1, Yamawaki H1.
- Acta physiologica (Oxford, England).Acta Physiol (Oxf).2016 Feb;216(2):203-10. doi: 10.1111/apha.12563. Epub 2015 Aug 31.
- AIM: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing activity originally identified in visceral adipose tissues of obesity-related type II diabetic rats. We previously showed that vaspin inhibits vascular cell migration and apoptosis as
- PMID 26264600
- Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines.
- Pavan Kumar N1, Nair D2, Banurekha VV2, Dolla C2, Kumaran P2, Sridhar R3, Babu S4.
- Cytokine.Cytokine.2016 Jan 6;79:74-81. doi: 10.1016/j.cyto.2015.12.026. [Epub ahead of print]
- Type 2 diabetes mellitus (T2DM) is recognized as major risk factor for the progress of active pulmonary tuberculosis (PTB), although the mechanistic link between diabetes and tuberculosis remains poorly characterized. Moreover, the influence of poorly controlled diabetes on the baseline levels of ad
- PMID 26771473
- Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy.
- Zhou B1, Feng B1, Qin Z2, Zhao Y3, Chen Y1, Shi Z1, Gong Y1, Zhang J1, Yuan F4, Mu J5.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Jan 5;419:72-82. doi: 10.1016/j.mce.2015.10.001. Epub 2015 Oct 9.
- Visfatin, a recently discovered adipocytokine, has been shown to have an important role in the pathogenesis of diabetic nephropathy (DN). The farnesoid X receptor (FXR), a ligand-activated nuclear receptor, plays a protective role in DN. The regulation between FXR and visfatin and their interaction
- PMID 26450152
Japanese Journal
- Adipolinによるインスリン抵抗性改善作用 (特集 インスリン感受性,エネルギー代謝の新規モディファイヤー)
- 2) 妊娠高血圧症候群における炎症とアディポサイトカイン : 着床機構と病態発現への関与(シンポジウム2:周産期「妊娠高血圧症候群の基礎と臨床-予防・治療の新戦略に向けて」,第65回日本産科婦人科学会・学術講演会)
- 成瀬 勝彦
- 日本産科婦人科學會雜誌 65(11), 2583-2590, 2013-11-01
- Recently, the pathophysiological mechanism of pregnancy-induced hypertension (PIH) has been gradually revealed. The latest key thesis being the so-called 2-step theory, which suggests that the cause o …
- NAID 110009674982
- 2) 妊娠高血圧症候群における炎症とアディポサイトカイン : 着床機構と病態発現への関与(シンポジウム2:周産期「妊娠高血圧症候群の基礎と臨床-予防・治療の新戦略に向けて」,第65回日本産科婦人科学会・学術講演会)
- 成瀬 勝彦
- 日本産科婦人科學會雜誌 65(11), 2583-2590, 2013-11-01
- Recently, the pathophysiological mechanism of pregnancy-induced hypertension (PIH) has been gradually revealed. The latest key thesis being the so-called 2-step theory, which suggests that the cause o …
- NAID 110009661870
Related Links
- Adipokine. From Wikipedia, the free encyclopedia. Jump to: navigation, search. The adipokines or adipocytokines (Greek adipo-, fat; cyto-, cell; and -kinos, movement) are cytokines (cell-to-cell signaling proteins) secreted by adipose tissue.
- Adipocytokine signaling pathway - Homo sapiens (human), Help. [ Pathway menu | Organism menu | Pathway entry | Download KGML | Show description | User data mapping ]. Increased adipocyte volume and number are positively ...
Related Pictures
★リンクテーブル★
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- 英
- adipokine
- 同
- アディポサイトカイン adipocytokine
- 関
- 内臓脂肪型肥満
- 脂肪細胞が分泌する細胞増殖制御因子の総称
- 脂肪組織から分泌されるレプチン、TNF-αなどで、食欲や脂質代謝の調節に関わる。
- 脂肪細胞が分泌するサイトカイン
- 肥満によりインスリン抵抗性を付与するアディポカインの産生が増加
- 遊離脂肪酸：インスリン抵抗性上昇
- レジスチン：インスリン抵抗性上昇
- TNF-α：インスリン抵抗性上昇
- IL-6：インスリン抵抗性上昇
- angiotensinogen
- PAI-1：
- アディポネクチン：インスリン感受性、代謝性疾患の改善
- レプチン：食欲抑制、インスリン感受性の改善
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アディポサイトカイン