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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/15 15:08:07」(JST)

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Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a socially troubling but benign condition, hypohidrosis can lead to hyperthermia, heat exhaustion, heat stroke and potentially death.^[1] An extreme case of hypohydrosis in which there is a complete absence of sweating and the skin is dry is termed anhidrosis.

Causes

Medications

Anticholinergic agents
Opioids
Botulinum toxin
Alpha-2 receptor antagonists
Clonidine
Barbiturates
Zonisamide

Physical agents

Tumors
Burns
Radiation
Surgery
Scars
Sores

Dermatological

X-linked hypohidrotic ectodermal dysplasia
Incontinentia pigmenti
Bazex disease
Fabry disease
Miliaria
Sjogren syndrome
Systemic sclerosis
Graft-versus-host disease

Neuropathic

Multiple system atrophy
Dementia with Lewy bodies
Multiple sclerosis
Cerebrovascular accident
Tumour
Encephalitis
Cervical myelopathy
Diabetes mellitus
Guillain–Barré syndrome
Hereditary sensory and autonomic neuropathy
Alcoholism
Amyloidosis
Ross syndrome
Pure autonomic failure
Horner's syndrome

Diagnosis

Sweat is readily visualized by a topical indicator such as iodinated starch (Minor test) or sodium alizarin sulphonate, both of which undergo a dramatic colour change when moistened by sweat. A thermoregulatory sweat test can evaluate the body’s response to a thermal stimulus by inducing sweating through a hot box ⁄ room, thermal blanket or exercise. Failure of the topical indicator to undergo a colour change during thermoregulatory sweat testing indicates hypohidrosis, and further tests may be required to localize the lesion.

Magnetic resonance imaging of the brain and ⁄ or spinal cord is the best modality for evaluation when the lesion is suspected to be localized to the central nervous system.

Skin biopsies are useful when anhidrosis occurs as part of a dermatological disorder. Biopsy results may reveal the sweat gland destruction, necrosis or fibrosis, in addition to the findings of the primary dermatological disorder.

Management

The treatment options for hypohidrosis and anhidrosis is limited. Those with hypohidrosis should avoid drugs that can aggravate the condition (see medication-causes). They should limit activities that raise the core body temperature and if exercises are to be performed, they should be supervised and be performed in a cool, sheltered and well-ventilated environment. In instances where the cause is known, treatment should be directed at the primary pathology. In autoimmune diseases, such as Sjogren syndrome and systemic sclerosis, treatment of the underlying disease using immunosuppressive drugs may lead to improvement in hypohidrosis. In neurological diseases, the primary pathology is often irreversible. In these instances, prevention of further neurological damage, such as good glycaemic control in diabetes, is the cornerstone of management. In acquired generalized anhidrosis, spontaneous remission may be observed in some cases. Numerous cases have been reported to respond effectively to systemic corticosteroids. Although an optimum dose and regime has not been established, pulse methylprednisolone (up to 1000 mg ⁄ day) has been reported to have good effect.^{[citation needed]}

References

^ Chia, K. Y.; Tey, H. L. (2012). "Approach to hypohidrosis". Journal of the European Academy of Dermatology and Venereology. 27 (7): 799–804. PMID 23094789. doi:10.1111/jdv.12014.

Notes

http://www.mayoclinic.com/health/anhidrosis/DS01050^{[full citation needed]}
MedlinePlus Encyclopedia Sweating - absent

English Journal

Transcriptomic analysis of FUCA1 knockdown in keratinocytes reveals new insights in the pathogenesis of fucosidosis skin lesions.

Valero-Rubio D1, Jiménez KM1, Fonseca DJ1, Payán-Gomez C2, Laissue P1.
Experimental dermatology.Exp Dermatol.2018 Mar 8. doi: 10.1111/exd.13532. [Epub ahead of print]
PMID 29518279

A Probable Topiramate-induced Limbs Paraesthesia and Rigid Fingers Flexion

Pratico AD1, Ruggieri M1, Falsaperla R2, Pavone P2.
Current drug safety.Curr Drug Saf.2018 Feb 12. doi: 10.2174/1574886313666180213090445. [Epub ahead of print]
PMID 29437013

Long-Term Health Effects of PCBs and Related Compounds: A Comparative Analysis of Patients Suffering from Yusho and the General Population.

Akahane M1, Matsumoto S2, Kanagawa Y2, Mitoma C3, Uchi H4, Yoshimura T5, Furue M4, Imamura T2.
Archives of environmental contamination and toxicology.Arch Environ Contam Toxicol.2018 Feb;74(2):203-217. doi: 10.1007/s00244-017-0486-6. Epub 2017 Dec 18.
PMID 29256109

Japanese Journal

自己免疫疾患の関与が示唆された後天性全身性無汗症の１症例

日本内科学会雑誌 80(10), 1680-1681, 1991
NAID 130000900375

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