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Neuropeptide Y receptor mediates activation of ERK1/2 via transactivation of the IGF receptor.

Lecat S1, Belemnaba L2, Galzi JL3, Bucher B2.
Cellular signalling.Cell Signal.2015 Jul;27(7):1297-304. doi: 10.1016/j.cellsig.2015.03.016. Epub 2015 Mar 25.
Neuropeptide Y binds to G-protein coupled receptors whose action results in inhibition of adenylyl cyclase activity. Using HEK293 cells stably expressing the native neuropeptide Y Y1 receptors, we found that the NPY agonist elicits a transient phosphorylation of the extracellular signal-regulated ki
PMID 25817573

Coordinated Induction of GST and MRP2 by cAMP in Caco-2 Cells. Role of protein kinase A signaling pathway and toxicological relevance.

Arana MR1, Tocchetti GN2, Domizi P3, Arias A4, Rigalli JP5, Ruiz ML6, Luquita MG7, Banchio C8, Mottino AD9, Villanueva SS10.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2015 Jun 3. pii: S0041-008X(15)30011-9. doi: 10.1016/j.taap.2015.06.003. [Epub ahead of print]
The cAMP pathway is a universal signaling regulating many cellular processes including metabolic routes, growth and differentiation, whereas its effects on xenobotic biotransformation and transport systems are poorly characterized. The effect of cAMP on expression and activity of GST and MRP2 was ev
PMID 26049102

Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.

Gimenez LE1, Baameur F1, Vayttaden SJ1, Clark RB2.
Molecular pharmacology.Mol Pharmacol.2015 Jun;87(6):954-64. doi: 10.1124/mol.114.096800. Epub 2015 Mar 17.
Salmeterol is a long-acting β2-adrenergic receptor (β2AR) agonist that is widely used as a bronchodilator for the treatment of persistent asthma and chronic obstructive pulmonary disease in conjunction with steroids. Previous studies demonstrated that salmeterol showed weak efficacy for activation
PMID 25784721

Nishio Aiko,Kitamura Naoki,Tanaka Saki,Miyazaki Shunsuke,Ichiyanagi Tsuyoshi,Shimomura Norihiro,Shibuya Izumi,Aimi Tadanori
Biological and Pharmaceutical Bulletin 35(8), 1300-1305, 2012
… Moreover, the adenylyl cyclase inhibitor, SQ-22536, significantly inhibited the relaxing effect of gymnopilins at 1 mg/mL on the norepinephrine-contracted strips. …
NAID 130001872142

Regulation of Monocarboxylate Transporter 1 in Skeletal Muscle Cells by Intracellular Signaling Pathways

Narumi Katsuya,Furugen Ayako,Kobayashi Masaki,Otake Sho,Itagaki Shirou,Iseki Ken
Biological and Pharmaceutical Bulletin 33(9), 1568-1573, 2010
… The uptake of L-lactic acid via MCT1 was studied in the presence of various intracellular regulatory pathways, including pathways mediated by protein kinases A, C and G (PKA, PKC and PKG), protein tyrosine kinase (PTK), and Ca2+/calmodulin modulators. … On the other hand, exposure to 8-Br-cAMP, a cAMP analog, and to forskolin, an adenylyl cyclase activator, resulted in a significant decrease in L-lactic acid uptake. …
NAID 130000322358

Stimulation of the cAMP system by the nitric oxide-cGMP system underlying the formation of long-term memory in an insect

Matsumoto Yukihisa,Hatano Ai,Unoki Sae,Mizunami Makoto
Neuroscience Letters 467(2), 81-85, 2009-12-25
… In honey bees, the two systems have been suggested to converge on protein kinase A (PKA), based on the finding in vitro that cGMP activates PKA when sub-optimal dose of cAMP is present. … In crickets, however, we have suggested that NO-cGMP pathway operates on PKA via activation of adenylyl cyclase and production of cAMP for LTM formation. …
NAID 120001702451