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1. Chapter 6A：ホルモンの作用機序 chapter 6a mechanisms of hormone action
2. 心不全および心筋梗塞における遺伝子療法および細胞療法 genetic and cellular therapy in heart failure and myocardial infarction
3. 甲状腺結節および非髄様甲状腺癌におけるオンコジーンおよび腫瘍抑制遺伝子 oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer
4. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
5. 心筋における興奮収縮連関 excitation contraction coupling in myocardium

English Journal

SILAC-Based Strategy for Proteome-Wide Thermodynamic Analysis of Protein-Ligand Binding Interactions.

Tran DT1, Adhikari J, Fitzgerald MC.
Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2014 Apr 16. [Epub ahead of print]
Described here is a quantitative mass spectrometry-based proteomics method for the large-scale thermodynamic analysis of protein-ligand binding interactions. The methodology utilizes a chemical modification strategy termed, Stability of Proteins from Rates of Oxidation (SPROX), in combination with a
PMID 24741112

Crystal structures of d-alanine-d-alanine ligase from Xanthomonas oryzae pv. oryzae alone and in complex with nucleotides.

Doan TT1, Kim JK1, Ngo HP2, Tran HT2, Cha SS3, Min Chung K4, Huynh KH2, Ahn YJ5, Kang LW6.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2014 Mar 1;545:92-9. doi: 10.1016/j.abb.2014.01.009. Epub 2014 Jan 16.
D-Alanine-D-alanine ligase (DDL) catalyzes the biosynthesis of d-alanyl-d-alanine, an essential bacterial peptidoglycan precursor, and is an important drug target for the development of antibacterials. We determined four different crystal structures of DDL from Xanthomonas oryzae pv. oryzae (Xoo) ca
PMID 24440607

Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.

Huang H1, Zeqiraj E2, Dong B3, Jha BK3, Duffy NM4, Orlicky S4, Thevakumaran N2, Talukdar M1, Pillon MC5, Ceccarelli DF4, Wan LC1, Juang YC4, Mao DY6, Gaughan C3, Brinton MA7, Perelygin AA7, Kourinov I8, Guarné A5, Silverman RH9, Sicheri F10.
Molecular cell.Mol Cell.2014 Jan 23;53(2):221-34. doi: 10.1016/j.molcel.2013.12.025.
RNase L is an ankyrin repeat domain-containing dual endoribonuclease-pseudokinase that is activated by unusual 2,'5'-oligoadenylate (2-5A) second messengers and which impedes viral infections in higher vertebrates. Despite its importance in interferon-regulated antiviral innate immunity, relatively
PMID 24462203

,
The Journal of Biochemistry 111(6), 804-809, 1992
… A similar difference in the dissociation constants of myosin for F-actin was observed in the presence of adenylyl imidodiphosphate. …
NAID 130003417441

Interaction of F-actin-AMPPNP with myosin subfragment-1 and troponin-tropomyosin: Influence of an extra phosphate at the nucleotide binding site in F-actin on its function.

Energy-independent protection of the oxidative phosphorylation capacity of mitochondria against anoxic damage by ATP and its non-metabolizable analogs.

, ,
The Journal of Biochemistry 97(4), 1229-1234, 1985
… The capacity was well preserved in the presence of ATP and did not require the hydrolysis of ATP, since ATP analogs, such as β, γ-methylene adenosine triphosphate (AMPPCP), α, β-methylene adenosine triphosphate (AMPCPP), and adenylyl imidodiphosphate (AMPPNP), were as effective as ATP. …
NAID 130003543279