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1. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
2. 胃酸分泌の生理学 physiology of gastric acid secretion
3. 気道の神経制御 neuronal control of the airways
4. 百日咳菌感染症の微生物学、疫学、および病因 microbiology epidemiology and pathogenesis of bordetella pertussis infection
5. 筋肉におけるエネルギー代謝 energy metabolism in muscle

English Journal

Wu J1, Bond C1, Chen P1, Chen M1, Li Y1, Shohet RV2, Wright G3.
Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2015 May;82:194-200. doi: 10.1016/j.yjmcc.2015.01.014. Epub 2015 Feb 11.
These studies have examined the effect of hypoxia inducible factor 1α (HIF-1α) on nucleotide metabolism in the ischemic heart using a genetic mouse model with heart-specific and regulated expression of a stable form of HIF-1α. We find that AMP deaminase (AMPD), the entry point of the purine nucle
PMID 25681585

The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

Boutchueng-Djidjou M1, Collard-Simard G1, Fortier S1, Hébert SS2, Kelly I3, Landry CR4, Faure RL5.
Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2015 Apr;14(4):1079-92. doi: 10.1074/mcp.M114.047159. Epub 2015 Feb 16.
Insulin is internalized with its cognate receptor into the endosomal apparatus rapidly after binding to hepatocytes. We performed a bioinformatic screen of Golgi/endosome hepatic protein fractions and found that ATIC, which is a rate-limiting enzyme in the de novo purine biosynthesis pathway, and PT
PMID 25687571

AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.

Tandelilin AA1,2, Hirase T3, Hudoyo AW4,5, Cheng J6,7, Toyama K8,9, Morisaki H10,11, Morisaki T12,13.
BMC endocrine disorders.BMC Endocr Disord.2015 Mar 27;15:11. doi: 10.1186/s12902-015-0010-9.
BACKGROUND: Insulin resistance triggered by excess fat is a key pathogenic factor that promotes type 2 diabetes. Understanding molecular mechanisms of insulin resistance may lead to the identification of a novel therapeutic target for type 2 diabetes. AMPD1, an isoform of AMP deaminase (AMPD), is su
PMID 25887856