WordNet
- (biochemistry) purine base found in DNA and RNA; pairs with thymine in DNA and with uracil in RNA (同)A
- a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) (同)base
PrepTutorEJDIC
- アデニン(肝臓・茶の葉から採れる塩基の一種)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/03 18:00:14」(JST)
[Wiki en表示]
| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
| Identifiers |
| Symbol |
SLC25A4 |
| Alt. symbols |
PEO3, PEO2, ANT1 |
| Entrez |
291 |
| HUGO |
10990 |
| OMIM |
103220 |
| RefSeq |
NM_001151 |
| UniProt |
P12235 |
| Other data |
| Locus |
Chr. 4 q35 |
| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 |
| Identifiers |
| Symbol |
SLC25A5 |
| Alt. symbols |
ANT2 |
| Entrez |
292 |
| HUGO |
10991 |
| OMIM |
300150 |
| RefSeq |
NM_001152 |
| UniProt |
P05141 |
| Other data |
| Locus |
Chr. X q24-q26 |
| solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
| Identifiers |
| Symbol |
SLC25A6 |
| Alt. symbols |
ANT3 |
| Entrez |
293 |
| HUGO |
10992 |
| OMIM |
403000 |
| RefSeq |
NM_001636 |
| UniProt |
P12236 |
| Other data |
| Locus |
Chr. Y p |
Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and imports ADP into the matrix.[1] ANT is the most plentiful protein in the inner mitochondrial membrane.[1]
Contents
- 1 Function
- 2 Types
- 3 See also
- 4 Footnotes
- 5 External links
Function
ANT has long been thought to function asymmetrically as a homodimer of subunits in the inner mitochondrial membrane. The dimer was thought to be a gated pore through which ADP and ATP were exchanged between the mitochondrial matrix and the cytoplasm. The dimer hypothesis was first challenged when the three-dimensional structure of ANT was discovered to be a monomer.[2] Further work has shown that ANT functions as a monomer in detergents[3] and in mitochondrial membranes.[4][5]
ANT is an important structural component of the mitochondrial permeability transition pore[1][irrelevant citation] which can open and lead to cell death through apoptosis or necrosis.
Types
In humans, there exist three paraologous ANT isoforms:
- SLC25A4 – found primarily in heart and skeletal muscle
- SLC25A5 – primarily expressed in fibroblasts
- SLC25A6 – primarily express in liver
See also
- ^ a b c Kaukonen J, Juselius JK, Tiranti V, Kyttälä A, Zeviani M, Comi GP, Keränen S, Peltonen L, Suomalainen A (2000). "Role of adenine nucleotide translocator 1 in mtDNA maintenance". Science. 289 (5480): 782–785. doi:10.1126/science.289.5480.782. PMID 10926541.
- ^ Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trézéguet V, Lauquin GJ, Brandolin G (November 2003). "Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside". Nature. 426 (6962): 39–44. doi:10.1038/nature02056. PMID 14603310.
- ^ Bamber L, Slotboom DJ, Kunji ER (August 2007). "Yeast mitochondrial ADP/ATP carriers are monomeric in detergents as demonstrated by differential affinity purification". J. Mol. Biol. 371 (2): 388–95. doi:10.1016/j.jmb.2007.05.072. PMID 17572439.
- ^ Bamber L, Harding M, Monné M, Slotboom DJ, Kunji ER (June 2007). "The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes". Proc. Natl. Acad. Sci. U.S.A. 104 (26): 10830–4. doi:10.1073/pnas.0703969104. PMC 1891095. PMID 17566106.
- ^ Kunji ER, Crichton PG (March 2010). "Mitochondrial carriers function as monomers". Biochim Biophys Acta. 1797 (6–7): 817–831. doi:10.1016/j.bbabio.2010.03.023. PMID 20362544.
External links
- Adenine Nucleotide Translocator 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Adenine Nucleotide Translocator 2 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Adenine Nucleotide Translocator 3 at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
|
|
|
|
|
|
Ion pumps
|
|
| Symporter, Cotransporter |
- Na+/K+,Cl−
- Na+/Pi3
- Na+/Cl−
- Na+/glucose
- Na+/I−
- Cl−/K+
|
|
| Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
- Cl−-formate
- Cl−-oxalate
|
|
|
|
|
see also solute carrier disorders
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 分子遺伝学の原理principles of molecular genetics [show details]
… thymine is the pyrimidine complementary to adenine, but uracil replaces thymine in RNA.… with an estimated error rate of 10(-9) to 10(-11) per incorporated nucleotide in eukaryotes.…
- 2. 遺伝学：用語集genetics glossary of terms [show details]
… with central nucleotide side chains The two strands are held together by hydrogen bonds that link each purine to a pyrimidine (between adenine and thymine and between guanine and cytosine). The energy …
- 3. 遺伝学およびゲノミクスのためのツール：ポリメラーゼ連鎖反応tools for genetics and genomics polymerase chain reaction [show details]
… The error rate (per nucleotide per cycle) for standard Taq is about 1 in 105 nucleotides.… small number of nucleic acid sequences from the patient (on average, 1). PCR is then performed in each packet, resulting in a binary result in which the target nucleic acid of interest…
- 4. 血液製剤の病原体不活化pathogen inactivation of blood products [show details]
… platelets. A portion of the riboflavin (vitamin B2) molecule binds to nucleic acids and UV light activation can oxidize the guanine nucleotide (G) . In this case the UV is mostly UVB but also uses light in the …
- 5. 脂質およびプリン代謝障害による代謝性ミオパチーmetabolic myopathies caused by disorders of lipid and purine metabolism [show details]
…inosine monophosphate and ammonia. MADA deficiency results in decreased entry of adenine nucleotides into the purine nucleotide cycle during exercise . This enzyme has three tissue-specific subunits: E (erythrocyte) …
English Journal
- Utilizing Gold Nanoparticle Probes to Visually Detect DNA Methylation.
- Chen K1,2, Zhang M1, Chang YN1, Xia L1, Gu W1, Qin Y1, Li J1, Cui S3, Xing G4.
- Nanoscale research letters.Nanoscale Res Lett.2016 Dec;11(1):304. doi: 10.1186/s11671-016-1487-5. Epub 2016 Jun 21.
- The surface plasmon resonance (SPR) effect endows gold nanoparticles (GNPs) with the ability to visualize biomolecules. In the present study, we designed and constructed a GNP probe to allow the semi-quantitative analysis of methylated tumor suppressor genes in cultured cells. To construct the probe
- PMID 27325520
- An impaired metabolism of nucleotides underpins a novel mechanism of cardiac remodeling leading to Huntington's disease related cardiomyopathy.
- Toczek M1, Zielonka D2, Zukowska P1, Marcinkowski JT2, Slominska E1, Isalan M3, Smolenski RT4, Mielcarek M5.
- Biochimica et biophysica acta.Biochim Biophys Acta.2016 Nov;1862(11):2147-2157. doi: 10.1016/j.bbadis.2016.08.019. Epub 2016 Aug 26.
- Huntington's disease (HD) is mainly thought of as a neurological disease, but multiple epidemiological studies have demonstrated a number of cardiovascular events leading to heart failure in HD patients. Our recent studies showed an increased risk of heart contractile dysfunction and dilated cardiom
- PMID 27568644
- Time- and anion-dependent stimulation on triphosphopyridine nucleotide followed by antioxidant responses in Vibrio fischeri after exposure to 1-ethyl-3-methylimidazolium salts.
- Yu Z1, Mo L2, Zhang J3, Liu S1.
- Chemosphere.Chemosphere.2016 Nov;163:452-60. doi: 10.1016/j.chemosphere.2016.08.061. Epub 2016 Aug 24.
- A toxicity database of over 157 ionic liquids (ILs) was established on Vibrio fischeri (VF). The database contained mainly monotonic concentration-response relationship, and its application in risk assessment was challenged by potential non-monotonic hormetic effects of ILs. In the present study, th
- PMID 27565313
Japanese Journal
- 細胞外アデニンヌクレオチド分解活性は亜鉛栄養状態を反映する (第41回日本栄養アセスメント研究会 発表演題より(推薦論文))
- 武田 貴成,笹川 剛,駒井 三千夫,神戸 大朋
- 栄養 = Trends of nutrition 4(1), 47-49, 2019-03
- NAID 40021909672
- GC/MS and LC/MS-based Tissue Metabolomic Analysis Detected Increased Levels of Antioxidant Metabolites in Colorectal Cancer
- Kibi Megumi,Nishiumi Shin,Kobayashi Takashi,Kodama Yuzo,Yoshida Masaru
- The Kobe journal of the medical sciences 65(1), 19-27, 2019
- … Regarding nucleotide metabolomic intermediates, the colorectal cancer tissue contained lower levels of ribulose 5-phosphate and higher levels of xanthine, adenine, and hypoxanthine than the normal tissue. …
- NAID 120006644115
- Functional characterization of the partially purified Sac1p independent adenine nucleotide transport system (ANTS) from yeast endoplasmic reticulum
- Li Yuan,Cappello Anna Rita,Muto Luigina,Martello Emanuela,Madeo Marianna,Curcio Rosita,Lunetti Paola,Raho Susanna,Zaffino Francesco,Frattaruolo Luca,Lappano Rosamaria,Malivindi Rocco,Maggiolini Marcello,Aiello Donatella,Piazzolla Carmela,Capobianco Loredana,Fiermonte Giuseppe,Dolce Vincenza
- The journal of biochemistry 164(4), 313-322, 2018-10
- NAID 40021702561
★リンクテーブル★
[★]
アデニンヌクレオチドトランスロカーゼ、アデニンヌクレオチド輸送体、アデニンヌクレオチド交換輸送体
- 関
- mitochondrial ADP-ATP translocase
[★]
アデニンヌクレオチドトランスロケーター1
- 関
- ANT1
[★]
アデニンヌクレオチドトランスロケーター2
- 関
- ANT2
[★]
アデニンヌクレオチドトランスロケーター3
- 関
- ANT3