WordNet

a printer that automatically prints addresses on letters for mailing (同)Addressograph
the stance assumed by a golfer in preparation for hitting a golf ball
(computer science) the code that identifies where a piece of information is stored (同)computer address, reference
written directions for finding some location; written on letters or packages that are to be delivered to that location (同)destination, name and address
the act of delivering a formal spoken communication to an audience; "he listened to an address on minor Roman poets" (同)speech
a sign in front of a house or business carrying the conventional form by which its location is described
the manner of speaking to another individual; "he failed in his manner of address to the captain"
the place where a person or organization can be found or communicated with
direct a question at someone
speak to someone (同)accost, come up to
greet, as with a prescribed form, title, or name; "He always addresses me with `Sir"; "Call me Mister"; "She calls him by first name" (同)call
put an address on (an envelope) (同)direct
give a speech to; "The chairman addressed the board of trustees" (同)speak
speak to; "He addressed the crowd outside the window" (同)turn_to
access or locate by address
address or apply oneself to something, direct ones efforts towards something, such as a question
adjust and aim (a golf ball) at in preparation of hitting

PrepTutorEJDIC

〈C〉『あて名』,住所 / 〈C〉『演説』;(口頭・文書による)あいさつの言葉(speech) / 《文》〈U〉話しぶり,応対のしかた / 〈U〉(物事を扱う)手ぎわのよさ,如才なさ / 《複数形で》くどき,求愛,求婚 / …‘に'『あてて手紙』(『小包』)『を出す』 / (人にあてて)…‘の'あて名を書いて出す《+『名』+『to』+『名』〈人〉》 / (…と)〈人〉‘に'『話にかける』,呼びかける《+『名』+『as』+『名』》 / …‘に'演説する,講演する / (…に)〈抗議など〉'を'向ける《+『名』+『to』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/10 07:35:11」(JST)

wiki en

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.^[1]^[2]^[3]

Addressin is an extracellular protein of the endothelium of venules. Addressins are the ligands to the homing receptors of lymphocytes.^[4] The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by L-selectin.

Function

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.^[1]

References

^ ^a ^b "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1".
^ Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". J. Immunol. 156 (8): 2851–7. PMID 8609404.
^ Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KH, Krissansen GW (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097.
^ Addressin at eMedicine Dictionary

External links

vascular addressins at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 関節内および軟部組織注射：注射剤の種類および投与頻度intraarticular and soft tissue injections what agents to inject and how frequently [show details]
…protein drugs within the injected joint . As an example, complement receptor-1 linked to a membrane addressin successfully downregulated inflammation in the adjuvant arthritis rat model . The choice of different…
2. 炎症性腸疾患に伴う関節炎の治療treatment of arthritis associated with inflammatory bowel disease [show details]
…disease. By contrast, vedolizumab, a monoclonal antibody that binds the alpha4/beta7-mucosal vascular addressin cell adhesion molecule 1 (MadCAM) complex in the gut, is effective in reducing the gastrointestinal…
3. 脊椎関節炎の病因pathogenesis of spondyloarthritis [show details]
…integrin, which can function as a homing receptor. The ligand for this integrin is mucosal vascular addressin cell adhesion molecule 1 (MADCAM1), which, in patients with AS, is strongly expressed in the high…
4. 炎症の病因における白血球内皮細胞接着leukocyte endothelial adhesion in the pathogenesis of inflammation [show details]
…(IgG1) mAb against alpha-4-beta-7 integrin that interferes only with the alpha-4-beta-7/mucosal addressin cell adhesion molecule-1 (MAdCAM-1) interaction. It is therefore believed that the effect of vedolizumab…
5. 肥満細胞：増殖・分化、識別、および生理学的役割mast cells development identification and physiologic roles [show details]
…directs migration of MCps into normal intestine and inflamed lung. Alpha-4-beta-7 recognizes mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and vascular cell adhesion molecule-1 (VCAM-1, CD106), both…

English Journal

Absence of Nkx2-3 Homeodomain Transcription Factor Reprograms the Endothelial Addressin Preference for Lymphocyte Homing in Peyer's Patches.

Kellermayer Z1, Mihalj M2, Lábadi A3, Czömpöly T4, Lee M5, O'Hara E6, Butcher EC7, Berta G8, Balogh A8, Arnold HH9, Balogh P10.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Oct 15. pii: 1402016. [Epub ahead of print]
Although the homing of lymphocytes to GALT has been extensively studied, little is known about how high endothelial venules (HEVs) within Peyer's patches (PPs) are patterned to display dominantly mucosal addressin cell adhesion molecule 1 (MAdCAM-1). In this study, we report that Nkx2-3-deficient mi
PMID 25320278

Mucosal addressin cell adhesion molecule-1 of rhesus macaques: molecular cloning, expression, and alteration after viral infection.

Wang Y1, Yao WR, Duan JZ, Xu W, Yang GB.
Digestive diseases and sciences.Dig Dis Sci.2014 Oct;59(10):2433-43. doi: 10.1007/s10620-014-3209-0. Epub 2014 May 15.
BACKGROUND: Mucosal addressin cell adhesion molecule-1 (MAdCAM-1), a member of the immunoglobulin superfamily, is essential for gut-specific homing of leukocytes; however, it has not been well characterized in rhesus macaques.AIMS: To obtain the complete nucleotide sequence of rhesus macaque MAdCAM-
PMID 24828920

Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells and Treatment Algorithms for Inflammatory Bowel Diseases.

Danese S1, Panés J2.
Gastroenterology.Gastroenterology.2014 Sep 16. pii: S0016-5085(14)01087-7. doi: 10.1053/j.gastro.2014.08.044. [Epub ahead of print]
Increased understanding of the pathogenesis of inflammatory bowel diseases (IBDs) has led to new therapeutic strategies. One of these is to target the molecules that regulate interactions between leukocytes and endothelial cells at sites of inflammation (mainly leukocyte integrins and endothelial ce
PMID 25220794

Japanese Journal

アレルギー性鼻炎の発症とNALTの血管アドレシン

川島博人
臨床免疫・アレルギー科 57(6), 693-700, 2012-06
NAID 40019365697

Alimentary Tract マウスにおけるMAdCAM-1による形質細胞の小腸への遊走と機能発現の制御

藤山佳秀 [訳],Schippers Angela,Leuker Christoph [他]
Review of gastroenterology & clinical gastroenterology and hepatology 4(4), 21-25, 2010-02
NAID 40016992870

Related Pictures

★リンクテーブル★

リンク元	「アドレシン」
関連記事	「address」

「アドレシン」

MADCAM1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1BQS, 1GSM, 4HBQ, 4HC1, 4HCR, 4HD9
Identifiers
Aliases	MADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDs	GeneCards: 8174
Gene ontology
Molecular function	• integrin binding involved in cell-matrix adhesion;
Cellular component	• integral component of membrane; • plasma membrane; • membrane;
Biological process	• leukocyte tethering or rolling; • integrin-mediated signaling pathway; • heterotypic cell-cell adhesion; • aging; • cell adhesion; • cell-matrix adhesion; • extracellular matrix organization; • receptor clustering; • immune response; • signal transduction; • positive regulation of leukocyte migration; • regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	8174
	n/a
	ENSG00000099866
	n/a
	Q13477
	n/a
	NM_130762; NM_130760
	n/a
	NP_570116.2; NP_570118.1
	n/a
	Wikidata
View/Edit Human

　　[★]

英: addressin

血管内皮細胞にあってリンパ球定着に関与するタンパク質

「address」

　　[★]

n.

(口頭・書面での公式的な)あいさつ(の言葉)(formal speech)。演説、公園
あて先、住所、所番地。上書き
(コンピュータ)アドレス、番地
呼びかけ、呼称
(正式)手際よさ、器用さ
(正式)請願、請求(appeal)。建白書
(米)(大統領の)教書。
(米法)解任請求
(部品・組み立て品の)はめ込み、配置
(ゴルフ)アドレス(球を打つ構えを取ること、またはその姿勢)

vt.

(正式)(SVO)～を(～と)敬称で呼ぶ(as)
(手紙・封筒など)にあて先を書く、上書きする。(米)～に手紙を書く
(正式)～を(～に向けて)(じかに)言う、書く(express)。～を(～に)提出する(to)。～を申し入れる
(物・事)に焦点を当てる、的をしぼる、(課題など)に取り組む。(問題など)を扱う、処理する

A randomized controlled trial would definitively address this issue.(PMID 20151782)(ランダム化比較試験は間違いなく(決定的に)この論文に焦点を当てるであろう・・・　←すごい自信ですね)

(商業)(船など)を(～に)付託する、委託する(to)
(ゴルフ)(ボール)にアドレスする。(ダンス)(パートナー)に構えの姿勢を取る。(アーチェリー)(的)をねらう
(コンピュータ)(データ)をアドレスする
(法律)(立法部からの要請により)(行政部が)(裁判官)を解任する

関: embark

[entrez-1] "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1".

[pmid8609404-2] Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". J. Immunol. 156 (8): 2851–7. PMID 8609404.

[pmid9162097-3] Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KH, Krissansen GW (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097.

[4] Addressin at eMedicine Dictionary

匿名

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案内

案内

addressin