WordNet
- a result; "this situation developed in response to events in Africa"
- a phrase recited or sung by the congregation following a versicle by the priest or minister
- the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
- having a capacity for adaptation; "the adaptive coloring of a chameleon" (同)adaptative
PrepTutorEJDIC
- 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
- 適応できる,適応性のある
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/08 10:45:24」(JST)
[Wiki en表示]
The adaptive response is a form of direct DNA repair in E. coli that is initiated against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA. Under sustained exposure to low-level treatment with alkylating mutagens, E. coli can adapt to the presence of the mutagen, rendering subsequent treatment with high doses of the same agent less effective.[1]
The adaptive response is mediated by the ada protein (a part of the Ada regulon), which covalently transfers alkyl groups from the damaged DNA to one of its two cysteine residues, rendering the protein enzymatically dead. It is thus a "suicide" protein that reacts stoichiometrically rather than catalytically. Methylated ada acts as a transcription factor to initiate the adaptive response, promoting the expression of related genes such as alkA, alkB, aidB, and ada itself. The alkA gene product is a glycosylase,[1] the aidB product is a flavin-containing protein,[2] and alkB is an iron-dependent oxidoreductase;[3] all are involved in further DNA repairs of alkylation damage.
References
- ^ a b Volkert MR. (1988). Adaptive response of Escherichia coli to alkylation damage. Environ Mol Mutagen 11(2):241-55.
- ^ Rohankhedkar MS, Mulrooney SB, Wedemeyer WJ, Hausinger RP. (2006). The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein. J Bacteriol 188(1):223-30.
- ^ Yu B, Edstrom WC, Benach J, Hamuro Y, Weber PC, Gibney BR, Hunt JF. (2006). Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature 439(7078):879-84.
UpToDate Contents
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- Asahina Masashi,Satoh Shinobu
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- NAID 120005613869
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★リンクテーブル★
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- 関
- accommodate、accommodation、adapt、adaptability、adaptation、orientate
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