English Journal

Synthesis and Preliminary Evaluation of N-(16-[18F]fluorohexadecanoyl)ethanolamine (18F-FHEA) as a PET Probe of N-Acylethanolamine Metabolism in Mouse Brain.

Pandey MK, DeGrado TR, Qian K, Jacobson MS, Hagan CE, Duclos RI, Gatley SJ.
ACS chemical neuroscience.ACS Chem Neurosci.2014 Jul 8. [Epub ahead of print]
N-acylethanolamines are lipid signaling molecules found throughout the plant and animal kingdoms. The best-known mammalian compound of this class is anandamide, N-arachidonoylethanolamine, one of the endogenous ligands of cannabinoid CB1 and CB2 receptors. Signaling by N-acylethanolamines is termina
PMID 25003845

3-Aminoazetidin-2-one Derivatives as N-Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration.

Fiasella A1, Nuzzi A, Summa M, Armirotti A, Tarozzo G, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D.
ChemMedChem.ChemMedChem.2014 Jul;9(7):1602-14. doi: 10.1002/cmdc.201300546. Epub 2014 May 14.
N-Acylethanolamine acid amidase (NAAA) is a cysteine hydrolase that catalyzes the hydrolysis of endogenous lipid mediators such as palmitoylethanolamide (PEA). PEA has been shown to exert anti-inflammatory and antinociceptive effects in animals by engaging peroxisome proliferator-activated receptor�
PMID 24828120

A short-type peptidoglycan recognition protein from the silkworm: expression, characterization and involvement in the prophenoloxidase activation pathway.

Chen K1, Liu C1, He Y2, Jiang H2, Lu Z3.
Developmental and comparative immunology.Dev Comp Immunol.2014 Jul;45(1):1-9. doi: 10.1016/j.dci.2014.01.017. Epub 2014 Feb 6.
Recognition of invading microbes as non-self is the first step of immune responses. In insects, peptidoglycan recognition proteins (PGRPs) detect peptidoglycans (PGs) of bacterial cell wall, leading to the activation of defense responses. Twelve PGRPs have been identified in the silkworm, Bombyx mor
PMID 24508981