WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
inflammation of the colon (同)inflammatory_bowel_disease
of or relating to or characterized by ulceration; "ulcerative colitis"

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
結腸炎

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Martin JC1,2,3, Bériou G4, Josien R4,5,6.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1371:197-203. doi: 10.1007/978-1-4939-3139-2_12.
Inflammatory bowel diseases (IBDs) are complex multifactorial disease thought to result from inappropriate immune responses to the gut microbiota, in genetically susceptible individuals, under the influence of environmental factors. Among the different animal models developed to help in understandin
PMID 26530802

Lack of TNFRI signaling enhances annexin A1 biological activity in intestinal inflammation.

Sena AA1, Pedrotti LP1, Barrios BE1, Cejas H1, Balderramo D2, Diller A3, Correa SG4.
Biochemical pharmacology.Biochem Pharmacol.2015 Dec 1;98(3):422-31. doi: 10.1016/j.bcp.2015.09.009. Epub 2015 Sep 16.
We evaluated whether the lack of TNF-α signaling increases mucosal levels of annexin A1 (AnxA1); the hypothesis stems from previous findings showing that TNF-α neutralization in Crohn's disease patients up-regulates systemic AnxA1 expression. Biopsies from healthy volunteers and patients under ant
PMID 26386311

Halaweish I1, Alam HB2.
Journal of intensive care medicine.J Intensive Care Med.2015 Dec;30(8):451-61. doi: 10.1177/0885066614534941. Epub 2014 May 22.
Severe colitis, an umbrella encompassing several entities, is one of the most common acute gastrointestinal disorders resulting in critical illness. Clostridium difficile infection is responsible for the majority of nosocomial diarrhea with fulminant C difficile colitis (CDC) carrying a high mortali
PMID 24859995