急性単球性白血病
WordNet
- of critical importance and consequence; "an acute (or critical) lack of research funds"
- having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
- extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
- having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
- of an angle; less than 90 degrees
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
PrepTutorEJDIC
- (先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
- 白血病
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/26 09:47:48」(JST)
[Wiki en表示]
| Acute monocytic leukemia |
| Classification and external resources |
| Specialty |
Hematology and oncology |
| ICD-10 |
C93.0 |
| ICD-9-CM |
206.0 |
| MeSH |
D007948 |
Acute monocytic leukemia (AMoL, or AML-M5)[1] is considered a type of acute myeloid leukemia.
Contents
- 1 Diagnosis
- 2 Causes
- 3 Treatment
- 4 References
- 5 External links
Diagnosis
In order to fulfill World Health Organization (WHO) criteria for AML-5, a patient must have greater than 20% blasts in the bone marrow, and of these, greater than 80% must be of the monocytic lineage. A further subclassification (M5a versus M5b) is made depending on whether the monocytic cells are predominantly monoblasts (>80%) (acute monoblastic leukemia) or a mixture of monoblasts and promonocytes (<80% blasts). Monoblasts can be distinguished by having a roughly circular nucleus, delicate lacy chromatin, and abundant, often basophilic cytoplasm. These cells may also have pseudopods. By contrast, promonocytes have a more convoluted nucleus, and their cytoplasm may contain metachromatic granules. Monoblasts are typically MPO-negative and promonocytes are MPO variable. Both monoblasts and promonocytes stain positive for non-specific esterase (NSE), however NSE may often be negative.
Immunophenotypically, M5-AML variably express myeloid (CD13, CD33) and monocytic (CD11b, CD11c) markers. Cells may aberrantly express B-cell marker CD20 and the NK marker CD56. Monoblasts may be positive for CD34.
Causes
M5 is associated with characteristic chromosomal abnormalities, often involving Chromosome 11 at 11q23 or t(9;11) affecting the MLL locus, however the MLL translocation is also found in other AML subtypes. MLL is believed to be prognostically unfavorable in AML-M5 compared to other genetic alterations involving MLL such as t(9;11). The t(8;16) translocation in MLL is associated with hemophagocytosis.
Secondary leukaemia, which may include AML-M5, has been associated with exposure to epipodophyllotoxins, such as etoposide.[2]
Treatment
AML-M5 is treated with intensive chemotherapy (such as anthracyclines) or with bone marrow transplantation.
References
- ^ "Acute Myeloid Leukemia - Signs and Symptoms".
- ^ Kollmannsberger, C. et al. (Oct 1998). "Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumors.". J. Clin. Oncol. (16(10)): 3386–91.
External links
- Images at Nagoya University
- Image at hmds.org.uk
- Histology at University of Virginia
- Overview at Marist College
|
Diseases of RBCs and megakaryocytes / MEP (D50–69,74, 280–287)
|
|
Red
blood cells |
| ↑ |
|
|
| ↓ |
| Anemia |
| Nutritional |
- Micro-: Iron-deficiency anemia
- Macro-: Megaloblastic anemia
|
|
Hemolytic
(mostly normo-) |
| Hereditary |
- enzymopathy: G6PD
- glycolysis
- hemoglobinopathy: Thalassemia
- Sickle-cell disease/trait
- HPFH
- membrane: Hereditary spherocytosis
- Minkowski–Chauffard syndrome
- Hereditary elliptocytosis
- Southeast Asian ovalocytosis
- Hereditary stomatocytosis
|
|
| Acquired |
- Drug-induced autoimmune
- Drug-induced nonautoimmune
- Hemolytic disease of the newborn
|
|
|
Aplastic
(mostly normo-) |
- Hereditary: Fanconi anemia
- Diamond–Blackfan anemia
- Acquired: PRCA
- Sideroblastic anemia
- Myelophthisic
|
|
| Blood tests |
- MCV
- Normocytic
- Microcytic
- Macrocytic
- MCHC
|
|
|
| Other |
- Methemoglobinemia
- Sulfhemoglobinemia
- Reticulocytopenia
|
|
|
|
Coagulation/
coagulopathy |
| ↑ |
Hyper-
coagulability |
- primary: Antithrombin III deficiency
- Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden
- Prothrombin G20210A
- Sticky platelet syndrome
- acquired:Thrombocytosis
- DIC
- Congenital afibrinogenemia
- Purpura fulminans
- autoimmune
|
|
|
| ↓ |
Hypo-
coagulability |
| Thrombocytopenia |
- Thrombocytopenic purpura: ITP
- TM
- TTP
- Upshaw Schulman syndrome
- Heparin-induced thrombocytopenia
- May–Hegglin anomaly
|
|
| Platelet function |
- adhesion
- aggregation
- Glanzmann's thrombasthenia
- platelet storage pool deficiency
- Hermansky–Pudlak syndrome
- Gray platelet syndrome
|
|
| Clotting factor |
- Hemophilia
- von Willebrand disease
- Hypoprothrombinemia/II
- XIII
- Dysfibrinogenemia
|
|
|
|
|
|
Index of cells from bone marrow
|
|
| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
|
|
|
|
Myeloid hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
|
|
CFU-GM/
and other granulocytes |
| CFU-GM |
| Myelocyte |
| AML: |
- Acute myeloblastic leukemia
- M0
- M1
- M2
- APL/M3
|
|
| MP |
- Chronic neutrophilic leukemia
|
|
|
| Monocyte |
| AML |
- AMoL/M5
- Myeloid dendritic cell leukemia
|
|
| CML |
- Philadelphia chromosome
- Accelerated phase chronic myelogenous leukemia
|
|
|
| Myelomonocyte |
| AML |
|
|
| MD-MP |
- Juvenile myelomonocytic leukemia
- Chronic myelomonocytic leukemia
|
|
|
| Other |
|
|
|
| CFU-Baso |
|
|
| CFU-Eos |
| AML |
|
|
| MP |
- Chronic eosinophilic leukemia/Hypereosinophilic syndrome
|
|
|
|
| MEP |
| CFU-Meg |
|
|
| CFU-E |
| AML |
|
|
| MP |
|
|
| MD |
- Refractory anemia
- Refractory anemia with excess of blasts
- Chromosome 5q deletion syndrome
- Sideroblastic anemia
- Paroxysmal nocturnal hemoglobinuria
- Refractory cytopenia with multilineage dysplasia
|
|
|
|
| CFU-Mast |
| Mastocytoma |
- Mast cell leukemia
- Mast cell sarcoma
- Systemic mastocytosis
|
|
| Mastocytosis: |
- Diffuse cutaneous mastocytosis
- Erythrodermic mastocytosis
- Adult type of generalized eruption of cutaneous mastocytosis
- Urticaria pigmentosa
- Mast cell sarcoma
- Solitary mastocytoma
|
|
| Systemic mastocytosis |
- Xanthelasmoidal mastocytosis
|
|
|
| Multiple/unknown |
| AML |
- Acute panmyelosis with myelofibrosis
- Myeloid sarcoma
|
|
| MP |
- Myelofibrosis
- Acute biphenotypic leukaemia
|
|
|
|
Index of cells from bone marrow
|
|
| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
|
|
|
UpToDate Contents
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English Journal
- Eosinophilic dermatosis of hematologic malignancy.
- Farber MJ, La Forgia S, Sahu J, Lee JB.SourceJefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA Bay Dermatology, Toms River, NJ 08753, USA Department of Dermatology and Cutaneous Biology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
- Journal of cutaneous pathology.J Cutan Pathol.2012 Jul;39(7):690-5. doi: 10.1111/j.1600-0560.2012.01906.x. Epub 2012 May 22.
- Cutaneous involvement by an eosinophil-rich process (eosinophilic dermatosis) may be encountered in the setting of various hematologic malignancies, including mantle cell lymphoma, acute monocytic leukemia, acute lymphoblastic leukemia, large cell lymphoma, myelofibrosis and chronic lymphocytic leuk
- PMID 22612903
- Gottron's Papules Exhibit Dermal Accumulation of CD44 Variant 7 (CD44v7) and Its Binding Partner Osteopontin: A Unique Molecular Signature.
- Kim JS, Bashir MM, Werth VP.Source1] New York University School of Medicine, New York, New York, USA [2] Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA [3] Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- The Journal of investigative dermatology.J Invest Dermatol.2012 Jul;132(7):1825-32. doi: 10.1038/jid.2012.54. Epub 2012 Mar 29.
- The accumulated mucin in non-Gottron's dermatomyositis (DM) lesions is primarily chondroitin-4-sulfate (C4S), which is immunomodulatory in vitro. Gottron's papules are a particularly resistant manifestation of DM that often persist after other lesions have resolved with therapy. We examined non-Gott
- PMID 22456539
Japanese Journal
- Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
- 非ホジキンリンパ腫治療後に急性単球性白血病を合併した1例
- 杉田 馨里奈,八田 善弘,三浦 勝浩,栗田 大輔,小林 優人,田中 稔丈,石塚 光,竹井 和大,小林 寿美子,相澤 信,杉谷 雅彦,竹内 仁
- 日大醫學雜誌 69(3), 193-197, 2010-06-01
- NAID 10026989108
Related Links
- Acute monocytic leukemia Author: Doctor Arnauld C. Verschuur1 Creation date: May 2004 Scientific Editor: Professor Gilles Vassal 1Department of Pediatric Oncology, Academic Medical Centre, University of Amsterdam, Emma
- leukemia /leu·ke·mia/ (loo-ke´me-ah) a progressive, malignant disease of the blood-forming organs, marked by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow.leuke´mic acute ...
Related Pictures
★リンクテーブル★
[★]
- 英
- well differentiated acute monocytic leukemia, well differentiated form of acute monoblastic leukemia
- 同
- M5b 急性単球性白血病 acute monocytic leukemia
- 関
- 急性骨髄性白血病
[★]
[★]
- 英
- acute monoblastic leukemia
- 同
- M5a
- 関
- 急性単球性白血病 acute monocytic leukemia。M5
[★]
- 英
- acute monocytic leukemia AMoL
- 同
- M5
- 関
- 急性白血病、急性骨髄性白血病
[★]
末分化型急性単球性白血病
[★]
- (疾患)急性の、急性型の、急性的な。(形状が)鋭い、鋭角の。(感覚、才知などが)鋭い。明敏な、鋭い眼識のある。
- 関
- acutely、quick、sharp
[★]
- 関
- monocyte