WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
irregular and infrequent or difficult evacuation of the bowels; can be a symptom of intestinal obstruction or diverticulitis (同)irregularity

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
便秘

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1. 高齢者における便秘 constipation in the older adult
2. 幼児および小児における急性便秘の予防および治療 prevention and treatment of acute constipation in infants and children
3. 成人における慢性便秘のマネージメント management of chronic constipation in adults
4. 急性偽性腸閉塞（オギルビー症候群） acute colonic pseudo obstruction ogilvies syndrome
5. 小児における便秘：病因および診断 constipation in children etiology and diagnosis

Morphine dependence in single enteric neurons from the mouse colon requires deletion of β-arrestin2.

Smith TH, Ngwainmbi J, Hashimoto A, Dewey WL, Akbarali HI.
Physiological reports.Physiol Rep.2014 Sep 4;2(9). pii: e12140. doi: 10.14814/phy2.12140. Print 2014 Sep 1.
Chronic administration of morphine results in the development of tolerance to the analgesic effects and to inhibition of upper gastrointestinal motility but not to colonic motility, resulting in persistent constipation. In this study we examined the effect of chronic morphine in myenteric neurons fr
PMID 25194025

Comparison of an extended-release formulation of granisetron (APF530) versus palonosetron for the prevention of chemotherapy-induced nausea and vomiting associated with moderately or highly emetogenic chemotherapy: results of a prospective, randomized, double-blind, noninferiority phase 3 trial.

Raftopoulos H1, Cooper W, O'Boyle E, Gabrail N, Boccia R, Gralla RJ.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.Support Care Cancer.2014 Sep 2. [Epub ahead of print]
PURPOSE: Subcutaneous APF530 provides controlled sustained release of granisetron to prevent acute (0-24 h) and delayed (24-120 h) chemotherapy-induced nausea and vomiting (CINV). This randomized, double-blind phase 3 trial compared APF530 and palonosetron in preventing acute and delayed CINV afte
PMID 25179689

藤原一男
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 35(2), 129-135, 2012-04-28
視神経脊髄炎（Neuromyelitis Optica, NMO）は重度の視神経炎と横断性脊髄炎を特徴とする免疫性中枢神経疾患でありDevic病とも呼ばれてきた．NMOは女性に多く，重度の機能障害を遺し，脊髄病変は3椎体以上の長い病変を呈する．脳病変もまれではない．NMOと多発性硬化症（MS）の関係は長い間議論されてきたが，NMO患者の血中には疾患特異的な自己抗体（抗aqu …
NAID 10030573799

田畑拓久,小泉浩一,桑田剛,藤原崇,江頭秀人,藤原純子,稲葉良彦,荒川丈夫,門馬久美子,江川直人
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 54(4), 1477-1484, 2012-04-20
症例は46歳，女性．全身性エリテマトーデス（systemic lupus erythematosus；SLE）に対して長期間のステロイド治療が行われていた．血便を主訴に来院し，大腸内視鏡検査で急性出血性直腸潰瘍と診断された．長期臥床，慢性腎不全，糖尿病，宿便など複数の要因が発症に関与し，通常の止血処置では止血困難であったが，無水エタノール・エトキシスクレロール併用局注法にて止血し得た．難治性の出血 …
NAID 10030649625