English Journal

Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells.

Kamei C, Mio M, Yoshida T, Saito Y, Toyoda Y, Tsuriya Y.SourceDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama, University, Japan.
Arzneimittel-Forschung.Arzneimittelforschung.1997 Apr;47(4):390-4.
WP-871 (3'-(1H-tetrazol-5-yl)oxanilic acid monohydrate, CAS 114607-46-4) is a monohydrate of a main active metabolite of tazanolast (butyl 3'-(1H-tetrazol-5-yl) oxanilate, CAS 82989-25-1), an orally active antiallergic drug. WP-871 inhibited dose-dependently compound 48/80-induced histamine release
PMID 9150859

Inhibitory effect of aerosol WP871 on SRS-A mediated bronchoconstriction in the guinea pig in vivo.

Kurashima K, Fujimura M, Saito M, Sakamoto S, Miyake Y, Nishi K, Matsuda T.SourceThird Department of Internal Medicine, Kanazawa University School of Medicine, Japan.
Allergy.Allergy.1990 May;45(4):249-53.
Slow-reacting substance of anaphylaxis (SRS-A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS-A mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of inhaled WP871, a new anti-allergic drug
PMID 2382790