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Neumann WL, Coss E, Rugge M, Genta RM.SourceMiraca Life Sciences Research Institute, 6655 North MacArthur Boulevard, Irving, TX 75039, USA.
Nature reviews. Gastroenterology & hepatology.Nat Rev Gastroenterol Hepatol.2013 Jun 18. doi: 10.1038/nrgastro.2013.101. [Epub ahead of print]
Autoimmune gastritis is a chronic progressive inflammatory condition that results in the replacement of the parietal cell mass by atrophic and metaplastic mucosa. A complex interaction of autoantibodies against the parietal cell proton pump and sensitized T cells progressively destroy the parietal c
PMID 23774773

Interleukin-21 and tumor necrosis factor-α are critical for the development of autoimmune gastritis in mice.

Nishiura H, Iwamoto S, Kido M, Aoki N, Maruoka R, Ikeda A, Chiba T, Watanabe N.SourceDepartment of Gastroenterology and Hepatology, Kyoto University, Sakyo-ku, Kyoto, Japan; Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
Journal of gastroenterology and hepatology.J Gastroenterol Hepatol.2013 Jun;28(6):982-91. doi: 10.1111/jgh.12144.
BACKGROUND AND AIM: Autoimmune gastritis (AIG), an organ-specific autoimmune disease, is accompanied by achlorhydria, pernicious anemia, gastric carcinoid tumors, and gastric cancer. Patients with AIG initially respond to corticosteroids but have a great potential to relapse after treatment is withd
PMID 23425147

Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells.

Strickertsson JA, Desler C, Martin-Bertelsen T, Machado AM, Wadstrøm T, Winther O, Rasmussen LJ, Friis-Hansen L.SourceCenter for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
PloS one.PLoS One.2013 Apr 30;8(4):e63147. doi: 10.1371/journal.pone.0063147. Print 2013.
BACKGROUND: Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we
PMID 23646188