acetylserotonin methyltransferase

出典: meddic


acetylserotonin O-methyltransferase、hydroxyindole O-methyltransferase

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  • Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.
  • Veatch OJ1, Pendergast JS, Allen MJ, Leu RM, Johnson CH, Elsea SH, Malow BA.
  • Journal of autism and developmental disorders.J Autism Dev Disord.2015 Jan;45(1):100-10. doi: 10.1007/s10803-014-2197-4.
  • Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically unique
  • PMID 25059483
  • Salt stress-induced seedling growth inhibition coincides with differential distribution of serotonin and melatonin in sunflower seedling roots and cotyledons.
  • Mukherjee S1, David A, Yadav S, Baluška F, Bhatla SC.
  • Physiologia plantarum.Physiol Plant.2014 Dec;152(4):714-28. doi: 10.1111/ppl.12218. Epub 2014 Jun 11.
  • Indoleamines regulate a variety of physiological functions during the growth, morphogenesis and stress-induced responses in plants. Present investigations report the effect of NaCl stress on endogenous serotonin and melatonin accumulation and their differential spatial distribution in sunflower (Hel
  • PMID 24799301
  • Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O-methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations.
  • Lee HY1, Byeon Y, Lee K, Lee HJ, Back K.
  • Journal of pineal research.J Pineal Res.2014 Nov;57(4):418-26. doi: 10.1111/jpi.12181. Epub 2014 Oct 6.
  • Serotonin N-acetyltransferase (SNAT) is the penultimate enzyme in melatonin biosynthesis. We cloned SNAT from Arabidopsis thaliana (AtSNAT) and functionally characterized this enzyme for the first time from dicotyledonous plants. Similar to rice SNAT, AtSNAT was found to localize to chloroplasts wit
  • PMID 25250906


  • Hydroxyindole-O-methyltransferase activity assay using high-performance liquid chromatography with fluormetric detection : determination of melatonin enzymatically formed from N-acetylserotonin and S-adenosyl-L-methionine
  • ITOH Masanori T.,HATTORI Atsuhiko,SUMI Yawara
  • Journal of chromatography. B, Biomedical sciences and applications 692(1), 217-221, 1997-04-25
  • NAID 10024514486
  • Hydroxyindole-O-methyltransferase activity assay using high-performance liquid chromatography with fluorometric detection : determination of melatonin enzymatically formed from N-acetylserotonin and S-adenosyl-L-methionine
  • Effects of Dizepam Administration on Melatonin Synthesis in the Rat Pineal Gland in Vivo
  • 若林 広行,嶋田 健次,佐藤 哲男
  • Chemical & pharmaceutical bulletin 39(10), 2674-2676, 1991-10-25
  • … Subcutaneous injection of DZP (3 mg/kg) 1 h before the start of darkness significantly suppressed nocturnal elevations of pineal N-acetylserotonin (NAS) and melatonin contents in rats, and caused a 2-h delay in reaching the maximum melatonin level in the dark phase. …
  • NAID 110003628938


N-Acetylserotonin O-methyltransferase also known as ASMT is an enzyme that catalyzes the final reaction in melatonin biosynthesis, converting Normelatonin to melatonin. This reaction is embedded in the more general tryptophan metabolism pathway.
acetylserotonin N-methyltransferase, acetylserotonin methyltransferase (Y chromosome), hydroxyindole O-methyltransferase GeneRIFs: Gene References Into Functions These data suggest a relationship between decreased ...



リンク元hydroxyindole O-methyltransferase



acetylserotonin N-methyltransferase



acetylserotonin N-methyltransferase

hydroxyindole O-methyltransferase」



acetylserotonin methyltransferase、acetylserotonin O-methyltransferase