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English Journal

Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.

Veatch OJ1, Pendergast JS, Allen MJ, Leu RM, Johnson CH, Elsea SH, Malow BA.
Journal of autism and developmental disorders.J Autism Dev Disord.2015 Jan;45(1):100-10. doi: 10.1007/s10803-014-2197-4.
Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically unique
PMID 25059483

Salt stress-induced seedling growth inhibition coincides with differential distribution of serotonin and melatonin in sunflower seedling roots and cotyledons.

Mukherjee S1, David A, Yadav S, Baluška F, Bhatla SC.
Physiologia plantarum.Physiol Plant.2014 Dec;152(4):714-28. doi: 10.1111/ppl.12218. Epub 2014 Jun 11.
Indoleamines regulate a variety of physiological functions during the growth, morphogenesis and stress-induced responses in plants. Present investigations report the effect of NaCl stress on endogenous serotonin and melatonin accumulation and their differential spatial distribution in sunflower (Hel
PMID 24799301

Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O-methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations.

Lee HY1, Byeon Y, Lee K, Lee HJ, Back K.
Journal of pineal research.J Pineal Res.2014 Nov;57(4):418-26. doi: 10.1111/jpi.12181. Epub 2014 Oct 6.
Serotonin N-acetyltransferase (SNAT) is the penultimate enzyme in melatonin biosynthesis. We cloned SNAT from Arabidopsis thaliana (AtSNAT) and functionally characterized this enzyme for the first time from dicotyledonous plants. Similar to rice SNAT, AtSNAT was found to localize to chloroplasts wit
PMID 25250906

Hydroxyindole-O-methyltransferase activity assay using high-performance liquid chromatography with fluormetric detection : determination of melatonin enzymatically formed from N-acetylserotonin and S-adenosyl-L-methionine

ITOH Masanori T.,HATTORI Atsuhiko,SUMI Yawara
Journal of chromatography. B, Biomedical sciences and applications 692(1), 217-221, 1997-04-25
NAID 10024514486

Hydroxyindole-O-methyltransferase activity assay using high-performance liquid chromatography with fluorometric detection : determination of melatonin enzymatically formed from N-acetylserotonin and S-adenosyl-L-methionine

Effects of Dizepam Administration on Melatonin Synthesis in the Rat Pineal Gland in Vivo

若林広行,嶋田健次,佐藤哲男
Chemical & pharmaceutical bulletin 39(10), 2674-2676, 1991-10-25
… Subcutaneous injection of DZP (3 mg/kg) 1 h before the start of darkness significantly suppressed nocturnal elevations of pineal N-acetylserotonin (NAS) and melatonin contents in rats, and caused a 2-h delay in reaching the maximum melatonin level in the dark phase. …
NAID 110003628938