WordNet

receive substitution of an acetyl group; "the compounds acetylated" (同)acetylize, acetylise
introduce an acetyl group into (a chemical compound) (同)acetylize, acetylise
a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids

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Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease.

Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM.SourceAlzheimer Neurobiology Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Neurobiology of aging.Neurobiol Aging.2013 Sep;34(9):2081-90. doi: 10.1016/j.neurobiolaging.2012.12.028. Epub 2013 Apr 9.
Amyloid-β peptide (Aβ) fragment misfolding may play a crucial role in the progression of Alzheimer's disease (AD) pathophysiology as well as epigenetic mechanisms at the DNA and histone level. We hypothesized that histone H3 homeostasis is disrupted in association with the appearance of soluble A�
PMID 23582659

Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy.

Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L.SourceDipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Scienze Biochimiche, Policlinico Universitario, Via del Vespro, 129-90127 Palermo, Italy.
Journal of inorganic biochemistry.J Inorg Biochem.2013 Aug;125:16-25. doi: 10.1016/j.jinorgbio.2013.04.008. Epub 2013 Apr 25.
Three new triorganotin(IV) complexes of valproic acid (vp1, Me3Sn-valproate; vp2, Bu3Sn-valproate; vp3, Ph3Sn-valproate) have been synthesized and investigated by spectroscopic and biological methods. An anionic, monodentate valproate ligand was observed, ester-like coordinating the tin atom on a te
PMID 23685346

Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1.

Choi S, Lee YR, Park MS, Joo HK, Cho EJ, Kim HS, Kim CS, Park JB, Irani K, Jeon BH.SourceDepartment of Physiology, School of Medicine, Chungnam National University, Daejeon 301-747, Republic of Korea.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Jun 7;435(3):403-7. doi: 10.1016/j.bbrc.2013.04.101. Epub 2013 May 9.
Apurinic/apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) can be acetylated via post-translational modification. We investigated the effect of an inhibitor of histone deacetylases on the extracellular release of APE1/Ref-1 in HEK293 cells. Trichostatin A (TSA), an inhibitor of histone deacety
PMID 23665318

Okuda Kosaku,Ito Akihiro,Uehara Takashi
Biological and Pharmaceutical Bulletin 38(9), 1434-1437, 2015
… Histone deacetylase (HDAC) functions in the maintenance/balance of chromatin acetylation and contributes to transcriptional supression. … NO led to suppressed deacetylase activity in vitro and increased acetylated α-tubulin, a major substrate for HDAC6, in A549 cells. …
NAID 130005096977

Epigenetic Regulation of Resistance to Emotional Stress: Possible Involvement of 5-HT1A Receptor–Mediated Histone Acetylation

Tsuji Minoru,Miyagawa Kazuya,Takeda Hiroshi
Journal of Pharmacological Sciences 125(4), 347-354, 2014
… Studies with DNA microarray technology have revealed that histone deacetylase genes were decreased in the hippocampus of mice that had been pretreated with a 5-HT1A receptor agonist 24 h beforehand. … This preliminary finding was supported by data that hippocampal acetylated histone H3 was increased in mice that had developed emotional resistance to acute restraint stress by 5-HT1A receptor agonist. …
NAID 130004677801

Core Histone Charge and Linker Histone H1 Effects on the Chromatin Structure of Schizosaccharomyces pombe

PRIETO Eloise,HIZUME Kohji,KOBORI Toshiro,YOSHIMURA S. H.,TAKEYASU Kunio
Bioscience, Biotechnology, and Biochemistry 76(12), 2261-2266, 2012
… In particular, the histone tail regions of the fission yeast, Schizosaccharomyces pombe, have fewer lysine residues, making their charges less positive than those of higher eukaryotes. … pombe chromatin has a more open structure similar to reconstituted human acetylated chromatin. … pombe nucleosomal array formed thinner fibers than those of the human nucleosomal array in the presence of mammalian linker histone H1. …
NAID 130004137894