WordNet

a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/08 14:48:25」(JST)

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Acetophenazine (Tindal) is a typical antipsychotic of the phenothiazine class.^[1]

References[edit]

^ Current Psychotherapeutic Drugs - Google Books.

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English Journal

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs.

Bisson WH, Cheltsov AV, Bruey-Sedano N, Lin B, Chen J, Goldberger N, May LT, Christopoulos A, Dalton JT, Sexton PM, Zhang XK, Abagyan R.SourceDepartment of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2007 Jul 17;104(29):11927-32. Epub 2007 Jul 2.
Finding good drug leads de novo from large chemical libraries, real or virtual, is not an easy task. High-throughput screening is often plagued by low hit rates and many leads that are toxic or exhibit poor bioavailability. Exploiting the secondary activity of marketed drugs, on the other hand, may
PMID 17606915

Anticholinergic potency of psychoactive drugs in human and rat cerebral cortex and striatum.

Danielsson E, Peterson LL, Grundin R, Ogren SO, Bartfai T.AbstractThe affinity of selected antipsychotic and antidepressant drugs for the muscarinic receptor was studied in membranes from both human and rat striatum and cerebral cortex. While there are regional differences in the anticholinergic potency of the drugs, there is good agreement between the obtained inhibition constants from the corresponding human and rat striatum (r: 0.98) and from human and rat cerebral cortex (r: 0.96). There is also good agreement between the obtained Ki values within one species: human cerebral cortex versus human striatum (r: 0.99) and for rat cerebral cortex and rat striatum (r: 0.87). Thus, the previously published quantitative estimates of the antimuscarinic activity of psychoactive drugs which were derived from studies on membranes from rat brain give an accurate estimate of the antimuscarinic activity in human brain. The drugs tested in this study include chlorpromazine acetophenazine, haloperidol, sulpiride, remoxipride (FLA-731 (-), a substituted benzamide), amitriptyline and two serotonin uptake blockers: norzimelidine and alaproclate.
Life sciences.Life Sci.1985 Apr 15;36(15):1451-7.
The affinity of selected antipsychotic and antidepressant drugs for the muscarinic receptor was studied in membranes from both human and rat striatum and cerebral cortex. While there are regional differences in the anticholinergic potency of the drugs, there is good agreement between the obtained in
PMID 2858803

Related Pictures

★リンクテーブル★

リンク元	「アセトフェナジン」「マレイン酸アセトフェナジン」
関連記事	「maleate」「acetophenazine」

「アセトフェナジン」

Acetophenazine
Systematic (IUPAC) name
	1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-10H-phenothiazin-2-yl]ethanone
Clinical data
MedlinePlus	a600010
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	2751-68-0
ATC code	N05AB07
PubChem	CID 17676
DrugBank	DB01063
ChemSpider	16708
UNII	8620H6K4QH
ChEBI	CHEBI:2401
ChEMBL	CHEMBL1085
Chemical data
Formula	C23H29N3O2S
Mol. mass	411.561 g/mol
	SMILES O=C(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(CCO)CC4)C;
	InChI InChI=1S/C23H29N3O2S/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27/h2-3,5-8,17,27H,4,9-16H2,1H3 ; Key:WNTYBHLDCKXEOT-UHFFFAOYSA-N ;
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