acetophenazine

アセトフェナジン

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acetophenazine maleate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/01 05:34:38」(JST)

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Acetophenazine

Systematic (IUPAC) name
1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-10H-phenothiazin-2-yl]ethanone
Clinical data
MedlinePlus	a600010
Identifiers
CAS Number	2751-68-0 Y
ATC code	N05AB07 (WHO)
PubChem	CID 17676
DrugBank	DB01063 Y
ChemSpider	16708 Y
UNII	8620H6K4QH Y
ChEBI	CHEBI:2401 Y
ChEMBL	CHEMBL1085 Y
Chemical data
Formula	C23H29N3O2S
Molar mass	411.561 g/mol
SMILES O=C(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(CCO)CC4)C
InChI InChI=1S/C23H29N3O2S/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27/h2-3,5-8,17,27H,4,9-16H2,1H3 Y Key:WNTYBHLDCKXEOT-UHFFFAOYSA-N Y
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Acetophenazine (Tindal) is a typical antipsychotic of the phenothiazine class.

See also

• Typical antipsychotic
• Phenothiazine

References

UpToDate Contents

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• 1. 認知症に関連する行動症状の治療 treatment of behavioral symptoms related to dementia

English Journal

• Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs.

• Bisson WH1, Cheltsov AV, Bruey-Sedano N, Lin B, Chen J, Goldberger N, May LT, Christopoulos A, Dalton JT, Sexton PM, Zhang XK, Abagyan R.
• Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2007 Jul 17;104(29):11927-32. Epub 2007 Jul 2.
• Finding good drug leads de novo from large chemical libraries, real or virtual, is not an easy task. High-throughput screening is often plagued by low hit rates and many leads that are toxic or exhibit poor bioavailability. Exploiting the secondary activity of marketed drugs, on the other hand, may
• PMID 17606915

• Anticholinergic potency of psychoactive drugs in human and rat cerebral cortex and striatum.

• Danielsson E, Peterson LL, Grundin R, Ogren SO, Bartfai T.
• Life sciences.Life Sci.1985 Apr 15;36(15):1451-7.
• The affinity of selected antipsychotic and antidepressant drugs for the muscarinic receptor was studied in membranes from both human and rat striatum and cerebral cortex. While there are regional differences in the anticholinergic potency of the drugs, there is good agreement between the obtained in
• PMID 2858803

• Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

• Tam SW, Cook L.
• Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.1984 Sep;81(17):5618-21.
• The relationship between binding of antipsychotic drugs and sigma psychotomimetic opiates to binding sites for the sigma agonist (+)-[3H]SKF 10,047 (N-allylnormetazocine) and to dopamine D2 sites was investigated. In guinea pig brain membranes, (+)-[3H]SKF 10,047 bound to a single class of sites wit
• PMID 6147851

Related Links

• acetophenazine - The Pharmacogenomics Knowledge Base ...

Drug Description acetophenazine The phenothiazine decreases the effect of bromocriptine (source: Drug Bank) acetophenazine The phenothiazine decreases the effect of bromocriptine (source: Drug Bank)

• acetophenazine - definition of acetophenazine in the Medical ...

forum Join the Word of the Day Mailing List For webmasters TheFreeDictionary Google Bing? Word / Article Starts with Ends with Text ... acetophenazine a phenothiazine, similar to chlorpromazine, used as a tranquilizer.

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