アセノクマロール
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/19 00:56:33」(JST)
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Acenocoumarol
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Systematic (IUPAC) name |
(RS)-4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
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Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy
category |
|
Routes of
administration |
Oral |
Legal status |
Legal status |
- UK: POM (Prescription only)
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Pharmacokinetic data |
Metabolism |
Hepatic |
Biological half-life |
8 to 11 hours |
Identifiers |
CAS Number |
152-72-7 Y |
ATC code |
B01AA07 (WHO) |
PubChem |
CID 9052 |
DrugBank |
DB01418 Y |
ChemSpider |
10443441 Y |
UNII |
I6WP63U32H Y |
KEGG |
D07064 Y |
ChEBI |
CHEBI:53766 Y |
ChEMBL |
CHEMBL397420 Y |
Chemical data |
Formula |
C19H15NO6 |
Molar mass |
353.326 g/mol |
Chirality |
Racemic mixture |
SMILES
-
[O-][N+](=O)c1ccc(cc1)C(CC(C)=O)C\2=C(/O)c3ccccc3OC/2=O
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InChI
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InChI=1S/C19H15NO6/c1-11(21)10-15(12-6-8-13(9-7-12)20(24)25)17-18(22)14-4-2-3-5-16(14)26-19(17)23/h2-9,15,22H,10H2,1H3 Y
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Key:VABCILAOYCMVPS-UHFFFAOYSA-N Y
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Physical data |
Melting point |
196 to 199 °C (385 to 390 °F) |
(verify) |
Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.[1]
References
- ^ Drugs.com Drugs.com international listings for acenocoumarol
External links
- Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673–6. doi:10.1097/00001721-200412000-00007. PMID 15613922.
- Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619–21. PMID 15724697.
- Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227–46. doi:10.2165/00003088-200544120-00003. PMID 16372822.
- Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183–7. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310.
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
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Antiplatelet drugs |
Glycoprotein IIb/IIIa inhibitors |
- Abciximab
- Eptifibatide
- Tirofiban
- Roxifiban
- Orbofiban
|
|
ADP receptor/P2Y12 inhibitors |
- Thienopyridines
- Clopidogrel
- Prasugrel
- Ticlopidine
- Nucleotide/nucleoside analogs
- Cangrelor
- Elinogrel
- Ticagrelor
|
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Prostaglandin analogue (PGI2) |
- Beraprost
- Iloprost
- Prostacyclin
- Treprostinil
|
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COX inhibitors |
- Acetylsalicylic acid/Aspirin#
- Aloxiprin
- Carbasalate calcium
- Indobufen
- Triflusal
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Thromboxane inhibitors |
- Thromboxane synthase inhibitors
- Dipyridamole (+Aspirin)
- Picotamide
- Receptor antagonists
|
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Phosphodiesterase inhibitors |
- Cilostazol
- Dipyridamole
- Triflusal
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Other |
- Cloricromen
- Ditazole
- Vorapaxar
|
|
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Anticoagulants |
Vitamin K antagonists
(inhibit II, VII, IX, X) |
- Coumarins: Acenocoumarol
- Coumatetralyl
- Dicoumarol
- Ethyl biscoumacetate
- Phenprocoumon
- Warfarin#
- 1,3-Indandiones: Clorindione
- Diphenadione
- Phenindione
- Other: Tioclomarol
|
|
Factor Xa inhibitors
(with some II inhibition) |
Heparin group/
glycosaminoglycans/
(bind antithrombin) |
- Low molecular weight heparin
- Bemiparin
- Certoparin
- Dalteparin
- Enoxaparin
- Nadroparin
- Parnaparin
- Reviparin
- Tinzaparin‡
- Oligosaccharides
- Fondaparinux
- Idraparinux§
- Heparinoids
- Danaparoid
- Dermatan sulfate
- Sulodexide
|
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Direct Xa inhibitors |
- Xabans
- Apixaban
- Betrixaban†
- Darexaban§
- Edoxaban
- Otamixaban§
- Rivaroxaban
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Direct thrombin (IIa) inhibitors |
- Bivalent: Hirudin
- Bivalirudin
- Desirudin
- Lepirudin
- Univalent: Argatroban
- Dabigatran
- Melagatran‡
- Ximelagatran‡
|
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Other |
- Antithrombin III
- Defibrotide
- Protein C
- Ramatroban
- REG1
|
|
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Thrombolytic drugs/
fibrinolytics |
- Plasminogen activators: r-tPA
- Alteplase
- Reteplase
- Tenecteplase
- UPA
- Anistreplase
- Monteplase
- Streptokinase#
- Other serine endopeptidases: Ancrod
- Brinase
- Fibrinolysin
|
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Non-medicinal |
|
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Types of coumarins
|
|
Aglycones |
- Aesculetin
- Ferujol
- Umbelliferone
O-Methylated
|
- Fraxetin
- Herniarin (7-O-Methylumbelliferone)
- Osthol
- Scopoletin (6-Methoxyumbelliferone)
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|
|
glycosides |
- Aesculin (Esculetin 6-O-glucoside)
- Fraxin (Fraxetin glucoside)
- Skimmin (Umbelliferone 7-O-glucoside)
- Scopolin
- Umbelliferone 7-apiosylglucoside
|
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derivatives |
Furanocoumarins
|
Aglycones
|
- Angelicin
- Marmesin
- Psoralen
- Vaginol
- Xanthotoxol (8-Hydroxypsoralen)
O-Methylated
|
- Bergapten (5-methoxypsoralen)
- Isopimpinellin (5,8-Dimethoxypsoralene)
- Methoxsalen (8-Methoxypsoralen)
- Trioxsalen (2,5,9-Trimethylpsoralen)
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Furanocoumarin glycosides
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- Apterin (vaginol glucoside)
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Meroterpene furanocoumarin ether
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- Auraptene
- Bergamottin
- Imperatorin
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Oligomers |
|
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Synthetic |
- Acenocoumarol
- Coumatetralyl
- Ensaculin
- Ethyl biscoumacetate
- 4-Hydroxycoumarins
- Hymecromone
- Phenprocoumon
- Warfarin
|
UpToDate Contents
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English Journal
- [Measurement of d-dimers in non-valvular atrial fibrillation. First prospective Tunisian study].
- El Borgi W1, Romdhane S2, Sdiri W3, Longo S4, Hafsia R5, Boujnah MR6.
- Annales de cardiologie et d'angéiologie.Ann Cardiol Angeiol (Paris).2015 Sep;64(4):279-84. doi: 10.1016/j.ancard.2015.01.003. Epub 2015 Jan 16.
- Atrial fibrillation can expose to thrombo-embolic complications. Many biomarkers have been tested to refine the stratification of thrombo-embolic risk. The study aim was to assess the interest of the d-dimer testing in this pathology. We conducted a prospective observational study including 50 case
- PMID 25617058
- Adequacy of preadmission oral anticoagulation with vitamin K antagonists and ischemic stroke severity and outcome in patients with atrial fibrillation.
- Tziomalos K1, Giampatzis V, Bouziana SD, Spanou M, Kostaki S, Papadopoulou M, Dourliou V, Sofogianni A, Savopoulos C, Hatzitolios AI.
- Journal of thrombosis and thrombolysis.J Thromb Thrombolysis.2015 Aug 8. [Epub ahead of print]
- It is unclear whether vitamin K antagonists affect stroke severity and outcome in patients with atrial fibrillation (AF). We aimed to evaluate this association. We prospectively studied 539 consecutive patients admitted with acute ischemic stroke (41.2 % males, age 78.9 ± 6.6 years). The severi
- PMID 26253707
- Antithrombotic strategy after bioprosthetic aortic valve replacement in patients in sinus rhythm: evaluation of guideline implementation.
- van der Wall SJ1, Umans VA2, Schotten J3, Keijzers M4, Wolterbeek R5, Jansen EK6, Huisman MV7, Vonk AB6.
- European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.Eur J Cardiothorac Surg.2015 Aug 1. pii: ezv254. [Epub ahead of print]
- OBJECTIVES: After elective aortic valve replacement, patients are at risk of developing valve thrombosis and systemic arterial thromboembolism. Current guidelines recommend antithrombotic therapy with aspirin or vitamin K antagonists (VKAs) during the first 3 months after the procedure, but have lev
- PMID 26233944
Japanese Journal
- Fatal intoxications by acenocoumarol, phenprocoumon and warfarin : Method validation in blood using the total error approach
- DENOOZ Raphael,DOUAMBA Zoenabo,CHARLIER Corinne
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(23), 2344-2348, 2009-08-01
- NAID 10028021440
- A rapid method for the quantification of the enantiomers of Warfarin, Phenprocoumon and Acenocoumarol by two-dimensional-enantioselective liquid chromatography/electrospray tandem mass spectrometry
- VECCHIONE Gennaro,CASETTA Bruno,TOMAIUOLO Michela,GRANDONE Elvira,MARGAGLIONE Maurizio
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 850(1), 507-514, 2007-05-01
- NAID 10025798809
Related Links
- Acenocoumarolとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Acenocoumarolとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへ メール ...
- ニクマロン / アセノクマロール Acenocoumarol 錠はに効果のあるお薬です。気になる副作用などについてはこちらをご覧下さい。また、ニクマロン / アセノクマロール Acenocoumarol 錠 と同様効果のある他のお薬も多数取扱っております ...
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