aceclidine

アセクリジン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/21 23:16:01」(JST)

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Aceclidine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical (ophthalmic solution)
ATC code	S01EB08 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-Azabicyclo[2.2.2]oct-3-yl acetate
CAS Number	827-61-2 N 6109-70-2 (HCl)
PubChem CID	1979
ChemSpider	1902 Y
UNII	0578K3ELIO
KEGG	D02750 Y
ChEMBL	CHEMBL20835 Y
ECHA InfoCard	100.011.431
Chemical and physical data
Formula	C9H15NO2
Molar mass	169.221 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(OC2C1CCN(CC1)C2)C
InChI InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3 Y Key:WRJPSSPFHGNBMG-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Aceclidine (Glaucostat, Glaunorm, Glaudin) is a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma. It decreases intraocular pressure.

Adverse effects

Side effects of aceclidine include increased salivation and bradycardia (in excessive doses).

Mechanism of action

Aceclidine acts as a muscarinic acetylcholine receptor agonist.

See also

• Talsaclidine
• Vedaclidine

English Journal

• Role of nicotinic and muscarinic cholinoreceptors in the realization of the cholinergic anti-inflammatory pathway during the early phase of sepsis.

• Zabrodskii PF1, Lim VG, Shekhter MS, Kuzmin AV.
• Bulletin of experimental biology and medicine.Bull Exp Biol Med.2012 Sep;153(5):700-3.
• PMID 23113262

• Effectiveness of daily use of brimonidine as antimydriatic agent.

• Brown S.
• Journal of cataract and refractive surgery.J Cataract Refract Surg.2009 Oct;35(10):1845-6; author reply 1846. doi: 10.1016/j.jcrs.2009.06.016.
• PMID 19781497

• Role of cholinergic and cytokine regulation of T cell function in stimulation and inhibition of immune reactions in intoxication by organophosphorus compounds in different doses.

• Zabrodskii PF1, Kirichuk VF, Lim VG, Yafarova IH, Kuzmin AV.
• Bulletin of experimental biology and medicine.Bull Exp Biol Med.2009 Sep;148(3):399-402.
• PMID 20396698

Japanese Journal

• アセクリジン, ピロカルピンのヒト眼内平滑筋に対する薬理学的作用

• あたらしい眼科 = Journal of the eye 15(7), 983-985, 1998-07-30
• NAID 10018608933

• Inhibition of aceclidine-stimulated outflow facility, accommodation. and miosis in rhesus monkeys by muscarinic receptor antagonists

• Exp Eye Res 58, 623-630, 1994
• NAID 30019663023

• Dissociation between the effect of aceclidine on outflow facility and accommodation

• Exp Eye Res 50, 143-147, 1990
• NAID 30019665060