English Journal

[Acatalasemia and type 2 diabetes mellitus].

Góth L1, Nagy T1, Káplár M2.
Orvosi hetilap.Orv Hetil.2015 Mar 1;156(10):393-8. doi: 10.1556/OH.2015.30095.
in

English, HungarianA kataláz enzim a toxikus koncentrációjú hidrogén-peroxidot bontja oxigénné és vízzé. A hidrogén-peroxid egy kis molekulájú agresszív vegyület, amely a fehérjéket, a dezoxiribonukleinsavat, ribonukleinsavat és a lipideket károsíthatja. Az acatalasaemia a

PMID 25726767

Inherited catalase deficiency: is it benign or a factor in various age related disorders?

Góth L1, Nagy T.
Mutation research.Mutat Res.2013 Oct-Dec;753(2):147-54. doi: 10.1016/j.mrrev.2013.08.002. Epub 2013 Sep 8.
Hydrogen peroxide was - and is still - considered toxic for a wide range of living organisms. Oxidative stress occurs when there is an excess of pro-oxidants over antioxidants and it has been implicated in several diseases. Catalase is involved in hydrogen peroxide catabolism and is important in def
PMID 24025477

Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice.

Miller L1, Shapiro AM, Wells PG.
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2013 Aug;134(2):400-11. doi: 10.1093/toxsci/kft122. Epub 2013 Jun 2.
Reactive oxygen species (ROS) are implicated in fetal alcohol spectrum disorders (FASD) caused by alcohol (ethanol, EtOH). Although catalase detoxifies hydrogen peroxide, embryonic catalase activity is only about 5% of maternal levels. To determine the roles of ROS and embryonic catalase in FASD, pr
PMID 23733920

Japanese Journal

Acatalasemic mice are mildly susceptible to Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis

Takiue Keiichi,Sugiyama Hitoshi,Inoue Tatsuyuki,Morinaga Hiroshi,Kikumoto Yoko,Kitagawa Masashi,Kitamura Shinji,Maeshima Yohei,Wang Dahong,Masuoka Noriyoshi,Ogino Keiki,Makino Hirofumi
BMC Nephrology 13(14), 2012-05-25
… Methods: ADR was intravenously administered to both homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) and control wild-type mice (C3H/AnLCs(a)Cs(a)). … Results: The ADR-treated mice developed significant albuminuria and glomerulosclerosis, and the degree of these conditions in the ADR-treated acatalasemic mice was higher than that in the wild-type mice. … ADR induced progressive renal fibrosis, renal atrophy and lipid peroxide accumulation only in the acatalasemic mice. …
NAID 120005232483

Mammalian Acatalasemia: The Perspectives of Bioinformatics and Genetic Toxicology

Ogata Masana,Wang Da-Hong,Ogino Keiki
Acta Medica Okayama 62(6), 345-361, 2008-12
… The experimental research in genetic toxicology concerning the effect of oxidative stressors (nitrogen monoxide, nitrogen dioxide and so on) on Japanese acatalasemic blood and acatalasemic mice is described. …
NAID 120002305472

No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice

Nakagawa Shinya,Kataoka Takahiro,Mizuguchi Yuko,Yoshimoto Masaaki,Sakoda Akihiro,Nomura Takaharu,Wang Da-Hong,Kawabe Atsushi,Taguchi Takehito,Yamaoka Kiyonori
Journal of Clinical Biochemistry and Nutrition 43(1), 41-49, 2008-07
… To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. … Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. …
NAID 120004664366