abnormal prion protein

異常プリオン蛋白

WordNet

1. much greater than the normal; "abnormal profits"; "abnormal ambition"
2. not normal; not typical or usual or regular or conforming to a norm; "abnormal powers of concentration"; "abnormal amounts of rain"; "abnormal circumstances"; "an abnormal interest in food" (同)unnatural
3. departing from the normal in e.g. intelligence and development; "they were heartbroken when they learned their child was abnormal"; "an abnormal personality"
4. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
5. (microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system

PrepTutorEJDIC

1. 『異常な』,普通でない,規準をはずれた
2. 蛋白(たんばく)質

UpToDate Contents

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• 1. プリオンの生物学および遺伝学 biology and genetics of prions
• 2. クロイツフェルト・ヤコブ病 creutzfeldt jakob disease
• 3. プリオンによる中枢神経系疾患 diseases of the central nervous system caused by prions
• 4. 変異型クロイツフェルト・ヤコブ病 variant creutzfeldt jakob disease
• 5. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases

English Journal

• A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.

• Brehm N1, Bez F2, Carlsson T3,4, Kern B3, Gispert S1, Auburger G5, Cenci MA6.
• Molecular neurobiology.Mol Neurobiol.2015 Dec;52(3):1152-64. doi: 10.1007/s12035-014-8911-6. Epub 2014 Oct 12.
• Alpha-synuclein (SNCA) protein aggregation plays a causal role in Parkinson's disease (PD). The SNCA protein modulates neurotransmission via the SNAP receptor (SNARE) complex assembly and presynaptic vesicle trafficking. The striatal presynaptic dopamine deficit is alleviated by treatment with levod
• PMID 25307288

• The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α.

• O'Sullivan J1, Comerford E1, Rachidi W1, Scott M1, Hooper NM2, McMahon HE3.
• Biochimica et biophysica acta.Biochim Biophys Acta.2015 Nov;1850(11):2213-21. doi: 10.1016/j.bbagen.2015.08.010. Epub 2015 Aug 20.
• BACKGROUND: The neuronal adaptor protein X11α is a multidomain protein with a phosphotyrosine binding (PTB) domain, two PDZ (PSD_95, Drosophila disks-large, ZO-1) domains, a Munc Interacting (MI) domain and a CASK interacting region. Amongst its functions is a role in the regulation of the abnormal
• PMID 26297964

• Synthesis of double-fluorescent labeled prion protein for FRET analysis.

• Hosokawa-Muto J1, Yamaguchi K1,2, Kamatari YO1,3, Kuwata K1,2,4.
• Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2015 Nov;79(11):1802-9. doi: 10.1080/09168451.2015.1050991. Epub 2015 Jun 2.
• An abnormal form of prion protein (PrP) is considered to be the pathogen in prion diseases. However, the structural details of this abnormal form are not known. To characterize the non-native structure of PrP, we synthesized position-specific double-fluorescent labeled PrP for a fluorescence resonan
• PMID 26035019

Japanese Journal

• Conformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion

• Sano Kazunori,Atarashi Ryuichiro,Ishibashi Daisuke,Nakagaki Takehiro,Satoh Katsuya,Nishida Noriyuki
• Journal of Virology 88(20), 11791-11801, 2014-10
• … The phenomenon of prion strains with distinct biological characteristics has been hypothesized to be involved in the structural diversity of abnormal prion protein (PrPSc). …
• NAID 120005512154

• Comparison of the Anti-Prion Mechanism of Four Different Anti-Prion Compounds, Anti-PrP Monoclonal Antibody 44B1, Pentosan Polysulfate, Chlorpromazine, and U18666A, in Prion-Infected Mouse Neuroblastoma Cells

• Yamasaki Takeshi,Suzuki Akio,Hasebe Rie,Horiuchi Motohiro
• PLoS ONE 9(9), e106516, 2014-09-02
• … Molecules that inhibit the formation of an abnormal　isoform of prion protein (PrPSc) in prion-infected　cells are candidate therapeutic agents for prion　diseases. …
• NAID 120005476205

• Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein

• Homma Takujiro,Ishibashi Daisuke,Nakagaki Takehiro,Satoh Katsuya,Sano Kazunori,Atarashi Ryuichiro,Nishida Noriyuki
• Scientific Reports 4, 4504, 2014-03-28
• … Prion diseases are neurodegenerative disorders characterized by the aggregation of abnormally folded prion protein (PrP Sc). … p62 is a cytosolic protein known to mediate both the formation and degradation of aggregates of abnormal proteins. … The levels of p62 protein increased in prion-infected brains and persistently infected cell cultures. …
• NAID 120005438928

Related Links

• Early Detection of Abnormal Prion Protein in Genetic Human ...

Introduction Prion diseases (PrD) are fatal neurodegenerative disorders characterized by the accumulation of abnormal prion protein (PrP Sc) in the CNS. The genetic form of human PrD (gPrD) is caused by mutations in ...

• Proteolysis of abnormal prion protein with a thermostable ...

1. Appl Microbiol Biotechnol. 2013 Jul 24. [Epub ahead of print] Proteolysis of abnormal prion protein with a thermostable protease from Thermococcus kodakarensis KOD1. Koga Y, Tanaka SI, Sakudo A, Tobiume M, Aranishi M ...

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★リンクテーブル★

リンク元	「異常プリオン蛋白」
関連記事	「abnormal」「prion protein」

「異常プリオン蛋白」

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英

abnormal prion protein

「abnormal」

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• adj.

• 異常な、異常性の

関

aberrant、aberrantly、aberration、abnormality、abnormally、anomalous、anomalously、anomaly、defect、deviant、deviation、extraordinarily、extraordinary、unusual、unusually

　 　 　 　

「prion protein」

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同

PrP

同

PrP

同

PrP