abl gene

出典: meddic


abl oncogene、c-abl gene、c-abl proto-oncogene、v-abl gene、v-abl oncogene

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/19 12:40:57」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/14 07:37:27」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/09/26 15:59:56」(JST)

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  • Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr-Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells.
  • Trécul A, Morceau F, Gaigneaux A, Orsini M, Chateauvieux S, Grandjenette C, Dicato M, Diederich M.SourceLaboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, Rue Edward Steichen, 2540 Luxembourg, Luxembourg.
  • Cancer letters.Cancer Lett.2013 Oct 28;340(1):30-42. doi: 10.1016/j.canlet.2013.06.023. Epub 2013 Jun 26.
  • Constitutive activity of kinases has been reported in many types of cancers, so that inhibition of "onco-kinases" became a validated anti-cancer strategy. We found that the polyphenol 13c, a tri-vanillate derivative, inhibited kinase phosphorylation in leukemia cells. P-JAK2, P-Src and P-PI3Kp85 inh
  • PMID 23811288
  • Antagonistic functional duality of cancer genes.
  • Stepanenko AA, Vassetzky YS, Kavsan VM.SourceState Key Laboratory of Molecular and Cellular Biology, Institute of Molecular Biology and Genetics, 150 Zabolotnogo Street, Kyiv 03680, Ukraine. Electronic address: a.a.stepanenko@gmail.com.
  • Gene.Gene.2013 Oct 25;529(2):199-207. doi: 10.1016/j.gene.2013.07.047. Epub 2013 Aug 9.
  • Cancer evolution is a stochastic process both at the genome and gene levels. Most of tumors contain multiple genetic subclones, evolving in either succession or in parallel, either in a linear or branching manner, with heterogeneous genome and gene alterations, extensively rewired signaling networks
  • PMID 23933273
  • Apoptosis-antagonizing transcription factor (AATF) gene silencing: role in induction of apoptosis and down-regulation of estrogen receptor in breast cancer cells.
  • Sharma M.SourceDepartment of Biotechnology, Panjab University, Chandigarh, 160014, India, monika_sharma540@yahoo.com.
  • Biotechnology letters.Biotechnol Lett.2013 Oct;35(10):1561-70. doi: 10.1007/s10529-013-1257-8. Epub 2013 Jun 26.
  • Apoptosis-antagonizing transcription factor (AATF) is involved in transcriptional regulation, cell cycle control, DNA damage responses and in the execution of cell death programs. It also interacts directly with nuclear hormone receptors to enhance their transactivation. This study highlights the RN
  • PMID 23801113


  • 急性リンパ性白血病の分子機構
  • 玉井 勇人,猪口 孝一
  • 臨床血液 56(3), 253-260, 2015
  • … 小児急性リンパ性白血病acute lymphoblastic leukemia (ALL)は過去数十年あまりの間に治療成績は飛躍的に向上し,約90%の患者が長期生存できるようになったが,MLL-AF4陽性ALLやbcr-abl陽性ALLの予後は未だ十分でない。 …
  • NAID 130005065343
  • Severe Case of Peripheral Leukocytosis Initially Diagnosed as Myelodysplastic Syndrome/Myeloproliferative Neoplasm, Unclassifiable, but Possibly Prefibrotic Primary Myelofibrosis
  • Ota Seisuke,Hiramatsu Yasushi,Kondo Eisei,Kasahara Akinori,Takada Saimon,Umena Sachio,Noguchi Toshio,Tanimoto Mitsune,Matsumura Tadashi
  • Acta Medica Okayama 68(6), 363-368, 2014-12
  • … A fluorescence in situ hybridization test could not detect the BCR-ABL fusion gene. …
  • NAID 120005525314
  • Molecular analysis of the BCR-ABL1 kinase domain in chronic-phase chronic myelogenous leukemia treated with tyrosine kinase inhibitors in practice: Study by the Nagasaki CML Study Group
  • Itonaga Hidehiro,Tsushima Hideki,Imanishi Daisuke,Hata Tomoko,Doi Yuko,Mori Sayaka,Sasaki Daisuke,Hasegawa Hiroo,Matsuo Emi,Nakashima Jun,Kato Takeharu,Horai Makiko,Taguchi Masataka,Matsuo Masatoshi,Taniguchi Hiroaki,Makiyama Junnya,Sato Shinya,Horio Kensuke,Ando Koji,Moriwaki Yuji,Sawayama Yasushi,Ogawa Daisuke,Yamasaki Reishi,Takasaki Yumi,Imaizumi Yoshitaka,Taguchi Jun,Kawaguchi Yasuhisa,Yoshida Shinichiro,Joh Tatsuro,Moriuchi Yukiyoshi,Nonaka Hiroaki,Soda Hisashi,Fukushima Takuya,Nagai Kazuhiro,Kamihira Shimeru,Tomonaga Masao,Yanagihara Katsunori,Miyazaki Yasushi
  • Leukemia Research 38(1), 76-83, 2014-01
  • … An appropriate trigger for BCR-ABL1 mutation analysis has not yet been established in unselected cohorts of chronic-phase chronic myelogenous leukemia patients. … Univariate analysis revealed that significant factors associated with not attaining a major molecular response (MMR) were the presence of the minor BCR-ABL1 fusion gene, a low daily dose of TKI, and the emergence of BCR-ABL1 kinase domain mutations conferring resistance to imatinib. …
  • NAID 120005367584


Complete information for ABL1 gene (Protein Coding), ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... ...
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is ...


BCR ABL Gene | Woning Ontwerp VoorbeeldenGleevec – The Dawn of Targeted Therapy the discovery in philadelphia in 1960 of Alberts B, Molecular Biology of the CellGenes abl (Genes c-abl; Genes v-abl)Genes Abl (Genes c-abl; Genes v-abl)

拡張検索c-abl gene」「v-abl gene



abl gene

c-abl gene」



abl gene、abl oncogene、c-abl proto-oncogene、v-abl gene、v-abl oncogene

v-abl gene」



abl gene、abl oncogene、c-abl gene、c-abl proto-oncogene、v-abl oncogene


  [★] 遺伝子

WordNet   license wordnet

「(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"」
cistron, factor

PrepTutorEJDIC   license prepejdic




WordNet   license wordnet

「informal term for information; "give me the gen on your new line of computers"」