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English Journal

Nine new diterpenes from the leaves of plantation-grown Cunninghamia lanceolata.

Zhao S1, Ling J2, Li Z3, Wang S4, Hu J5, Wang N6.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Apr 1;25(7):1483-9. doi: 10.1016/j.bmcl.2015.02.026. Epub 2015 Feb 19.
Nine new diterpenes named lanceolatanol hydroperoxide (1), epilanceolatanol hydroperoxide (2), lanceolatanoic acid hydroperoxide (3), epilanceolatanoic acid hydroperoxide (4), lanceolatanol (5), lanceolatanoic acid (6), 11-acetoxylanceolatanoic acid (7), 11-acetoxylanceolatanoic acid methyl ester (8
PMID 25736997

Hirata A1, Kim SY2, Kobayakawa N1, Tanaka N1, Kashiwada Y3.
Fitoterapia.Fitoterapia.2015 Apr;102:49-55. doi: 10.1016/j.fitote.2015.01.013. Epub 2015 Jan 30.
Constituents of the anti-influenza A neuraminidase (NA) active extract from Radix Salviae miltiorrhizae were investigated, resulting in the isolation of four new diterpenes, miltiorins A-D (1-4), together with eight known diterpenes. The structures of 1-4 were assigned by spectroscopic analysis. Mil
PMID 25644525

Janus kinase/signal transducer and activator of transcription inhibitors enhance the protective effect mediated by tanshinone IIA from hypoxic/ischemic injury in cardiac myocytes.

Zhang MQ1, Tu JF1, Chen H1, Shen Y1, Pang LX1, Yang XH1, Sun RH1, Zheng YL1.
Molecular medicine reports.Mol Med Rep.2015 Apr;11(4):3115-21. doi: 10.3892/mmr.2014.3063. Epub 2014 Dec 9.
Tanshinone IIA is a lipophilic abietane diterpene compound, which exhibits protective effects against ischaemia/reperfusion injury; however, the pathways responsible for the myocardial protective activities of tanshinone IIA remain to be elucidated. The aim of the present study was to investigate th
PMID 25502794

Syntheses and Antibacterial Activities of Diterpene Catechol Derivatives with Abietane, Totarane and Podocarpane Skeletons against Methicillin-Resistant Staphylococcus aureus and Propionibacterium acnes

Tada Masahiro,Kurabe Jun,Yoshida Takashi,Ohkanda Tomoyuki,Matsumoto Yusuke
Chemical and Pharmaceutical Bulletin 58(6), 818-824, 2010
… Natural catechol, quinone and quinone methide diterpenes with abietane (15-deoxyfuerstione, taxodione) and totarane (dispermone, 12,13-dihydroxy-8,11,13-totaratriene-6-one), and podocarpane (nimbidiol, deoxynimbidiol) skeletons were synthesized using ortho-oxidation of phenol with meta-chlorobenzoyl peroxide. …
NAID 130000255854

SATO Kimihiko,SUGAWARA Keito,TAKEUCHI Hirono,PARK Hyun-Sun,AKIYAMA Toshiyuki,KOYAMA Tetsuo,AOYAGI Yutaka,TAKEYA Koichi,TSUGANE Takanori,SHIMURA Susumu
Chemical & pharmaceutical bulletin 56(12), 1691-1697, 2008-12-01
… Two new sempervirol type diterpenes, inumakiols A, B, and six new totarol type diterpenes, inumakiols C-H, were isolated from a methanolic extract of bark of Podocarpus macrophyllus (Podocarpaceae), along with one known abietane, two known totarol type diterpenes, and one known totarol type diterpene dimer. …
NAID 110007004700

Novel abietane diterpenoids and aromatic compounds from Cladonia rangiferina and their antimicrobial activity against antibiotics resistant bacteria

YOSHIKAWA Kazuko,KOKUDO Naoki,TANAKA Masami,NAKANO Tatsuro,SHIBATA Hirofumi,ARAGAKI Naokatsu,HIGUCHI Tomihiko,HASHIMOTO Toshihiro
Chemical & pharmaceutical bulletin 56(1), 89-92, 2008-01-01
… From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). … Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. … Hanagokenol B (2) is also a unique secoabietane diterpene, having γ-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxy-dehydroabietinol. …
NAID 110006531698