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- 1. 成人における過敏性腸症候群の治療 treatment of irritable bowel syndrome in adults
- 2. 成人における慢性便秘のマネージメント management of chronic constipation in adults
- 3. 悪性腫瘍関連胃不全麻痺：病態生理およびマネージメント malignancy associated gastroparesis pathophysiology and management
- 4. 小腸内細菌過剰繁殖の治療 treatment of small intestinal bacterial overgrowth
- 5. 成人における機能性胃腸症 functional dyspepsia in adults
English Journal
- A high-throughput method for predicting drug effects on gut transit time using larval zebrafish.
- Cassar S1, Huang X2, Cole T2.
- Journal of pharmacological and toxicological methods.J Pharmacol Toxicol Methods.2015 Nov-Dec;76:72-5. doi: 10.1016/j.vascn.2015.08.156. Epub 2015 Aug 24.
- INTRODUCTION: Zebrafish are an attractive vertebrate model due to their small size, transparency through organogenesis, and high fecundity. The zebrafish gastrointestinal (GI) tract is similar to the mammalian GI tract in gene expression, nervous system control, and response to chemical challenges.
- PMID 26311656
- Luminal 5-HT stimulates colonic bicarbonate secretion in rats.
- Kaji I1,2, Akiba Y1,2,3, Said H4, Narimatsu K1, Kaunitz JD1,5,2,3.
- British journal of pharmacology.Br J Pharmacol.2015 Oct;172(19):4655-70. doi: 10.1111/bph.13216. Epub 2015 Aug 26.
- BACKGROUND AND PURPOSE: The bioactive monoamine 5-HT, implicated in the pathogenesis of functional gastrointestinal disorders, is abundantly synthesized and stored in rat proximal colonic mucosa and released to the gut lumen and subepithelial space. Despite much data regarding its expression and fun
- PMID 26061462
- Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach.
- Han X1,2,3, Quinney SK2,4,5, Wang Z2,6, Zhang P2, Duke J7, Desta Z3,5, Elmendorf JS8, Flockhart DA3,5, Li L2,3,6,7.
- Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2015 Sep;98(3):321-7. doi: 10.1002/cpt.150.
- Myopathy is a group of muscle diseases that can be induced or exacerbated by drug-drug interactions (DDIs). We sought to identify clinically important myopathic DDIs and elucidate their underlying mechanisms. Five DDIs were found to increase the risk of myopathy based on analysis of observational da
- PMID 25975815
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