同: 結核菌熱水抽出物 hot water extract of Mycobacterium tuberculosis
商: アンサー
関: その他の血液・体液用薬

WordNet

the 26th letter of the Roman alphabet; "the British call Z zed and the Scots call it ezed but Americans call it zee"; "he doesnt know A from izzard" (同)z, zee, zed, ezed, izzard

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/25 20:23:26」(JST)

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1. 黒色腫（メラノーマ）における所属リンパ節の病理学的評価 pathologic evaluation of regional lymph nodes in melanoma
2. Insulin: Drug formulations
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4. 2型糖尿病の治療のためのジペプチジルペプチダーゼ4（DPP-4）阻害剤 dipeptidyl peptidase 4 dpp 4 inhibitors for the treatment of type 2 diabetes mellitus
5. 静脈血栓塞栓症の患者における理論的根拠と無期限の抗凝固の適応 rationale and indications for indefinite anticoagulation in patients with venous thromboembolism

English Journal

Z-100, an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B, prevents spontaneous lymphatic metastasis of B16-BL6 melanoma.

Horii T, Yoshinaga K, Kobayashi N, Seto K, Orikawa Y, Okamoto M, Eta R, Ohira Y, Katsunuma K, Hori Y, Tanaka T, Takei M.Author information Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.AbstractLymphatic metastasis is common in advanced-stage carcinoma and is associated with a poor prognosis. However, few effective treatments to inhibit it are available. Z-100 is an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B that contains polysaccharides such as arabinomannan and mannan. Here, we investigated the inhibitory effect of Z-100 on spontaneous lymphatic metastasis. C57BL/6N mice injected subcutaneously with B16-BL6 melanoma cells in the right hind footpad were administered Z-100 subcutaneously in the right inguinal region on a daily basis. On day twenty-one after the injection, the right inguinal lymph nodes were excised, and the extent of metastasis, the number of immune cells, and the amount of granzyme B protein in the lymph nodes were examined. We also investigated the combined effect of Z-100 and irradiation in this model. Results showed that Z-100 reduced number of animals with metastasis, with respective metastasis rates of 85.7%, 42.9%, 7.1% and 0.0% in saline, 0.1 mg/kg Z-100, 1 mg/kg Z-100 and 10 mg/kg Z-100 group. Further, mice that had been given Z-100 were found to have more immune cells and granzyme B protein in the lymph nodes than control mice. The combination of low dose Z-100 and irradiation also inhibited spontaneous lymph node metastases. These findings suggest that Z-100 may be beneficial in preventing lymphatic metastasis by enhancing the immune response.
Biological & pharmaceutical bulletin.Biol Pharm Bull.2014 Jan 25. [Epub ahead of print]
Lymphatic metastasis is common in advanced-stage carcinoma and is associated with a poor prognosis. However, few effective treatments to inhibit it are available. Z-100 is an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B that contains polysaccharides such as arabinomannan an
PMID 24463609

Characterization of metabolites of GLS4 in humans using ultrahigh-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Zhou X, Li L, Deng P, Chen X, Zhong D.Author information Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, P.R. China.AbstractRATIONALE: GLS4 is a heteroaryldihydropyrimidine compound that inhibits hepatitis B virus (HBV) replication by drug-induced depletion of nucleocapsids. It is currently undergoing clinical trials in China to treat HBV infection. The aim of this study was to identify the metabolites of GLS4 in humans.
Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2013 Nov 15;27(21):2483-92. doi: 10.1002/rcm.6710.
RATIONALE: GLS4 is a heteroaryldihydropyrimidine compound that inhibits hepatitis B virus (HBV) replication by drug-induced depletion of nucleocapsids. It is currently undergoing clinical trials in China to treat HBV infection. The aim of this study was to identify the metabolites of GLS4 in humans.
PMID 24097405

Surface characterisation and bonding of Y-TZP following non-thermal plasma treatment.

Valverde GB, Coelho PG, Janal MN, Lorenzoni FC, Carvalho RM, Thompson VP, Weltemann KD, Silva NR.Author information Piracicaba School of Dentistry-UNICAMP-Brazil, Department of Prosthodontics and Operative Dentistry, Tufts University, School of Dental Medicine, Boston, MA, USA. guigavalverde@yahoo.comAbstractOBJECTIVES: (1) To chemically characterise Y-TZP surface via X-ray photoelectron spectroscopy (XPS) and evaluate the surface energy levels (SE) after non-thermal plasma (NTP). (2) To test the microtensile bond strength (MTBS) of Y-TZP bonded to cured composite disks, after a combination of different surface conditioning methods.
Journal of dentistry.J Dent.2013 Jan;41(1):51-9. doi: 10.1016/j.jdent.2012.10.002. Epub 2012 Oct 5.
OBJECTIVES: (1) To chemically characterise Y-TZP surface via X-ray photoelectron spectroscopy (XPS) and evaluate the surface energy levels (SE) after non-thermal plasma (NTP). (2) To test the microtensile bond strength (MTBS) of Y-TZP bonded to cured composite disks, after a combination of different
PMID 23044388

Japanese Journal

Superheavy Elements : A Probe for Nuclear Matter at the Extremes(YKIS2011 papers,Frontier Issues in Physics of Exotic Nuclei)

ACKERMANN Dieter
Progress of theoretical physics. Supplement (196), 255-262, 2012-10-22
… The spherical shell stabilised superheavy elements (SHE) predicted at the extreme of high Z and A are a nuclear structure phenomenon. …
NAID 110009543681

Neutron one-quasiparticle states in 251Fm151 populated via the α decay of 255No

Asai M.,Tsukada K.,Haba H.,Ishii Y.,Ichikawa T.,Toyoshima A.,Ishii T.,Nagame Y.,Nishinaka I.,Kojima Y.,Sueki K.,末木啓介
Physical Review C 83(1), 014315, 2011-01-00
… It is found that the excitation energy of the 1/2+[620] state in N=151 isotones increases with the atomic number, especially at Z⩾100, while that of the 1/2+[631] state decreases at Z=100. …
NAID 120002836907

Influence of Ion-Ion Coulomb Interactions on FT-ICR Mass Spectra at a High Magnetic Field: A Many-Particle Simulation Using a Special-Purpose Computer

Fujiwara Makoto,Happo Naohisa,Tanaka Koichi
Journal of the Mass Spectrometry Society of Japan 58(5), 169-173, 2010
… At a magnetic field of 5 T, the peak coalescence problem was investigated and at high ion density the peak coalescence appeared for closely spaced m/z ion mixtures of m/z 100.00 and 100.05; … Furthermore, ion loss ratio was estimated for m/z 100.00 ions as a function of initial ion population and it was found that the peak intensity is proportional to the initially trapped ion population at low ion density; …
NAID 130000441932