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the 25th letter of the Roman alphabet (同)y, wye

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yttriumの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/01 18:53:43」(JST)

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Yersinia enterocolitica is a species of gram-negative coccobacillus-shaped bacterium, belonging to the family Enterobacteriaceae. Yersinia enterocolitica infection causes the disease yersiniosis, which is a zoonotic disease occurring in humans as well as a wide array of animals such as cattle, deer, pigs, and birds. Many of these animals recover from the disease and become asymptomatic carriers.^[1] It infects the host by sticking to the cells of the host using Trimeric Autotransporter Adhesins (TAA).

Signs and symptoms

Acute Y. enterocolitica infections usually lead to mild self-limiting entero-colitis or terminal ileitis in humans. Symptoms may include watery or bloody diarrhea and fever. After oral uptake yersiniae replicate in the terminal ileum and invade Peyer's patches. From here yersiniae can disseminate further to mesenteric lymph nodes causing lymphadenopathy. This condition can be confused with appendicitis and is therefore called pseudoappendicitis. In immunosuppressed individuals, yersiniae can disseminate from the gut to liver and spleen and form abscesses. Because Yersinia is a siderophilic (iron-loving) bacteria, people with hereditary hemochromatosis (a disease resulting in high body iron levels) are more susceptible to infection with Yersinia (and other siderophilic bacteria). In fact, the most common contaminant of stored blood is Y. enterocolitica.^[2] See yersiniosis for further details. Yersiniae are usually transmitted to humans by insufficiently cooked pork or contaminated water.

Treatment

Yersiniosis is usually self-limiting and does not require treatment. Severe infections (septicemia, focal infection, immunosuppression) can be treated with doxycycline in combination with an aminoglycoside. Other antibiotics that are active against Y. enterocolitica include trimethoprim-sulfamethoxasole, fluoroquinolones, ceftriaxone, and chloramphenicol. Y. enterocolitica is usually resistant to penicillin G, ampicillin, and cephalotin due to beta-lactamase production.^[3]

Prognosis

Y. enterocolitica infections are sometimes followed by chronic inflammatory diseases such as arthritis.^[4]

Y. enterocolitica seems to be associated with autoimmune Graves-Basedow thyroiditis.^[5] Whilst indirect evidence exists, direct causative evidence is limited,^[6] and Y. enterocolitica is probably not a major cause of this disease, but may contribute to the development of thyroid autoimmunity arising for other reasons in genetically susceptible individuals.^[7] It has also been suggested that Y. enterocolitica infection is not the cause of auto-immune thyroid disease, but rather is only an associated condition; with both having a shared inherited susceptibility.^[8] More recently the role for Y. enterocolitica has been disputed.^[9]

References

^ Collins FM (1996). Pasteurella, and Francisella. In: Barron's Medical Microbiology (Barron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. (via NCBI Bookshelf).
^ Goljan, Edward F. Rapid Review Pathology. Second Edition. Page 279, Table 15-1.
^ Bottone, Edward (April 1997). "Yersinia enterocolitica: the charisma continues". Clinical Microbiology Reviews (American Society for Microbiology) 10 (2): 257–276. PMC 172919. PMID 9105754. //www.ncbi.nlm.nih.gov/pmc/articles/PMC172919/.
^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
^ Benvenga S, Santarpia L, Trimarchi F, Guarneri F (2006). "Human Thyroid Autoantigens and Proteins of Yersinia and Borrelia Share Amino Acid Sequence Homology That Includes Binding Motifs to HLA-DR Molecules and T-Cell Receptor". Thyroid 16 (3): 225–236. doi:10.1089/thy.2006.16.225. PMID 16571084.
^ Tomer Y, Davies T (1993). "Infection, thyroid disease, and autoimmunity" (PDF). Endocr Rev 14 (1): 107–20. doi:10.1210/er.14.1.107. PMID 8491150. http://edrv.endojournals.org/cgi/reprint/14/1/107.pdf.
^ Toivanen P, Toivanen A (1994). "Does Yersinia induce autoimmunity?". Int Arch Allergy Immunol 104 (2): 107–11. doi:10.1159/000236717. PMID 8199453.
^ Strieder T, Wenzel B, Prummel M, Tijssen J, Wiersinga W (2003). "Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease". Clin Exp Immunol 132 (2): 278–82. doi:10.1046/j.1365-2249.2003.02139.x. PMC 1808711. PMID 12699417. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1808711/.
^ Hansen P, Wenzel B, Brix T, Hegedüs L (2006). "Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study". Clin Exp Immunol 146 (1): 32–8. doi:10.1111/j.1365-2249.2006.03183.x. PMC 1809723. PMID 16968395. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1809723/.

External links

Wikispecies has information related to: Yersinia enterocolitica

Yersinia enterocolitica genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. エルシニア感染症の臨床症状および診断 clinical manifestations and diagnosis of yersinia infections
2. 腸炎エルシニアおよび偽結核菌感染症の治療および予防 treatment and prevention of yersinia enterocolitica and yersinia pseudotuberculosis infection
3. エルシニア症の疫学 epidemiology of yersiniosis
4. エルシニア感染の微生物学および病因 microbiology and pathogenesis of yersinia infections
5. 小児における食中毒 food poisoning in children

Japanese Journal

Erythema nodosum associated with Yersinia enterocolitica infection

YOTSU Rie,MII Sumiyuki,HAYASHI Rika,HARADA Harumi,FURUKAWA Keiichi,ETO Hikaru
Journal of dermatology 37(9), 819-822, 2010-09-01
NAID 10027067299

Related Pictures

★リンクテーブル★

リンク元	「エンテロコリチカ菌」「エルシニア・エンテロコリチカ」
関連記事	「Y」

「エンテロコリチカ菌」

Yersinia enterocolitica
	Classification and external resources
ICD-10	A04.6, A04.6
ICD-9	008.44
DiseasesDB	14218
eMedicine	article/970186
MeSH	D015009

Yersinia enterocolitica
	Yersinia enterocolitica colonies growing on XLD agar plates.
Scientific classification
Kingdom:	Bacteria
Phylum:	Proteobacteria
Class:	Gamma Proteobacteria
Order:	Enterobacteriales
Family:	Enterobacteriaceae
Genus:	Yersinia
Species:	Y. enterocolitica
Binomial name
	Yersinia enterocolitica; (Schleifstein & Coleman 1939)

　　[★]

ラ: Yersinia enterocolitica、Y. enterocolitica
関: エルシニア・エンテロコリティカ、エルシニア・エンテロコリチカ

「エルシニア・エンテロコリチカ」

　　[★]

ラ: Yersinia enterocolitica、Y. enterocolitica
関: エンテロコリチカ菌、エルシニア・エンテロコリティカ

「Y」

　　[★]

[Barron-1] Collins FM (1996). Pasteurella, and Francisella. In: Barron's Medical Microbiology (Barron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. (via NCBI Bookshelf).

[2] Goljan, Edward F. Rapid Review Pathology. Second Edition. Page 279, Table 15-1.

[3] Bottone, Edward (April 1997). "Yersinia enterocolitica: the charisma continues". Clinical Microbiology Reviews (American Society for Microbiology) 10 (2): 257–276. PMC 172919. PMID 9105754. //www.ncbi.nlm.nih.gov/pmc/articles/PMC172919/.

[Sherris-4] Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.

[Benvenga_2006-5] Benvenga S, Santarpia L, Trimarchi F, Guarneri F (2006). "Human Thyroid Autoantigens and Proteins of Yersinia and Borrelia Share Amino Acid Sequence Homology That Includes Binding Motifs to HLA-DR Molecules and T-Cell Receptor". Thyroid 16 (3): 225–236. doi:10.1089/thy.2006.16.225. PMID 16571084.

[EndocrReview1993-6] Tomer Y, Davies T (1993). "Infection, thyroid disease, and autoimmunity" (PDF). Endocr Rev 14 (1): 107–20. doi:10.1210/er.14.1.107. PMID 8491150. http://edrv.endojournals.org/cgi/reprint/14/1/107.pdf.

[7] Toivanen P, Toivanen A (1994). "Does Yersinia induce autoimmunity?". Int Arch Allergy Immunol 104 (2): 107–11. doi:10.1159/000236717. PMID 8199453.

[8] Strieder T, Wenzel B, Prummel M, Tijssen J, Wiersinga W (2003). "Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease". Clin Exp Immunol 132 (2): 278–82. doi:10.1046/j.1365-2249.2003.02139.x. PMC 1808711. PMID 12699417. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1808711/.

[9] Hansen P, Wenzel B, Brix T, Hegedüs L (2006). "Yersinia enterocolitica infection does not confer an increased risk of thyroid antibodies: evidence from a Danish twin study". Clin Exp Immunol 146 (1): 32–8. doi:10.1111/j.1365-2249.2006.03183.x. PMC 1809723. PMID 16968395. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1809723/.

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案内

Y. enterocolitica