同: WT1

WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
informal term for information; "give me the gen on your new line of computers"

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1. 先天性乳児ネフローゼ症候群 congenital and infantile nephrotic syndrome
2. ウィルムス腫瘍の症状、診断、および病期分類 presentation diagnosis and staging of wilms tumor
3. 小児におけるネフローゼ症候群の病因、臨床症状、および診断 etiology clinical manifestations and diagnosis of nephrotic syndrome in children
4. 外陰部異常を有する幼児の評価 evaluation of the infant with ambiguous genitalia
5. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia

English Journal

PAX Immunoreactivity Patterns in Anaplastic Wilms Tumors.

Fan R.Author information Department of Pathology, Indiana University, Indianapolis, IN, USA.AbstractThis immunohistochemistry study explores particular differential immuno expression patterns of PAX genes in unfavorable histology Wilms tumor (UH) and favorable histology Wilms tumor (FH). Some unique features in unfavorable histology Wilms tumor were discovered and they may provide insightful clues of this unique and both clinically and biologically important phenomenon.
Fetal and pediatric pathology.Fetal Pediatr Pathol.2014 Feb;33(1):60-3. doi: 10.3109/15513815.2013.856499. Epub 2013 Nov 18.
This immunohistochemistry study explores particular differential immuno expression patterns of PAX genes in unfavorable histology Wilms tumor (UH) and favorable histology Wilms tumor (FH). Some unique features in unfavorable histology Wilms tumor were discovered and they may provide insightful clues
PMID 24245795

Aberrant activation, nuclear localization, and phosphorylation of yes-associated protein-1 in the embryonic kidney and Wilms tumor.

Murphy AJ, Pierce J, de Caestecker C, Libes J, Neblett D, de Caestecker M, Perantoni AO, Tanigawa S, Anderson JR, Dome JS, Das A, Carroll TJ, Lovvorn HN 3rd.Author information Department of Pediatric Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.AbstractBACKGROUND: The Yes-associated-protein-1 (YAP1) is a novel, direct regulator of stem cell genes both in development and cancer. FAT4 is an upstream regulator that induces YAP1 cytosolic sequestering by phosphorylation (p-Ser 127) and therefore inhibits YAP1-dependent cellular proliferation. We hypothesized that loss of FAT4 signaling would result in expansion of the nephron progenitor population in kidney development and that YAP1 subcellular localization would be dysregulated in Wilms tumor (WT), an embryonal malignancy that retains gene expression profiles and histologic features reminiscent of the embryonic kidney.
Pediatric blood & cancer.Pediatr Blood Cancer.2014 Feb;61(2):198-205. doi: 10.1002/pbc.24788. Epub 2013 Sep 20.
BACKGROUND: The Yes-associated-protein-1 (YAP1) is a novel, direct regulator of stem cell genes both in development and cancer. FAT4 is an upstream regulator that induces YAP1 cytosolic sequestering by phosphorylation (p-Ser 127) and therefore inhibits YAP1-dependent cellular proliferation. We hypot
PMID 24115727

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.

Ping XL1, Sun BF2, Wang L3, Xiao W1, Yang X2, Wang WJ2, Adhikari S2, Shi Y2, Lv Y2, Chen YS2, Zhao X2, Li A2, Yang Y2, Dahal U2, Lou XM4, Liu X5, Huang J6, Yuan WP7, Zhu XF7, Cheng T7, Zhao YL2, Wang X5, Danielsen JM8, Liu F3, Yang YG1.Author information 11] Center For Genome Variations and Precision Bio-Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China.2Center For Genome Variations and Precision Bio-Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.3State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.4Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.5Center for Structural Biology, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.6Life Sciences Institute, Zhejiang University, Zhejiang 310058, China.7State Key Laboratory of Experimental Hematology, Institute of Hematology, Tianjin 300041, China.81] Center For Genome Variations and Precision Bio-Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [2] The Novo Nordisk Foundation Center for Protein Research, Ubiquitin Signalling Group, Faculty of Health Sciences, Copenhagen, Denmark.AbstractThe methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the nature of this complex remains largely unknown. Here we report two new components of the human m6A methyltransferase complex, Wilms' tumor 1-associating protein (WTAP) and methyltransferase like 14 (METTL14). WTAP interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for catalytic activity of the m6A methyltransferase in vivo. The majority of RNAs bound by WTAP and METTL3 in vivo represent mRNAs containing the consensus m6A motif. In the absence of WTAP, the RNA-binding capability of METTL3 is strongly reduced, suggesting that WTAP may function to regulate recruitment of the m6A methyltransferase complex to mRNA targets. Furthermore, transcriptomic analyses in combination with photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) illustrate that WTAP and METTL3 regulate expression and alternative splicing of genes involved in transcription and RNA processing. Morpholino-mediated knockdown targeting WTAP and/or METTL3 in zebrafish embryos caused tissue differentiation defects and increased apoptosis. These findings provide strong evidence that WTAP may function as a regulatory subunit in the m6A methyltransferase complex and play a critical role in epitranscriptomic regulation of RNA metabolism.Cell Research advance online publication 10 January 2014; doi:10.1038/cr.2014.3.
Cell research.Cell Res.2014 Jan 10. doi: 10.1038/cr.2014.3. [Epub ahead of print]
The methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the nature of this complex remains largely unknown. Here we report two new components of the human m6A methyltransferase complex, Wi
PMID 24407421

Japanese Journal

症例報告臍帯血移植後再発に対してアザシチジン投与が有効であった骨髄異形成症候群

上田里美,宮腰重三郎,遅塚明貴 [他]
臨床血液 54(12), 2177-2181, 2013-12
NAID 40019933711

ペプチドワクチン療法の現状と将来 (特集変貌するがん免疫療法)

杉山治夫
腫瘍内科 12(2), 112-121, 2013-08
NAID 40019798663

Immunohistochemical Characterization of a Renal Nephroblastoma in a Trp53-mutant and Prolyl Isomerase 1-deficient Mouse

Castiglioni Vittoria,De Maglie Marcella,Queliti Roberta,Rustighi Alessandra,Del Sal Giannino,Radaelli Enrico
Journal of Toxicologic Pathology 26(4), 423-427, 2013
… A nephroblastoma is a tumor arising from metanephric blastema occurring in childhood. … The present work describes a nephroblastoma in a young mouse homozygous for the specific Trp53 R172H point mutation coupled with targeted deletion of the Pin1 gene. … The affected kidney was effaced by a biphasic tumor with an epithelial component arranged in tubules surrounded by nests of blastemal cells. …
NAID 130003382458