同: WNE

WordNet

to, toward, or in the west; "we moved west to Arizona"; "situated west of Boston"
the cardinal compass point that is a 270 degrees (同)due west, westward, W
the direction corresponding to the westward cardinal compass point
a location in the western part of a country, region, or city
situated in or facing or moving toward the west
English painter (born in America) who became the second president of the Royal Academy (1738-1820) (同)Benjamin West
United States film actress (1892-1980) (同)Mae_West
British writer (born in Ireland) (1892-1983) (同)Rebecca West, Dame Rebecca West, Cicily Isabel Fairfield
the countries of (originally) Europe and (now including) North America and South America (同)Occident
the region of the United States lying to the west of the Mississippi River (同)western United States
the worlds longest river (4150 miles); flows northward through eastern Africa into the Mediterranean; the Nile River valley in Egypt was the site of the worlds first great civilization (同)Nile River
inflammation of the brain usually caused by a virus; symptoms include headache and neck pain and drowsiness and nausea and fever (`phrenitis is no longer in scientific use) (同)cephalitis, phrenitis

PrepTutorEJDIC

《the west》『西』;(…の)西方,(…の)西部《+of+名》 / 《the West》『西洋』西欧,欧米 / 《the West》《米》西部地方 / 《the West》(共産圏に対して)西側[諸国],西側陣営 / 『西の』,西部の,西向きの;西からの / 『西へ』,西に;西方に
ナイル川(アフリカ東部ビクトリア湖に発し地中海に駐ぐ大河)
脳炎
nickelの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/16 15:24:39」(JST)

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West Nile virus (WNV) is a mosquito-borne zoonotic arbovirus belonging to the genus Flavivirus in the family Flaviviridae. It is found in temperate and tropical regions of the world. It was first identified in the West Nile subregion in the East African nation of Uganda in 1937. Prior to the mid-1990s, WNV disease occurred only sporadically and was considered a minor risk for humans, until an outbreak in Algeria in 1994, with cases of WNV-caused encephalitis, and the first large outbreak in Romania in 1996, with a high number of cases with neuroinvasive disease. WNV has now spread globally, with the first case in the Western Hemisphere being identified in New York City in 1999;^[1] over the next five years, the virus spread across the continental United States, north into Canada, and southward into the Caribbean islands and Latin America. WNV also spread to Europe, beyond the Mediterranean Basin, and a new strain of the virus was identified in Italy in 2012.^[2] WNV is occurs on an ongoing basis in Africa, Asia, Australia, the Middle East, Europe, Canada^[3] and in the United States. In 2012 the US experienced one of its worst epidemics in which 286 people died, with the state of Texas being hard hit by this virus,^[4]^[5]

The main mode of WNV transmission is via various species of mosquitoes, which are the prime vector, with birds being the most commonly infected animal and serving as the prime reservoir host—especially passerines, which are of the largest order of birds, Passeriformes. WNV has been found in various species of ticks, but current research suggests they are not important vectors of the virus. WNV also infects various mammal species, including humans, and has been identified in reptilian species, including alligators and crocodiles, and also in amphibians. Not all animal species that are susceptible to WNV infection, including humans, and not all bird species develop sufficient viral levels to transmit the disease to uninfected mosquitoes, and are thus not considered major factors in WNV transmission.^[6]^[7]

Approximately 80% of West Nile virus infections in humans are subclinical, which cause no symptoms.^[8] In the cases where symptoms do occur—termed West Nile fever in cases without neurological disease—the time from infection to the appearance of symptoms (incubation period) is typically between 2 and 15 days. Symptoms may include fever, headaches, fatigue, muscle pain or aches (myalgias), malaise, nausea, anorexia, vomiting, and rash. Less than 1% of the cases are severe and result in neurological disease when the central nervous system is affected. People of advanced age, the very young, or those with immunosuppression, either medically induced, such as those taking immunosupressive drugs, or due to a pre-existing medical condition such as HIV infection, are most susceptible. The specific neurological diseases that may occur are West Nile encephalitis, which causes inflammation of the brain, West Nile meningitis, which causes inflammation of the meninges, which are the protective membranes that cover the brain and spinal cord, West Nile meningoencephalitis, which causes inflammation of the brain and also the meninges surrounding it, and West Nile poliomyelitis—spinal cord inflammation, which results in a syndrome similar to polio, which may cause acute flaccid paralysis.

Currently, no vaccine against WNV infection is available. The best method to reduce the rates of WNV infection is mosquito control on the part of municipalities, businesses and individual citizens to reduce breeding populations of mosquitoes in public, commercial and private areas via various means including eliminating standing pools of water where mosquitoes breed, such as in old tires, buckets, and unused swimming pools. On an individual basis, the use of personal protective measures to avoid being bitten by an infected mosquito, via the use of mosquito repellent, window screens, avoiding areas where mosquitoes are more prone to congregate, such as near marshes, and areas with heavy vegetation, and being more vigilant from dusk to dawn when mosquitoes are most active offers the best defense. In the event of being bitten by an infected mosquito, familiarity of the symptoms of WNV on the part of laypersons, physicians and allied health professions affords the best chance of receiving timely medical treatment, which may aid in reducing associated possible complications and also appropriate palliative care.

Signs and symptoms

The incubation period for WNV—the amount of time from infection to symptom onset—is typically from between 2 and 15 days. Headache can be a prominent symptom of WNV fever, meningitis, encephalitis, meningoencephalitis, and it may or may not be present in poliomyelitis-like syndrome. Thus, headache is not a useful indicator of neuroinvasive disease.

West Nile fever (WNF), which occurs in 20 percent of cases, is a febrile syndrome that causes flu-like symptoms.^[9] Most characterizations of WNF generally describe it as a mild, acute syndrome lasting 3 to 6 days after symptom onset. Systematic follow-up studies of patients with WNF have not been done, so this information is largely anecdotal. In addition to a high fever, headache, chills, excessive sweating, weakness, fatigue, swollen lymph nodes, drowsiness, pain in the joints and flu-like symptoms. Gastrointestinal symptoms that may occur include nausea, vomiting, loss of appetite, and diarrhea. Fewer than one-third of patients develop a rash.

West Nile neuroinvasive disease (WNND), which occurs in less than 1 percent of cases, is when the virus infects the central nervous system resulting in meningitis, encephalitis, meningoencephalitis or a poliomyelitis-like syndrome.^[10] Many patients with WNND have normal neuroimaging studies, although abnormalities may be present in various cerebral areas including the basal ganglia, thalamus, cerebellum, and brainstem.^[10]

West Nile virus encephalitis (WNE) is the most common neuroinvasive manifestation of WNND. WNE presents with similar symptoms to other viral encephalitis with fever, headaches, and altered mental status. A prominent finding in WNE is muscular weakness (30 to 50 percent of patients with encephalitis), often with lower motor neuron symptoms, flaccid paralysis, and hyporeflexia with no sensory abnormalities.^[11]^[12]

West Nile meningitis (WNM) usually involves fever, headache, and stiff neck. Pleocytosis, an increase of white blood cells in cerebrospinal fluid, is also present. Changes in consciousness are not usually seen and are mild when present.

West Nile meningoencephalitis is inflammation of both the brain (encephalitis) and meninges (meningitis).

West Nile poliomyelitis (WNP), an acute flaccid paralysis syndrome associated with WNV infection, is less common than WNM or WNE. This syndrome is generally characterized by the acute onset of asymmetric limb weakness or paralysis in the absence of sensory loss. Pain sometimes precedes the paralysis. The paralysis can occur in the absence of fever, headache, or other common symptoms associated with WNV infection. Involvement of respiratory muscles, leading to acute respiratory failure, can sometimes occur.

West-Nile reversible paralysis,. Like WNP, the weakness or paralysis is asymmetric.^[13] Reported cases have been noted to have an initial preservation of deep tendon reflexes, which is not expected for a pure anterior horn involvement.^[13] Disconnect of upper motor neuron influences on the anterior horn cells possibly by myelitis or glutamate excitotoxicity have been suggested as mechanisms.^[13] The prognosis for recovery is excellent.

Nonneurologic complications of WNV infection that may rarely occur include fulminant hepatitis, pancreatitis,^[14] myocarditis, rhabdomyolysis,^[15] orchitis,^[16] nephritis, optic neuritis^[17] and cardiac dysrhythmias and hemorrhagic fever with coagulopathy.^[18] Chorioretinitis may also be more common than previously thought.^[19]

Cutaneous manifestations specifically rashes, are not uncommon in WNV-infected patients; however, there is a paucity of detailed descriptions in case reports and there are few clinical images widely available. Punctate erythematous, macular, and papular eruptions, most pronounced on the extremities have been observed in WNV cases and in some cases histopathologic findings have shown a sparse superficial perivascular lymphocytic infiltrate, a manifestation commonly seen in viral exanthems. A literature review provides support that this punctate rash is a common cutaneous presentation of WNV infection.^[20]

Virology

West Nile virus life cycle. After binding and uptake, the virion envelope fuses with cellular membranes, followed by uncoating of the nucleocapsid and release of the RNA genome into the cytoplasm. The viral genome serves as messenger RNA (mRNA) for translation of all viral proteins and as template during RNA replication. Copies are subsequently packaged within new virus particles that are transported in vesicles to the cell membrane.

WNV is one of the Japanese encephalitis antigenic serocomplex of viruses. Image reconstructions and cryoelectron microscopy reveal a 45–50 nm virion covered with a relatively smooth protein surface. This structure is similar to the dengue fever virus; both belong to the genus Flavivirus within the family Flaviviridae. The genetic material of WNV is a positive-sense, single strand of RNA, which is between 11,000 and 12,000 nucleotides long; these genes encode seven nonstructural proteins and three structural proteins. The RNA strand is held within a nucleocapsid formed from 12-kDa protein blocks; the capsid is contained within a host-derived membrane altered by two viral glycoproteins.

Phylogeny

Phylogenetic tree of West Nile viruses based on sequencing of the envelope gene during complete genome sequencing of the virus^[21]

Studies of phylogenetic lineages determined WNV emerged as a distinct virus around 1000 years ago.^[22] This initial virus developed into two distinct lineages, lineage 1 and its multiple profiles is the source of the epidemic transmission in Africa and throughout the world. Lineage 2 was considered an Africa zoonosis. However, in 2008, lineage 2, previously only seen in horses in sub-Saharan Africa and Madagascar, began to appear in horses in Europe, where the first known outbreak affected 18 animals in Hungary in 2008.^[23] Lineage 1 West Nile virus was detected in South Africa in 2010 in a mare and her aborted fetus; previously, only lineage 2 West Nile virus had been detected in horses and humans in South Africa.^[24] A 2007 fatal case in a killer whale in Texas broadened the known host range of West Nile virus to include cetaceans.^[25]

The United States virus was very closely related to a lineage 1 strain found in Israel in 1998. Since the first North American cases in 1999, the virus has been reported throughout the United States, Canada, Mexico, the Caribbean, and Central America. There have been human cases and equine cases, and many birds are infected. The Barbary macaque, Macaca sylvanus, was the first nonhuman primate to contract WNV.^[26] Both the United States and Israeli strains are marked by high mortality rates in infected avian populations; the presence of dead birds—especially Corvidae—can be an early indicator of the arrival of the virus.

Transmission

West Nile virus maintains itself in nature by cycling between mosquitoes in the genus Culex and certain species of birds. A mosquito (the vector) bites an uninfected bird (the host), the virus amplifies within the bird, an uninfected mosquito bites the bird and is in turn infected. Other species such as humans and horses are incidental infections, because the virus does not amplify well within these species and they are considered dead-end hosts.

West Nile virus (WNV) is transmitted through female mosquitoes, which are the prime vectors of the virus. Only females feed on blood, and different species take a blood meal's from different types of vertebrate hosts. The important mosquito vectors vary according to geographical area; in the United States, Culex pipiens (Eastern United States, and urban and residential areas of the United States north of 36-39°N), Culex tarsalis (Midwest and West), and Culex quinquefasciatus (Southeast) are the main vector species.^[27]

The mosquito species that are most frequently infected with WNV feed primarily on birds.^[28] Mosquitoes show further selectivity, exhibiting preference for different species of birds. In the United States, WNV mosquito vectors feed on members of the Corvidae and thrush family more often that would be expected from their abundance,.^[29] Among the preferred species within these families are the American crow, a corvid, and the American robin (Turdus migratorius), a thrush.^[29]

The proboscis of a female mosquito—here a southern house mosquito (Culex quinquefasciatus)—pierces the epidermis and dermis to allow it to feed on human blood from a capillary: this one is almost fully tumescent. The mosquito injects saliva, which contains an anesthetic, and an anticoagulant into the puncture wound, and in infected mosquitoes, West Nile virus.

Some species of birds develop sufficient viral levels (>~10^4.2 log PFU/ml;^[30]) after being infected to transmit the infection to biting mosquitoes that in turn go on to infect other birds. In birds that die from WNV, death usually occurs 4–6 days.^[31] In mammals, and several species of birds the virus does not multiply as readily (i.e., does not develop high viremia during infection), and mosquitoes biting infected these hosts are not believed to ingest sufficient virus to become infected, making them so-called dead-end hosts.^[30] As a result of the differential infectiousness of hosts, the feeding patterns of mosquitoes play an important role in WNV transmission,^[28]^[29] and they are partly genetically controlled, even within a species.

Direct human-to-human transmission initially was believed to be caused only by occupational exposure, such as in a laboratory setting,^[32] or conjunctive exposure to infected blood.^[33] The US outbreak identified additional transmission methods through blood transfusion,^[34] organ transplant,^[35] intrauterine exposure,^[36] and breast feeding.^[37] Since 2003, blood banks in the United States routinely screen for the virus among their donors.^[38] As a precautionary measure, the UK's National Blood Service initially ran a test for this disease in donors who donate within 28 days of a visit to the United States, Canada, or the northeastern provinces of Italy, and the Scottish National Blood Transfusion Service^[39] asks prospective donors to wait 28 days after returning from North America or the northeastern provinces of Italy before donating.

Recently, the potential for mosquito saliva to affect the course of WNV disease was demonstrated.^[40]^[41]^[42] Mosquitoes inoculate their saliva into the skin while obtaining blood. Mosquito saliva is a pharmacological cocktail of secreted molecules, principally proteins, that can affect vascular constriction, blood coagulation, platelet aggregation, inflammation, and immunity. It clearly alters the immune response in a manner that may be advantageous to a virus.^[43]^[44]^[45]^[46] Studies have shown it can specifically modulate the immune response during early virus infection,^[47] and mosquito feeding can exacerbate WNV infection, leading to higher viremia and more severe forms of disease.^[40]^[41]^[42]

Vertical transmission

Vertical transmission, the transmission of a viral or bacterial disease from the female of the species to her offspring, has been observed in various West Nile virus studies, amongst different species of mosquitoes in both the laboratory and in nature.^[48] Mosquito progeny infected vertically in autumn, may potentially serve as a mechanism for WNV to overwinter and initiate enzootic horizontal transmission the following spring, although it likely plays little role in transmission in the summer and fall.^[49]

Risk factors

Risk factors independently associated with developing a clinical infection with WNV include a suppressed immune system and a patient history of organ transplantation.^[50] For neuroinvasive disease the additional risk factors include older age (>50+), male sex, hypertension, and diabetes mellitus.^[51]^[52]

A genetic factor also appears to increase susceptibility to West Nile disease. A mutation of the gene CCR5 gives some protection against HIV but leads to more serious complications of WNV infection. Carriers of two mutated copies of CCR5 made up 4.0 to 4.5% of a sample of West Nile disease sufferers, while the incidence of the gene in the general population is only 1.0%.^[53]^[54]

Diagnosis

An immunoglobulin M antibody molecule: Definitive diagnosis of WNV is obtained through detection of virus-specific IgM and neutralizing antibodies.

Preliminary diagnosis is often based on the patient's clinical symptoms, places and dates of travel (if patient is from a nonendemic country or area), activities, and epidemiologic history of the location where infection occurred. A recent history of mosquito bites and an acute febrile illness associated with neurologic signs and symptoms should cause clinical suspicion of WNV.

Diagnosis of West Nile virus infections is generally accomplished by serologic testing of blood serum or cerebrospinal fluid (CSF), which is obtained via a lumbar puncture. Typical findings of WNV infection include lymphocytic pleocytosis, elevated protein level, reference glucose and lactic acid levels, and no erythrocytes.

Definitive diagnosis of WNV is obtained through detection of virus-specific antibody IgM and neutralizing antibodies. Cases of West Nile virus meningitis and encephalitis that have been serologically confirmed produce similar degrees of CSF pleocytosis and are often associated with substantial CSF neutrophilia.^[55] Specimens collected within eight days following onset of illness may not test positive for West Nile IgM, and testing should be repeated. A positive test for West Nile IgG in the absence of a positive West Nile IgM is indicative of a previous flavavirus infection and is not by itself evidence of an acute West Nile virus infection.^[56]

If cases of suspected West Nile virus infection, sera should be collected on both the acute and convalescent phases of the illness. Convalescent specimens should be collected 2–3 weeks after acute specimens.

It is common in serologic testing for cross-reactions to occur among flaviviruses such as dengue virus (DENV) and tick-borne encephalitis virus; this necessitates caution when evaluating serologic results of flaviviral infections.^[57]

Four FDA-cleared WNV IgM ELISA kits are commercially available from different manufacturers in the U.S., each of these kits is indicated for use on serum to aid in the presumptive laboratory diagnosis of WNV infection in patients with clinical symptoms of meningitis or encephalitis. Positive WNV test kits obtained via use of these kits should be confirmed by additional testing at a state health department laboratory or CDC.

In fatal cases, nucleic acid amplification, histopathology with immunohistochemistry, and virus culture of autopsy tissues can also be useful. Only a few state laboratories or other specialized laboratories, including those at CDC, are capable of doing this specialized testing.

Differential diagnosis

A number of various diseases may present with symptoms similar to those caused by a clinical West Nile virus infection. Those causing neuroinvasive disease symptoms include the enterovirus infection and bacterial meningitis. Accounting for differential diagnoses is a crucial step in the definitive diagnosis of WNV infection. Consideration of a differential diagnosis is required when a patient presents with unexplained febrile illness, extreme headache, encephalitis or meningitis. Diagnostic and serologic laboratory testing using polymerase chain reaction (PCR) testing and viral culture of CSF to identify the specific pathogen causing the symptoms, is the only currently available means of differentiating between causes of encephalitis and meningitis.

Prevention

Low-cost, ceiling hung mosquito netting for a bed

Personal protective measures can be taken to greatly reduce the risk of being bitten by an infected mosquito:

Using insect repellent on exposed skin to repel mosquitoes. EPA-registered repellents include products containing DEET (N,N-diethylmetatoluamide) and picaridin (KBR 3023). DEET concentrations of 30% to 50% are effective for several hours. Picaridin, available at 7% and 15% concentrations, needs more frequent application. DEET formulations as high as 50% are recommended for both adults and children over two months of age. Protect infants less than two months of age by using a carrier draped with mosquito netting with an elastic edge for a tight fit.
When using sunscreen, apply sunscreen first and then repellent. Repellent should be washed off at the end of the day before going to bed.
Wear long-sleeve shirts, which should be tucked in, long pants, socks, and hats to cover exposed skin. Insect repellents should be applied over top of protective clothing for greater protection. Do not apply insect repellents underneath clothing.
The application of permethrin-containing (e.g., Permanone) or other insect repellents to clothing, shoes, tents, mosquito nets, and other gear for greater protection. Permethrin is not labeled for use directly on skin. Most repellent is generally removed from clothing and gear by a single washing, but permethrin-treated clothing is effective for up to five washings.
Be aware that most mosquitoes that transmit disease are most active during twilight periods (dawn and dusk or in the evening). A notable exception is the Asian tiger mosquito, which is a daytime feeder and is more apt to be found in, or on the periphery of, shaded areas with heavy vegetation. They are now widespread in the United States, and in Florida they have been found in all 67 counties.^[58]
Staying in air-conditioned or well-screened housing, and/or sleeping under an insecticide-treated bed net. Bed nets should be tucked under mattresses and can be sprayed with a repellent if not already treated with an insecticide.

Monitoring and control

West Nile virus can be sampled from the environment by the pooling of trapped mosquitoes via ovitraps, carbon dioxide-baited light traps, and gravid traps, testing blood samples drawn from wild birds, dogs, and sentinel monkeys, as well as testing brains of dead birds found by various animal control agencies and the public.

Testing of the mosquito samples requires the use of reverse-transcriptase PCR (RT-PCR) to directly amplify and show the presence of virus in the submitted samples. When using the blood sera of wild birds and sentinel chickens, samples must be tested for the presence of WNV antibodies by use of immunohistochemistry (IHC)^[59] or enzyme-linked immunosorbent assay (ELISA).^[60]

Dead birds, after necropsy, or their oral swab samples collected on specific RNA-preserving filter paper card,^[61]^[62] can have their virus presence tested by either RT-PCR or IHC, where virus shows up as brown-stained tissue because of a substrate-enzyme reaction.

West Nile control is achieved through mosquito control, by elimination of mosquito breeding sites such as abandoned pools, applying larvacide to active breeding areas, and targeting the adult population via lethal ovitraps and aerial spraying of pesticides.

Environmentalists have condemned attempts to control the transmitting mosquitoes by spraying pesticide, saying the detrimental health effects of spraying outweigh the relatively few lives that may be saved, and more environmentally friendly ways of controlling mosquitoes are available. They also question the effectiveness of insecticide spraying, as they believe mosquitoes that are resting or flying above the level of spraying will not be killed; the most common vector in the northeastern United States, Culex pipiens, is a canopy feeder.

A carbon dioxide-baited CDC light trap at NPSmonitoring site: The highest individual light trap total for 2010 was from a trap located in a salt marsh in the Fire Island National Seashore: around 25,142 mosquitoes were collected during a 16-hour period on August 31.^[63]
Eggs of permanent water mosquitoes can hatch, and the larvae survive, in only a few ounces of water. Less than half the amount that may collect in a discarded coffee cup. Floodwater species lay their eggs on wet soil or other moist surfaces. Hatch time is variable for both types; under favorable circumstances, i.e. warm weather, the eggs of some species may hatch in as few as 1–3 days after being laid.^[64]
Used tires often hold stagnant water and are a breeding ground for many species of mosquitoes. Some species such as the Asian tiger mosquito prefer manmade containers, such as tires, in which to lay their eggs. The rapid spread of this aggressive daytime feeding species beyond their native range has been attributed to the used tire trade.^[58]^[65]

Treatment

No specific treatment is available for WNV infection. In severe cases treatment consists of supportive care that often involves hospitalization, intravenous fluids, respiratory support, and prevention of secondary infections.

Prognosis

While the general prognosis is favorable, current studies indicate that West Nile Fever can often be more severe than previously recognized, with studies of various recent outbreaks indicating that it may take as long as 60–90 days to recover.^[12]^[66] People with milder WNF are just as likely as those with more severe manifestations of neuroinvasive disease to experience multiple long term (>1+ years) somatic complaints such as tremor, and dysfunction in motor skills and executive functions. People with milder illness are just as likely as people with more severe illness to experience adverse outcomes.^[67] Recovery is marked by a long convalescence with fatigue. One study found that neuroinvasive WNV infection was associated with an increased risk for subsequent kidney disease.^[68]^[69]

Epidemiology

Global distribution of West Nile virus (2006)

WNV was first isolated from a feverish 37-year-old woman at Omogo in the West Nile District of Uganda in 1937 during research on yellow fever virus.^[70] A series of serosurveys in 1939 in central Africa found anti-WNV positive results ranging from 1.4% (Congo) to 46.4% (White Nile region, Sudan). It was subsequently identified in Egypt (1942) and India (1953), a 1950 serosurvey in Egypt found 90% of those over 40 years in age had WNV antibodies. The ecology was characterized in 1953 with studies in Egypt^[71] and Israel.^[72] The virus became recognized as a cause of severe human meningoencephalitis in elderly patients during an outbreak in Israel in 1957. The disease was first noted in horses in Egypt and France in the early 1960s and found to be widespread in southern Europe, southwest Asia and Australia.

The first appearance of WNV in the Western Hemisphere was in 1999^[1] with encephalitis reported in humans, dogs, cats, and horses, and the subsequent spread in the United States may be an important milestone in the evolving history of this virus. The American outbreak began in College Point, Queens in New York City and was later spread to the neighboring states of New Jersey and Connecticut. The virus is believed to have entered in an infected bird or mosquito, although there is no clear evidence.^[73] West Nile virus is now endemic in Africa, Europe, the Middle East, west and central Asia, Oceania (subtype Kunjin), and most recently, North America and is spreading into Central and South America.

Recent outbreaks of West Nile virus encephalitis in humans have occurred in Algeria (1994), Romania (1996 to 1997), the Czech Republic (1997), Congo (1998), Russia (1999), the United States (1999 to 2009), Canada (1999–2007), Israel (2000) and Greece (2010).

Epizootics of disease in horses occurred in Morocco (1996), Italy (1998), the United States (1999 to 2001), and France (2000), Mexico (2003) and Sardinia (2011).

Outdoor workers (including biological fieldworkers, construction workers, farmers, landscapers, and painters), healthcare personnel, and laboratory personnel who perform necropsies on animals are at risk of contracting WNV.^[74]

Research

A vaccine for horses (ATCvet code: QI05AA10) based on killed viruses exists; some zoos have given this vaccine to their birds, although its effectiveness is unknown. Dogs and cats show few if any signs of infection. There have been no known cases of direct canine-human or feline-human transmission; although these pets can become infected, it is unlikely they are, in turn, capable of infecting native mosquitoes and thus continuing the disease cycle.^[75] AMD3100, which had been proposed as an antiretroviral drug for HIV, has shown promise against West Nile encephalitis. Morpholino antisense oligos conjugated to cell penetrating peptides have been shown to partially protect mice from WNV disease.^[76] There have also been attempts to treat infections using ribavirin, intravenous immunoglobulin, or alpha interferon.^[77] GenoMed, a U.S. biotech company, has found that blocking angiotensin II can treat the "cytokine storm" of West Nile virus encephalitis as well as other viruses.^[78]

A vaccine called Chimerivax-WNV is being actively researched and has undergone phase II Clinical trials in 2011.^[79]^[80]

References

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^ Klenk, K.; Snow, J.; Morgan, K.; Bowen, R.; Stephens, M.; Foster, F.; Gordy, P.; Beckett, S.; Komar, N.; Gubler, D.; Bunning, M. (2004). "Alligators as West Nile Virus Amplifiers". Emerging Infectious Diseases 10 (12): 2150–2155. doi:10.3201/eid1012.040264. PMC 3323409. PMID 15663852.
^ "West Nile Virus: What You Need to Know CDC Fact Sheet". www.CDC.gov. Retrieved 2012-04-09.
^ Olejnik E (1952). "Infectious adenitis transmitted by Culex molestus". Bull Res Counc Isr 2: 210–1.
^ ^a ^b Davis LE, DeBiasi R, Goade DE, et al. (Sep 2006). "West Nile virus neuroinvasive disease". Ann Neurol 60 (3): 286–300. doi:10.1002/ana.20959. PMID 16983682.
^ Flores Anticona EM, Zainah H, Ouellette DR, Johnson LE (2012). "Two case reports of neuroinvasive west nile virus infection in the critical care unit". Case Rep Infect Dis 2012: 839458. doi:10.1155/2012/839458. PMC 3433121. PMID 22966470.
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^ ^a ^b ^c Mojumder, D. K., Agosto, M., Wilms, H.; et al. (March 2014). "Is initial preservation of deep tendon reflexes in West Nile Virus paralysis a good prognostic sign?". Neurology Asia 19 (1): 93–97.
^ Asnis DS, Conetta R, Teixeira AA, Waldman G, Sampson BA (March 2000). "The West Nile Virus outbreak of 1999 in New York: the Flushing Hospital experience". Clin. Infect. Dis. 30 (3): 413–8. doi:10.1086/313737. PMID 10722421.
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External links

	Medicine portal
	Viruses portal

De Filette M, Ulbert S, Diamond M, Sanders NN (2012). "Recent progress in West Nile virus diagnosis and vaccination". Vet. Res. 43 (1): 16. doi:10.1186/1297-9716-43-16. PMC 3311072. PMID 22380523.
"West Nile Virus". Division of Vector-Borne Diseases, U.S. Centers for Disease Control and Prevention (CDC).
CDC—West Nile Virus—NIOSH Workplace Safety and Health Topic
Recommendations for Protecting Laboratory, Field, and Clinical Workers from West Nile Virus Exposure
West Nile Virus Resource Guide—National Pesticide Information Center
Vaccine Research Center (VRC)—Information concerning WNV vaccine research studies
Nature news article on West Nile paralysis
CBC News Coverage of West Nile in Canada
Gene mutation turned West Nile virus into killer disease among crows
Virus Pathogen Database and Analysis Resource (ViPR): Flaviviridae
Species Profile- West Nile Virus (Flavivirus), National Invasive Species Information Center, United States National Agricultural Library. Lists general information and resources for West Nile Virus.
3D macromolecular structures of the West Nile Virus archived in the EM Data Bank(EMDB)
West Nile Virus—West Nile Encephalitis Brain Scans

UpToDate Contents

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1. ウエストナイルウイルス感染症の臨床症状と診断clinical manifestations and diagnosis of west nile virus infection [show details]
…considered to have WN virus antibodies if neutralizing antibody titers to WN virus are at least fourfold greater than those for other tested flaviviruses: A positive PRNT for WN virus in combination with …
2. ウエストナイルウイルス感染の治療および予防treatment and prevention of west nile virus infection [show details]
…unexplained fever in an area of ongoing WN virus transmission should have serum tested for antibody to WN virus. If laboratory tests indicate recent infection with WN virus, the infection should be reported …
3. ウエストナイルウイルス感染の疫学および病因epidemiology and pathogenesis of west nile virus infection [show details]
…countries related to the spread of WN virus lineage 2 strains . Since 2000, the ArboNET national surveillance system has tracked WN virus in the United States, and WN virus is the leading cause of domestically …
4. St. Louis encephalitisst louis encephalitis [show details]
…have significantly diminished over the last decade, apparently due to interference by West Nile virus . West Nile virus, which was introduced into the United States in 1999, is strongly cross-protective against …
5. 小児の急性ウイルス性脳炎：発症機序、罹患率、病因acute viral encephalitis in children pathogenesis incidence and etiology [show details]
… West Nile virus – West Nile virus (WNV), mainly transmitted by mosquito bites, is found across the United States. WNV CNS disease occurs in <1 percent of infected persons, mainly adults . WNV encephalitis…

English Journal

A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available.

Ishikawa T1, Yamanaka A2, Konishi E3.Author information 1Department of Microbiology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan. Electronic address: toishika@dokkyomed.ac.jp.2BIKEN Endowed Department of Dengue Vaccine Development, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand; BIKEN Endowed Department of Dengue Vaccine Development, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: knmya@biken.osaka-u.ac.jp.3BIKEN Endowed Department of Dengue Vaccine Development, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand; BIKEN Endowed Department of Dengue Vaccine Development, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: ekon@biken.osaka-u.ac.jp.AbstractGenus flavivirus comprises many important human pathogens causing public health problems worldwide. Some flavivirus infections are characterized by a relatively high mortality rate and/or high sequelae rate in survivors. Because most flavivirus life cycles are maintained between arthropod vectors and amplifying/reservoir hosts in the absence of humans, eradication of flaviviruses might be extremely difficult. Flavivirus vaccine development is considered a reasonable method to prevent flavivirus infections. Some vaccines have been successfully developed, but others have not, regardless of much effort. This review article describes currently available flavivirus vaccines against yellow fever, Japanese encephalitis, and tick-borne encephalitis. In addition, the current status of dengue and West Nile virus vaccine development is reviewed and problems regarding their development are discussed.
Vaccine.Vaccine.2014 Mar 10;32(12):1326-1337. doi: 10.1016/j.vaccine.2014.01.040. Epub 2014 Jan 29.
Genus flavivirus comprises many important human pathogens causing public health problems worldwide. Some flavivirus infections are characterized by a relatively high mortality rate and/or high sequelae rate in survivors. Because most flavivirus life cycles are maintained between arthropod vectors an
PMID 24486372

B cell response and mechanisms of antibody protection to west nile virus.

Austin SK1, Dowd KA2.Author information 1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. skaustin@DOM.wustl.edu.2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. dowdka@mail.nih.gov.AbstractWest Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approved vaccines or WNV-specific therapies for the treatment of WNV disease in humans. From studies with small animal models and convalescent human patients, a great deal has been learned concerning the immune response to infection with WNV. Here, we provide an overview of a subset of that information regarding the humoral and antibody response generated during WNV infection.
Viruses.Viruses.2014 Mar 3;6(3):1015-36. doi: 10.3390/v6031015.
West Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approve
PMID 24594676

Initial and long-term costs of patients hospitalized with west nile virus disease.

Staples JE1, Shankar MB, Sejvar JJ, Meltzer MI, Fischer M.Author information 1Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; Prion and Health Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Preparedness and Emerging Infections, Centers for Disease Control and Prevention, Atlanta, Georgia.AbstractAbstract. There are no published data on the economic burden for specific West Nile virus (WNV) clinical syndromes (i.e., fever, meningitis, encephalitis, and acute flaccid paralysis [AFP]). We estimated initial hospital and lost-productivity costs from 80 patients hospitalized with WNV disease in Colorado during 2003; 38 of these patients were followed for 5 years to determine long-term medical and lost-productivity costs. Initial costs were highest for patients with AFP (median $25,117; range $5,385-$283,381) and encephalitis (median $20,105; range $3,965-$324,167). Long-term costs were highest for patients with AFP (median $22,628; range $624-$439,945) and meningitis (median $10,556; range $0-$260,748). Extrapolating from this small cohort to national surveillance data, we estimated the total cumulative costs of reported WNV hospitalized cases from 1999 through 2012 to be $778 million (95% confidence interval $673 million-$1.01 billion). These estimates can be used in assessing the cost-effectiveness of interventions to prevent WNV disease.
The American journal of tropical medicine and hygiene.Am J Trop Med Hyg.2014 Mar;90(3):402-9. doi: 10.4269/ajtmh.13-0206. Epub 2014 Feb 10.
Abstract. There are no published data on the economic burden for specific West Nile virus (WNV) clinical syndromes (i.e., fever, meningitis, encephalitis, and acute flaccid paralysis [AFP]). We estimated initial hospital and lost-productivity costs from 80 patients hospitalized with WNV disease in C
PMID 24515937

Japanese Journal

Tick-borne flaviviruses alter membrane structure and replicate in dendrites of primary mouse neuronal cultures

Journal of General Virology 95(4), 849-861, 2014-04
NAID 120005575002

フラビウイルスのリバースジェネティクス

ウイルス 63(1), 13-22, 2013-06-01
NAID 10031187699

The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile Virus

Japanese Journal of Veterinary Research 60(2), 95-103, 2012-08
NAID 120004689053

「西ナイル脳炎」

West Nile Virus
Virus classification
Group:	Group IV ((+)ssRNA)
Order:	Unassigned
Family:	Flaviviridae
Genus:	Flavivirus
Species:	West Nile virus

West Nile fever
Classification and external resources
Specialty	Infectious disease
ICD-10	A92.3
ICD-9-CM	066.4
DiseasesDB	30025
MedlinePlus	007186
Patient UK	West Nile virus
MeSH	D014901

　　[★]

英: West Nile encephalitis
関: ウエストナイル脳炎

「WNE」

　　[★]

同: West Nile encephalitis

「west」

　　[★]

西

関: western

「Ni」

　　[★] ニッケル nickel 　

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[3] Chen, Chen C.; Jenkins, Emily; Epp, Tasha; Waldner, Cheryl; Curry, Philip S.; Soos, Catherine (2013-07-22). "Climate Change and West Nile Virus in a Highly Endemic Region of North America". International Journal of Environmental Research and Public Health 10 (7): 3052–3071. doi:10.3390/ijerph10073052. PMC 3734476. PMID 23880729.

[pmid24210089-4] Murray KO, Ruktanonchai D, Hesalroad D, Fonken E, Nolan MS (November 2013). "West Nile virus, Texas, USA, 2012". Emerging Infectious Diseases 19 (11): 1836–8. doi:10.3201/eid1911.130768. PMC 3837649. PMID 24210089. Retrieved 2014-12-08.

[5] Fox, M. (May 13, 2013). "2012 was deadliest year for West Nile in US, CDC says". NBC News. Retrieved May 13, 2013.

[Steinman_2003-6] Steinman, A.; Banet-Noach, C.; Tal, S.; Levi, O.; Simanov, L.; Perk, S.; Malkinson, M.; Shpigel, N. (2003). "West Nile Virus Infection in Crocodiles". Emerging Infectious Diseases 9 (7): 887–889. doi:10.3201/eid0907.020816. PMC 3023443. PMID 12899140.

[Klenk_2004-7] Klenk, K.; Snow, J.; Morgan, K.; Bowen, R.; Stephens, M.; Foster, F.; Gordy, P.; Beckett, S.; Komar, N.; Gubler, D.; Bunning, M. (2004). "Alligators as West Nile Virus Amplifiers". Emerging Infectious Diseases 10 (12): 2150–2155. doi:10.3201/eid1012.040264. PMC 3323409. PMID 15663852.

[8] "West Nile Virus: What You Need to Know CDC Fact Sheet". www.CDC.gov. Retrieved 2012-04-09.

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West Nile encephalitis