ワッセルマン反応、Wassermann反応

WordNet

(mechanics) the equal and opposite force that is produced when any force is applied to a body; "every action has an equal and opposite reaction"
a response that reveals a persons feelings or attitude; "he was pleased by the audiences reaction to his performance"; "John feared his mothers reaction when she saw the broken lamp"
a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age" (同)response
doing something in opposition to another way of doing it that you dont like; "his style of painting was a reaction against cubism"
an idea evoked by some experience; "his reaction to the news was to start planning what to do"
extreme conservatism in political or social matters; "the forces of reaction carried the election"
German bacteriologist who developed a diagnostic test for syphilis (1866-1925) (同)August von Wassermann

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{名}(…に対する)『反応』《+『to』+『名』》 / 〈U〉(…に対する)(政治的・社会的な)『反動』,逆コース《+『against』+『名』》 / 〈U〉〈C〉化学反応,化学変化 / 〈U〉〈C〉(物理学で)反作用

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/20 18:36:13」(JST)

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The Wassermann test or Wassermann reaction (WR)^[1] is an antibody test for syphilis, named after the bacteriologist August Paul von Wassermann, based on complement-fixation.

Method

A sample of blood or cerebrospinal fluid is taken and introduced to the antigen - cardiolipin extracted from bovine muscle or heart. Syphilis non-specific antibodies (reagin, see RPR) react with the lipid - the Wassermann reaction of antiphospholipid antibodies (APAs). The intensity of the reaction (1, 2, 3, or 4) indicates the severity of the condition.

Uncertainty

The reaction is not specific to syphilis and will produce a positive reaction to other diseases, including malaria, tuberculosis, and numerous other diseases. It is possible for an infected individual to produce no reaction and for a successfully treated individual to continue to produce a reaction (known as being "Wassermann fast" or "fixed").

Development and refinement

The antibody test was developed by Wassermann, Julius Citron, and Albert Neisser at the Robert Koch Institute for Infectious Diseases in 1906.^[2]^[3] The test was a growth from the work of Bordet and Gengou on complementing-fixation reaction, published in 1901, and the positive reaction is sometimes called the Bordet-Gengou-Wassermann reaction or Bordet-Wassermann reaction.

The Wassermann test has been refined - the Kahn test,^[4] and the Kolmer test^{[citation needed]} - and it is rarely used today. Replacement tests such as the VDRL test and the RPR test, initially based on flocculation techniques (Hinton), have been shown to produce far fewer false positive results^{[citation needed]}. Indeed the "biologic false positives" of modern tests usually indicate a serious alternate condition, often an autoimmune disease.

References

^ Beck, A. (2009). "The role of the spirochaete in the Wassermann reaction". Journal of Hygiene 39 (03): 298. DOI:10.1017/S0022172400011943. edit
^ doctor/2511 at Who Named It?
^ A Wassermann, A. Neisser and C. Bruck. Eine serodiagnostische Reaktion bei Syphilis. Deutsche medicinische Wochenschrift, Berlin, 1906, 32: 745-746. Announcing the test for syphilis.
^ Gilbert R (January 1930). "Standardization of the Wassermann Test : Abstract of Progress Test". Am J Public Health Nations Health 20 (1): 47–8. DOI:10.2105/AJPH.20.1.47. PMC 1555718. PMID 18012919. http://www.ajph.org/cgi/pmidlookup?view=long&pmid=18012919.

Citron, Dr. Julius, "Immunity" (English translation) 1914 163-164

External links

Wassermann+reaction at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Early treatment with fluconazole may abrogate the development of IgG antibodies in coccidioidomycosis.

Thompson GR 3rd, Lunetta JM, Johnson SM, Taylor S, Bays D, Cohen SH, Pappagianis D.SourceDepartment of Medical Microbiology and Immunology, Coccidioidomycosis Serology Laboratory, University of California, Davis, Davis, California.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2011 Sep;53(6):e20-4.
Background.?We have observed a number of patients who fail to develop coccidioidal complement fixing (CF) antibody (immunoglobulin [IgG]) after the initiation of early antifungal therapy. Although this is the first description of this phenomenon in mycology, a precedent for the abrogation of the i
PMID 21865185

Evaluation of the Determine Syphilis TP assay for the detection of antibodies against Treponema pallidum for the serodiagnosis of syphilis.

Zhuang YH, Tian Y, Chen Y, Tang J, Wang JQ, Li P, Li Q, Jiang YQ.SourceDepartment of Clinical Laboratory Medicine, Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yi Shan Rd., Shanghai, 200233, People's Republic of China.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.Eur J Clin Microbiol Infect Dis.2011 Aug 25. [Epub ahead of print]
Currently, infectious syphilis has been resurgent in China and has become a significant public health problem. The rapid expansion of syphilis screening programs is urgently required. In the present study, the performance of the Determine Syphilis TP assay (Determine TP assay) for the detection of a
PMID 21866323

Japanese Journal

Immunological study on cardiolipin from Escherichia coli

Kanemasa Yasuhiro
Acta Medicinae Okayama 22(5), 1968-10
… coli cardiolipin a study was made on its reactivityto Wassermann antibody reagin by OGATA'S box titration, and the following results were obtained. … In the reaction made to take place with the serum from rabbitimmunized with beef heart cardiolipin, E. …
NAID 120002312096

北洋サケ・マス漁労の労働医学的研究 : 第1報 A丸に関する調査

高桑栄松,方波見雅夫,斉藤和雄,川村繁市,池田弘,土門洋哉,安栄鉄男,大中吉人,三浦祐晶
産業医学 10(8), 433-437, 1968-08-20
… It was an indication of the level of their knowledge about the prevention of veneral diseases that 23% of the crew were positive in the Wassermann reaction. …
NAID 110003754661