VWF

出典: meddic

フォンウィルブランド因子, von Willebrand因子, von Willebrand factor

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/06/12 15:25:53」(JST)

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英文文献

  • Biocompatibility of silk-tropoelastin protein polymers.
  • Liu H1, Wise SG2, Rnjak-Kovacina J3, Kaplan DL4, Bilek MM5, Weiss AS6, Fei J7, Bao S8.Author information 1Discipline of Pathology and School of Medical Science, University of Sydney, NSW 2006, Australia; Bosch Institute, University of Sydney, NSW 2006, Australia.2The Heart Research Institute, Sydney, NSW 2042, Australia; School of Molecular Bioscience, University of Sydney, NSW 2006, Australia.3Department of Biomedical Engineering, Tufts University, Medford, MA, USA; Graduate School of Biomedical Engineering, University of New South Wales, NSW 2051, Australia.4Department of Biomedical Engineering, Tufts University, Medford, MA, USA.5School of Physics, University of Sydney, NSW 2006, Australia.6School of Molecular Bioscience, University of Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, NSW 2006, Australia; Bosch Institute, University of Sydney, NSW 2006, Australia.7School of Life Science and Technology, Shanghai Tongji University, China; Research Centre for Model Organisms, Shanghai, China. Electronic address: jfei@tongji.edu.cn.8Discipline of Pathology and School of Medical Science, University of Sydney, NSW 2006, Australia; Bosch Institute, University of Sydney, NSW 2006, Australia. Electronic address: bob.bao@sydney.edu.auor.AbstractBlended polymers are used extensively in many critical medical conditions as components of permanently implanted devices. Hybrid protein polymers containing recombinant human tropoelastin and silk fibroin have favorable characteristics as implantable scaffolds in terms of mechanical and biological properties. A firefly luciferase transgenic mouse model was used to monitor real-time IL-1β production localized to the site of biomaterial implantation, to observe the acute immune response (up to 5 days) to these materials. Significantly reduced levels of IL-1β were observed in silk/tropoelastin implants compared to control silk only implants at 1, 2 and 3 days post-surgery. Subsequently, mice (n = 9) were euthanized at 10 days (10D) and 3 weeks (3W) post-surgery to assess inflammatory cell infiltration and collagen deposition, using histopathology and immunohistochemistry. Compared to control silk only implants, fewer total inflammatory cells were found in silk/tropoelastin (∼29% at 10D and ∼47% at 3W). Also fewer ingrowth cells (∼42% at 10D and ∼63% at 3W) were observed within the silk/tropoelastin implants compared to silk only. Lower IL-6 (∼52%) and MMP-2 (∼84%) (pro-inflammatory) were also detected for silk/tropoelastin at 10 days. After 3 weeks implantation, reduced neovascularization (vWF ∼43%), fewer proliferating cells (Ki67 ∼58% and PCNA ∼41%), macrophages (F4/80 ∼64%), lower IL-10 (∼47%) and MMP-9 (∼55%) were also observed in silk/tropoelastin materials compared to silk only. Together, these results suggest that incorporation of tropoelastin improves on the established biocompatibility of silk fibroin, uniquely measured here as a reduced foreign body inflammatory response.
  • Biomaterials.Biomaterials.2014 Jun;35(19):5138-47. doi: 10.1016/j.biomaterials.2014.03.024. Epub 2014 Apr 2.
  • Blended polymers are used extensively in many critical medical conditions as components of permanently implanted devices. Hybrid protein polymers containing recombinant human tropoelastin and silk fibroin have favorable characteristics as implantable scaffolds in terms of mechanical and biological p
  • PMID 24702962
  • Proliferation of ASC-derived endothelial cells in a 3D electrospun mesh: Impact of bone-biomimetic nanocomposite and co-culture with ASC-derived osteoblasts.
  • Gao S1, Calcagni M2, Welti M2, Hemmi S1, Hild N3, Stark WJ3, Meier Bürgisser G2, Wanner GA1, Cinelli P1, Buschmann J4.Author information 1Division of Trauma Surgery, University Hospital Zurich, ZKF, Sternwartstrasse 14, CH-8091 Zurich, Switzerland.2Division of Plastic and Hand Surgery, University Hospital Zurich, ZKF, Sternwartstrasse 14, CH-8091 Zurich, Switzerland.3Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.4Division of Plastic and Hand Surgery, University Hospital Zurich, ZKF, Sternwartstrasse 14, CH-8091 Zurich, Switzerland. Electronic address: johanna.buschmann@usz.ch.AbstractBACKGROUND: Fractures with a critical size bone defect are associated with high rates of delayed- and non-union. The treatment of such complications remains a serious issue in orthopaedic surgery. Adipose derived stem cells (ASCs) combined with biomimetic materials can potentially be used to increase fracture healing. Nevertheless, a number of requirements have to be fulfilled; in particular, the insufficient vascularisation of the bone constructs. Here, the objectives were to study the impact of ASC-derived osteoblasts on ASC-derived endothelial cells in a 3D co-culture and the effect of 40wt% of amorphous calcium phosphate nanoparticles on the proliferation and differentiation of ASC-derived endothelial cells when present in PLGA.
  • Injury.Injury.2014 Jun;45(6):974-80. doi: 10.1016/j.injury.2014.02.035. Epub 2014 Mar 12.
  • BACKGROUND: Fractures with a critical size bone defect are associated with high rates of delayed- and non-union. The treatment of such complications remains a serious issue in orthopaedic surgery. Adipose derived stem cells (ASCs) combined with biomimetic materials can potentially be used to increas
  • PMID 24650943
  • Evaluation of an automated method for measuring von Willebrand factor activity in clinical samples without ristocetin.
  • Graf L1, Moffat KA, Carlino SA, Chan AK, Iorio A, Giulivi A, Hayward CP.Author information 1Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.AbstractINTRODUCTION: The development of an automated, von Willebrand factor (VWF) activity assay, Innovance(®) VWF Ac (VWF:Ac), which measures VWF binding to the platelet receptor glycoprotein Ibα without ristocetin, led us to evaluate the assay for diagnosing von Willebrand disease (VWD) and monitoring therapy.
  • International journal of laboratory hematology.Int J Lab Hematol.2014 Jun;36(3):341-51. doi: 10.1111/ijlh.12218.
  • INTRODUCTION: The development of an automated, von Willebrand factor (VWF) activity assay, Innovance(®) VWF Ac (VWF:Ac), which measures VWF binding to the platelet receptor glycoprotein Ibα without ristocetin, led us to evaluate the assay for diagnosing von Willebrand disease (VWD) and monitoring
  • PMID 24750681

和文文献

  • フォン・ヴィレブランド因子(VWF)とフォン・ヴィレブランド病(VWD) (特集 血管内皮細胞関連因子)
  • 20719 VWF分子のアンフォルディングにおける血小板粘着力発生
  • 日本機械学会関東支部総会講演会講演論文集 2015(21), "20719-1"-"20719-2", 2015-03-20
  • NAID 110009948371
  • 医学と医療の最前線 TTP(血栓性血小板減少性紫斑病)の病態と治療

関連リンク

フォンヴィレブランド因子活性(リストセチンコファクター), vWf ( von Willebrand factor ) 測定方法 : 固定血小板凝集法 外注会社 : SRL 基準範囲 : 60~170 % 臨床的意義 フォン・ヴィレブランド因子(von Willebrand ...
また、α顆粒が存在し、フィブリノゲン、vWF 、凝固第V因子、血小板第4因子、血小板由来成長因子(PDGF)、fibronectin、α 1-antitrypsin、β-トロンボグロブリン(β-thromboglobulin:β-TG )、P-セレクチン、トロンボスポンジン 2+ ...

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★リンクテーブル★
先読みvon Willebrand factor」「von Willebrand因子
リンク元フォンウィルブランド因子
関連記事V」「vWF

von Willebrand factor」

  [★] フォンウィルブランド因子


von Willebrand因子」

  [★] フォンウィルブランド因子


フォンウィルブランド因子」

  [★]

von Willebrand factor (BPT), vWF, VWF
フォンビルブラント因子フォンウィルブランド因子von Willebrand因子vW因子
血液凝固因子


概念

構造

  • ジスルフィド結合によりマルチマーを形成しており、分子量は500~20,000kDa以上に分布している。

産生組織

存在部位

  • 血漿中にあり循環。血漿、血小板、α顆粒、内皮下組織などに存在(SAN.236)

半減期

  • 24時間

機能

  • コラーゲンと血小板を結合させる
  • 血管内皮細胞が脱落しその下の細胞外マトリクスが露出されると、血漿中のフォンウィルブランド因子が細胞マトリックスに結合し、これを足場に血小板のGpIb/GpIX複合体を介して血小板が結合する

臨床関連

  • フォンウィルブランド因子の機能異常

vWFのレセプター異常


V」

  [★]

WordNet   license wordnet

「the 22nd letter of the Roman alphabet」
v

PrepTutorEJDIC   license prepejdic

「vanadium の化学記号」


vWF」

  [★] フォンウィルブランド因子


"http://meddic.jp/VWF" より作成


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