English Journal

Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading.

Egashira Y1, Takase M1, Watanabe S2, Ishida J3, Fukamizu A3, Kaneko R4, Yanagawa Y4, Takamori S5.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 Sep 20;113(38):10702-7. doi: 10.1073/pnas.1604527113. Epub 2016 Sep 6.
GABA acts as the major inhibitory neurotransmitter in the mammalian brain, shaping neuronal and circuit activity. For sustained synaptic transmission, synaptic vesicles (SVs) are required to be recycled and refilled with neurotransmitters using an H(+) electrochemical gradient. However, neither the
PMID 27601664

Colocalization of synapse marker proteins evaluated by STED-microscopy reveals patterns of neuronal synapse distribution in vitro.

Dzyubenko E1, Rozenberg A2, Hermann DM3, Faissner A4.
Journal of neuroscience methods.J Neurosci Methods.2016 Sep 9;273:149-159. doi: 10.1016/j.jneumeth.2016.09.001. [Epub ahead of print]
BACKGROUND: Quantification of synapses and their morphological analysis are extensively used in network development and connectivity studies, drug screening and other areas of neuroscience. Thus, a number of quantitative approaches were introduced so far. However, most of the available methods are h
PMID 27615741

GPR30 disrupts the balance of GABAergic and glutamatergic transmission in the spinal cord driving to the development of bone cancer pain.

Luo J1, Huang X2, Li Y1, Li Y1, Xu X1, Gao Y1, Shi R1, Yao W1, Liu J1, Ke C1.
Oncotarget.Oncotarget.2016 Sep 6. doi: 10.18632/oncotarget.11867. [Epub ahead of print]
Cancer induced bone pain is a very complicated clinical pain states that has proven difficult to be treated effectively due to poorly understand of underlying mechanism, but bone cancer pain (BCP) seems to be enhanced by a state of spinal sensitization. In the present study, we showed that carcinoma
PMID 27608844

Japanese Journal

The effect of topiramate on GABA_B receptor, vesicular GABA transporter and paired-pulse inhibition in the gerbil hippocampus

KIM Duk-Soo,KWAK Sung-Eun,KIM Ji-Eun,WON Moo-Ho,CHOI Hui-Chul,SONG Hong-Ki,KIM Yeong-In,CHOI Soo-Young,KANG Tae-Cheon
Neuroscience research : the official journal of the Japan Neuroscience Society 53(4), 413-420, 2005-12-01
NAID 10017131444

TAKAYAMA Chitoshi,INOUE Yoshiro
Neuroscience research : the official journal of the Japan Neuroscience Society 50(4), 447-458, 2004-12-01
… To reveal the distribution of GABA and its secretion mechanisms during brain development, we investigated the immunohistochemical localization of two molecules, GABA and vesicular GABA transporter (VGAT), which is a GABAergic vesicle protein, in the developing mouse cerebellum by means of newly developed antibodies. … Until postnatal day 7 (P7), GABA was localized throughout the GABAergic neurons, and VGAT accumulated at axon varicosities and growth cones, where the α1 subunit did not accumulate. …
NAID 10023901923