小胞結合膜タンパク質1

関: synaptobrevin 1、VAMP-1、vesicle-associated membrane protein 1

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/27 16:16:19」(JST)

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Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.^[1]^[2]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

File:NicotineDopaminergic_WP1602.png

Nicotine Activity on Dopaminergic Neurons edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

^ Archer BT 3rd, Ozcelik T, Jahn R, Francke U, Sudhof TC (Nov 1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". J Biol Chem 265 (28): 17267–73. PMID 1976629.
^ ^a ^b "Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)".

English Journal

TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion.

Meng J1,2, Wang J1, Steinhoff M2, Dolly JO1.
Scientific reports.Sci Rep.2016 Feb 18;6:21226. doi: 10.1038/srep21226.
Transient receptor potential (TRP) A1 and V1 channels relay sensory signals, yet little is known about their transport to the plasmalemma during inflammation. Herein, TRPA1 and TRPV1 were found on vesicles containing calcitonin gene-related peptide (CGRP), accumulated at sites of exo- and endo-cytos
PMID 26888187

SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond.

Cupertino RB1, Kappel DB1, Bandeira CE1, Schuch JB1, da Silva BS1, Müller D1, Bau CH2, Mota NR1.
Journal of neural transmission (Vienna, Austria : 1996).J Neural Transm (Vienna).2016 Feb 8. [Epub ahead of print]
Multiple biological processes throughout development require intracellular vesicular trafficking, where the SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors) complex plays a major role. The core proteins forming the SNARE complex are SNAP-25 (synaptosomal-as
PMID 26856328

Erratum to: Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility.

Sevlever D1, Zou F1,2, Ma L1, Carrasquillo S1, Crump MG1, Culley OJ1, Hunter TA1, Bisceglio GD1, Younkin L1, Allen M1, Carrasquillo MM1, Sando SB3,4, Aasly JO4, Dickson DW1, Graff-Radford NR5, Petersen RC6, Deák F1,7; Kevin Morgan for ARUK consortium, Belbin O8,9.
Molecular neurodegeneration.Mol Neurodegener.2015 Sep 23;10:49. doi: 10.1186/s13024-015-0047-2.
Following publication of this work, we noticed that we inadvertently failed to include Dr Ferenc Deák in the author list. The author list has now been corrected and the amended authors' contributions section has been modified accordingly below.
PMID 26399695

Japanese Journal

An insertion of intracisternal A-particle retrotransposon in a novel member of the phosphoglycerate mutase family in the lew allele of mutant mice

Genes & genetic systems 84(5), 327-334, 2009-10-25
NAID 10026091458

Related Pictures

★リンクテーブル★

リンク元	「synaptobrevin 1」「小胞結合膜タンパク質1」「vesicle-associated membrane protein 1」

「synaptobrevin 1」

Vesicle-associated membrane protein 1 (synaptobrevin 1)
	PDB rendering based on 1kil.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1kil, 1n7s
Identifiers
Symbols	VAMP1 ; SPAX1; SYB1; VAMP-1
External IDs	OMIM: 185880 MGI: 1313276 HomoloGene: 40678 ChEMBL: 2038 GeneCards: VAMP1 Gene
Gene ontology
Molecular function	• SNARE binding; • SNAP receptor activity; • protein binding;
Cellular component	• mitochondrial outer membrane; • cytosol; • integral component of plasma membrane; • synaptic vesicle; • cell surface; • cell junction; • synaptic vesicle membrane; • SNARE complex; • azurophil granule membrane; • specific granule membrane; • terminal bouton; • tertiary granule membrane;
Biological process	• exocytosis; • vesicle fusion; • synaptic transmission; • SNARE complex assembly;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;