WordNet
- a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
- (virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
- a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
PrepTutorEJDIC
- ビールス,ろ過性病原体
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/10 20:09:28」(JST)
wiki en
| Orthomyxoviridae | |
|---|---|
| Electron micrograph of Bourbon virus (scale bar: 100 nm) |
|
| Virus classification | |
| Group: | Group V ((-)ssRNA) |
| Order: | Unassigned |
| Family: | Orthomyxoviridae |
| Genus: | Thogotovirus |
| Type species | |
| Thogoto virus |
|
| Species | |
|
Araguari virus |
|
Thogotovirus is a genus of enveloped RNA viruses, one of six genera in the virus family Orthomyxoviridae. Their single-stranded, negative-sense RNA genome has six or seven segments. Thogotoviruses are distinguished from most other orthomyxoviruses[2] by being arboviruses – viruses that are transmitted by arthropods, in this case usually ticks. Thogotoviruses can replicate in both tick cells and vertebrate cells; one subtype has also been isolated from mosquitoes. A consequence of being transmitted by blood-sucking vectors is that the virus must spread systemically in the vertebrate host – unlike influenza viruses, which are transmitted by respiratory droplets and are usually confined to the respiratory system.[3]
Thogoto virus (THOV) is the type species; the genus also contains the species Dhori virus (DHOV) and its subtype Batken virus, as well as the species or strains Araguari virus, Aransas Bay virus (ABV), Bourbon virus, Jos virus (JOSV) and Upolu virus (UPOV), which have yet to be confirmed by the International Committee on Taxonomy of Viruses (ICTV). A wide range of mammals are infected by members of the genus; some types also infect birds. THOV causes disease in livestock. THOV, DHOV and Bourbon virus can infect humans, and have occasionally been associated with human disease.
Contents
- 1 History
- 2 Virology
- 2.1 Viral proteins
- 2.2 Life cycle
- 3 Epidemiology
- 4 Host interaction and disease
- 4.1 Ticks
- 4.2 Vertebrates
- 5 Treatment and prevention
- 6 Species and strains
- 6.1 THOV-like viruses
- 6.1.1 Thogoto virus (THOV)
- 6.1.2 Araguari virus
- 6.1.3 Aransas Bay virus (ABV)
- 6.1.4 Jos virus (JOSV)
- 6.1.5 Upolu virus (UPOV)
- 6.2 DHOV-like viruses
- 6.2.1 Dhori virus (DHOV)
- 6.2.2 Batken virus
- 6.2.3 Bourbon virus
- 6.1 THOV-like viruses
- 7 Notes and references
- 8 External links
History
THOV and DHOV were identified in the early 1960s in Kenya and India, respectively.[4][5] Two cases of human disease associated with THOV occurred in 1966, and a Russian laboratory accident in the 1980s showed that DHOV can also cause disease in humans.[6][7] The two viruses were originally considered to be bunyaviruses, but characterisation in the 1980s and early 1990s revealed similarities with influenza viruses.[8][9] A genus of "Thogoto-like viruses" within Orthomyxoviridae was proposed in 1995, and recognised by the ICTV under the name Thogotovirus the following year.[10][11] The name comes from Thogoto Forest in Kenya, where THOV was first discovered.[12] Since then, sequence analysis of five viruses discovered in the 1960–70s but unclassified or tentatively assigned to Bunyaviridae led to their being proposed as additional members of the genus.[1][8][13][14] A further proposed member of the genus was characterised by next-generation sequencing in 2014.[6]
Virology
Predicted structure of THOV glycoprotein (left) compared with GP64 of the baculovirus, Autographa californica multicapsid nucleopolyhedrovirus (right)
The virus particle is enveloped. It is generally spherical or ovoid, with a diameter in the range 80–120 nm.[15] Some filamentous forms are observed in THOV, Batken and Bourbon viruses.[6][8][16] The single-stranded, –RNA genome is linear and segmented, with six or seven segments of 0.9–2.3 kb and a total size of around 10 kb.[15][17] Reassortment of segments between strains has been observed in both ticks and mammals experimentally infected with more than one thogotovirus, but its significance in natural infections is unknown.[18]
Viral proteins
The genome encodes 7–9 proteins, including the trimeric RNA polymerase enzyme (PA, PB1, PB2) and the structural proteins nucleoprotein (NP), which binds the viral genome; matrix protein (M1), which lines the envelope; and an envelope glycoprotein (GP), which acts as the virus receptor.[14][15]
The thogotovirus glycoprotein is not similar to the influenza virus glycoproteins (haemagglutinin and neuraminidase), and instead shows some similarities with the gp64 glycoprotein of baculoviruses, which infect insects.[3][14][19] It also has some similarity with the haemagglutinin of Quaranfil virus, the type species of a new genus of tick-transmitted orthomyxoviruses.[20] The mechanism by which thogotoviruses gained a baculovirus-like glycoprotein is unknown. Pat Nuttall and colleagues have speculated that the acquisition enabled these viruses to infect ticks.[21] This apparent receptor specificity for arthropod cells does not prevent most thogotoviruses from infecting vertebrates.[14] The thogotovirus glycoprotein is classified as a class III or γ penetrene, lacking the fusion peptide present in influenza haemagglutinin (a class I or α penetrene).[22]
THOV and JOSV[1] also encode the protein M-long (ML), which counters the host's innate immunity, in particular by suppressing the production of interferon. This immune evasion is important for the virus to infect systemically in vertebrates, but is unnecessary in arthropods, which lack the interferon response. The mechanism of action of ML is completely different from the equivalent protein in influenza viruses (NS1).[14][15][23][24]
As in all orthomyxoviruses, the largest three segments (1–3) encode the three subunits of the RNA polymerase. In thogotoviruses, segment 4 encodes the glycoprotein and segment 5 the nucleoprotein. The messenger RNA (mRNA) from segment 6 can be spliced to encode the matrix protein or unspliced to encode ML, which has 38 additional amino acids at its C-terminus.[3][14][15][17] No product has yet been identified for the seventh segment, observed in DHOV.[17]
Life cycle
Electron micrograph showing endocytosis (arrows) of Bourbon virus (scale bar: 100 nm)
The receptor on the vertebrate host cell is sialic acid, which is bound by the viral glycoprotein. Entry is by endocytosis, with fusion of the viral and cell membranes occurring once the vesicle is acidified. In common with other orthomyxoviruses, viral transcription and replication both occur in the cell nucleus.[14][15] In some members of the genus, replication has been shown to be sensitive to the Mx1/MxA protein, which is induced in mice and humans in response to interferon.[8][25] In one study, this inhibitory effect was shown to be caused by MxA preventing the transport of the THOV genome into the nucleus.[26]
As orthomyxoviruses do not encode a capping enzyme, initiation of transcription involves the virus cutting the cap off the 5′-end of host mRNAs, so that the mRNA is recognised by the host translation machinery. A similar "cap snatching" process is used by other orthomyxoviruses, but a much longer host RNA sequence is cleaved along with the cap and incorporated into the viral mRNA.[27][28]
The virus assembles by the cell membrane and leaves the cell by budding.[15] For THOV grown in baby hamster kidney cells, virus particles start to be released 6–8 hours after infection, with substantial quantities still being produced 24 hours after infection. This growth rate is slower than that of influenza viruses, and is more similar to Quaranfil virus.[16][20]
Epidemiology
Most thogotoviruses have been shown to infect arthropods, generally hard or soft ticks, which are arachnids,[6] but in one case mosquitoes, which are insects.[8] Members also infect birds[14][29] and a wide range of wild and domestic mammals, including marsupials,[13] rodents,[3] hares,[30] mongoose,[31] horses,[5] camels, goats, sheep and cattle.[1][31] Three types – THOV, DHOV and Bourbon virus – have been shown to infect humans.[6] They have a wide geographical range.[6]
Transmission to vertebrates usually occurs via a tick vector. THOV persists in the tick, remaining in the organism as it goes through its developmental stages; this is called transstadial transmission.[16] The virus can be transmitted to another host within a day of attachment to the host.[32] THOV can be transmitted between ticks when they feed simultaneously on apparently uninfected guinea pigs, in the absence of a detectable level of virus in the blood.[33][34] Such nonviraemic transmission has also been observed with other predominantly tick-transmitted RNA viruses, including bluetongue, Crimean–Congo haemorrhagic fever, louping ill, tick-borne encephalitis, vesicular stomatitis virus and West Nile virus viruses.[25] Transmission of DHOV by respiratory aerosol has also been observed.[5]
Host interaction and disease
Ticks
No major pathological changes are observed in Rhipicephalus appendiculatus ticks infected with THOV.[16] The virus is concentrated in the synganglion (the tick brain) early on in the blood-feeding process, with the proportion of virus located in the salivary glands increasing during the late phase of blood-feeding.[16][32] Lower levels of virus are found in the trachea, digestive tract and female sex organs, but not in the male sex organs or the excretory system. The high level of virus present in the synganglion has been proposed to help the virus persist through the metamorphosis of the tick, as the nervous system undergoes less remodellng than other systems.[16]
Vertebrates
In the laboratory setting, several members of the genus cause severe disease in mice and hamsters.[4][5] Systemic spread of the virus occurs, with pathological effects present in multiple organs and systems, including the brain, liver, lymphatic system, and sometimes the lungs and small intestine.[4][5] Lymphocytes are a major target cell for DHOV.[5] DHOV infection in mice resembles experimental influenza infection in mice and ferrets as well as fatal H5N1 influenza infection of humans, and has been proposed as a model for this disease.[5]
Natural infections with thogotoviruses in mammals generally do not appear to result in symptoms. THOV is a significant veterinary pathogen, for example, causing a febrile illness and abortion in sheep.[4][35][36][37][38] As of February 2015, only eight cases of human disease associated with thogotoviruses have been reported: two with THOV, five with DHOV and one with Bourbon virus; there have been two fatalities.[6] The incubation period for THOV is 4–5 days.[38] All three viruses were associated with fever. THOV and DHOV also caused neurological symptoms: meningitis and neuromyelitis optica in the case of THOV; encephalitis in the case of DHOV.[6][7][12][38] Hepatitis has been observed with THOV.[38] The single case of disease in a person infected with Bourbon virus was associated with decreases in blood platelets and white cells; no neurological symptoms were observed.[6] Influenza-like respiratory symptoms have not been reported.[6][7]
Treatment and prevention
No specific treatment or vaccine is available for thogotoviruses, as of February 2015. The antiviral drug ribavirin, which has a broad spectrum of activity that includes some other orthomyxoviruses,[39] has been shown to inhibit DHOV replication in vitro in a single study.[40] Supportive therapy is used for THOV disease,[38] and has been recommended by the US Centers for Disease Control and Prevention for infection with Bourbon virus. As with other arboviruses, avoidance of contact with the vector is central to prevention.[41]
Species and strains
Two species have been confirmed by the ICTV, THOV (the type species) and DHOV.[42] The two viruses have a low degree of sequence identity (37% for the nucleoprotein; 31% for the envelope glycoprotein), and their antibodies do not crossreact.[12] Batken virus is a subtype of DHOV.[12] As of February 2015, a further five species or strains have been suggested as belonging to the genus.[6]
| Species/strain | RNA segments | Diameter (nm) | Vectors | Vertebrate hosts | Distribution |
|---|---|---|---|---|---|
| Araguari | 6 | 105 | Unknown | Gray four-eyed opossum, mouse | S. America |
| Aransas Bay | 6 | 75–140 | Ornithodoros ticks | Mouse | N. America |
| Batken | 50–100 | Hyalomma ticks, Aedes and Culex mosquitoes | Chicken, hamster, mouse | Asia | |
| Bourbon | ≥6 | ~100–130 | Unknown | Human | N. America |
| Dhori | 7 | Hyalomma ticks | Birds, hare, horse, human, mouse, ruminants | Africa, Asia, Europe | |
| Jos | ≥6 | 85–120 | Amblyomma and Rhipicephalus ticks | Mouse, zebu | Africa |
| Thogoto | 6 | 100 | Amblyomma, Hyalomma and Rhipicephalus ticks | Banded mongoose, donkey, human, rodents, ruminants | Africa, Asia, Europe |
| Upolu | 6 | 75–120 | Ornithodoros ticks | Mouse | Australia |
The type species is highlighted in bold. Refer to the text for references.
Phylogeny of selected orthomyxoviruses, based on the nucleocapsid protein (scale bar: amino acid substitutions per site)
THOV-like viruses
Thogoto virus (THOV)
THOV is the type species of the genus. First isolated from ticks gathered from cattle in the Thogoto Forest region of Kenya, near Nairobi, in 1960,[4] it is now known to be distributed across the African continent, and has also been found in Italy and Portugal in Europe, and Iran in the Middle East.[18][30][43] Despite this wide geographical range, the virus shows only limited variation.[43] Its vectors include various hard-bodied ticks, including Amblyomma, Hyalomma and Rhipicephalus species.[4][12][18][30][44]
Antibodies have been found to THOV in rats and many domestic animals, including goats, sheep, donkeys, camels, cattle and buffaloes, and the virus has been isolated from the wild banded mongoose (Mongos mungo).[12][31] It causes significant livestock disease, including a febrile illness and abortion in sheep.[4][35][36][37] In artificial laboratory infections, it is highly pathogenic in hamsters and also infects mice.[4] The virus is known to infect humans in natural settings.[6][30]
The virus particle is generally spherical with some filamentous forms; the diameter is around 100 nm.[16] The genome has six RNA segments.[3]
Araguari virus
The Araguari virus was first isolated from a Gray four-eyed opossum (Philander opossum) in Serra do Navio, Amapá, Brazil in 1969.[13] Its method of transmission is unknown.[5] In laboratory infections, it is pathogenic to mice. The virion is around 105 nm in diameter. The genome has six RNA segments. Based on partial sequence data the virus was found to be most closely related to THOV.[13]
Aransas Bay virus (ABV)
ABV was found in the Ornithodoros genus of soft-bodied tick in seabird nests in southern Texas, USA, in 1975; it was the first member of the genus to be found in North America.[6][14] No natural vertebrate host has been identified, but the virus is highly pathogenic to mice in laboratory infections. The virus particle is spherical or ovoid, with a range of sizes, from 75 nm × 85 nm to 120 nm × 140 nm. The genome has six RNA segments. It is most similar to UPOV, with some similarity to THOV and JOSV.[14]
Hyalomma marginatum is one of the vectors of DHOV
Jos virus (JOSV)
JOSV was first isolated from the zebu (Bos indicus) in Jos, Nigeria in 1967. It has since been found infecting Amblyomma and Rhipicephalus hard-bodied ticks in several countries across Africa. In the laboratory it causes severe pathology in mice. The virus particle has a variable, usually ovoid, morphology with a diameter of 85–120 nm. The genome contains at least six RNA segments.[1] It has some sequence similarities with UPOV and ABV.[14]
Upolu virus (UPOV)
UPOV was first isolated on Upolu Cay in the Great Barrier Reef, Australia in 1966, from soft-bodied ticks of the species Ornithodoros capensis associated with the sooty tern (Onychoprion fuscatus). No natural vertebrate host has been identified, but the virus is highly pathogenic to mice in laboratory infections. The virion can either be spherical, with a diameter in the range 75–95 nm, or slightly ovoid, with a range of dimensions from 75 nm × 85 nm to 105 nm × 120 nm. The genome has six RNA segments. It is most similar to ABV, with some similarity to THOV and JOSV.[14]
DHOV-like viruses
Dhori virus (DHOV)
DHOV was first isolated from Hyalomma dromedarii hard-bodied ticks infesting camels in Gujarat, India, in 1961.[5] It has since been observed in eastern Russia, Pakistan, Egypt, Saudi Arabia, Kenya and southern Portugal. The vector is usually a species of Hyalomma, such as H. marginatum.[5][12][30][45][46]
Where DHOV is prevalent, antibodies to the virus have been documented in camels, goats, horses, cattle and humans.[5][12] The virus has been isolated from a wild hare, Lepus europaeus.[30][47] DHOV can infect humans by the aerosol route after accidental laboratory exposure, causing a febrile illness and encephalitis.[5][7][30] Under laboratory conditions it is highly pathogenic for mice, and has been proposed as a model system for highly pathogenic influenza.[5] It has also been shown to infect birds, with the virus being isolated from a cormorant,[48] and antibodies being observed in waterfowl.[12][14]
DHOV has seven RNA segments.[12]
Electron micrograph of a filamentous form of Bourbon virus (scale bar: 100 nm)
Batken virus
Batken virus was first isolated from hard-bodied ticks of the species Hyalomma plumbeum plumbeum infesting sheep near the town of Batken, Kirghizia, now in Kyrgyzstan, in 1970.[8][29] It has also been found to infect mosquitoes of the species Aedes caspius Pallas and Culex hortensis Ficalbi, also in Kyrgyzstan.[49] Its geographical range is limited to Central Asia, Transcaucasia and the area to the north of the Caspian Sea.[49] In the laboratory it is highly pathogenic for mice, hamsters and chickens.[29] The virion is variable in shape, with spherical and filamentous forms being observed; it has a diameter of 50–100 nm.[8] Batken is considered a DHOV subtype; the viruses have a high degree of sequence identity (90% in the envelope glycoprotein; 96–98% in other proteins), and their antibodies crossreact.[12][49]
Bourbon virus
Bourbon virus was identified in 2014 by next-generation sequencing of a blood sample from a man from Bourbon County, Kansas, USA, who became ill a few days after being bitten by multiple ticks, and subsequently died. It is the only known thogotovirus to be associated with human disease in the Western hemisphere. As of February 2015, Bourbon virus has not been isolated from ticks, insects or non-human vertebrates. The virus is variable in shape, with filamentous as well as spherical forms; it has a diameter broadly in the range 100–130 nm. The genome contains at least six RNA segments. It is most similar to DHOV and Batken virus.[6]
Notes and references
- ^ a b c d e Bussetti AV, Palacios G, Travassos da Rosa A, et al. (2012), "Genomic and antigenic characterization of Jos virus", Journal of General Virology, 93: 293–98, doi:10.1099/vir.0.035121-0, PMC 3352346, PMID 21994326
- ^ Members of the recently ratified genus Quaranjavirus are also transmitted by ticks.[1]
- ^ a b c d e Kochs G, Bauer S, Vogt C, et al. (2010), "Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells", Journal of Virology, 84: 12344–50, doi:10.1128/jvi.00931-10
- ^ a b c d e f g h Haig DA, Woodall JP, Danskin D (1965), "Thogoto virus: a hitherto undescribed agent isolated from ticks in Kenya" (PDF), Journal of General Microbiology, 38: 389–94, doi:10.1099/00221287-38-3-389
- ^ a b c d e f g h i j k l m Mateo RI, Xiao SY, Lei H, DA Rosa AP, Tesh RB (2007), "Dhori virus (Orthomyxoviridae: Thogotovirus) infection in mice: a model of the pathogenesis of severe orthomyxovirus infection", American Journal of Tropical Medicine and Hygiene, 76: 785–90
- ^ a b c d e f g h i j k l m n Kosoy OI, Lambert AJ, Hawkinson DJ, et al. (2015) Novel Thogotovirus species associated with febrile illness and death, United States, 2014. Emerging Infectious Diseases doi:10.3201/eid2105.150150 (accessed 4 March 2015)
- ^ a b c d Butenko AM, Leshchinskaia EV, Semashko IV, Donets MA, Mart'ianova LI (1987), "[Dhori virus—a causative agent of human disease. 5 cases of laboratory infection]", Voprosy Virusologii (in Russian), 32: 724–29
- ^ a b c d e f g Frese M, Weeber M, Weber F, Speth V, Haller O (1997), "Mx1 sensitivity: Batken virus is an orthomyxovirus closely related to Dhori virus", Journal of General Virology, 78: 2453–58, doi:10.1099/0022-1317-78-10-2453
- ^ Clerx JP, Fuller F, Bishop DH (1983), "Tick-borne viruses structurally similar to Orthomyxoviruses", Virology, 127: 205–19, doi:10.1016/0042-6822(83)90384-7 CS1 maint: Multiple names: authors list (link)
- ^ ICTV 6th report (PDF), International Committee on Taxonomy of Viruses, retrieved 9 March 2015
- ^ Pringle CR, Virus Taxonomy 1996 - A Bulletin from the Xth International Congress of Virology in Jerusalem (PDF), International Committee on Taxonomy of Viruses, retrieved 9 March 2015
- ^ a b c d e f g h i j k Büchen-Osmond C, ed. (2006), "Index of Viruses - Orthomyxoviridae", ICTVdB - The Universal Virus Database, version 4, Columbia University, retrieved 8 March 2015
- ^ a b c d Da Silva EV, Da Rosa AP, Nunes MR, et al. (2005), "Araguari virus, a new member of the family Orthomyxoviridae: serologic, ultrastructural, and molecular characterization", American Journal of Tropical Medicine and Hygiene, 73: 1050–58
- ^ a b c d e f g h i j k l m Briese T, Chowdhary R, Travassos da Rosa A, et al. (2014), "Upolu virus and Aransas Bay virus, two presumptive bunyaviruses, are novel members of the family Orthomyxoviridae", Journal of Virology, 88: 5298–09, doi:10.1128/jvi.03391-13, PMC 4019087, PMID 24574415
- ^ a b c d e f g "Thogotovirus", ViralZone, Swiss Institute of Bioinformatics, retrieved 6 March 2015
- ^ a b c d e f g Booth TF, Davies CR, Jones LD, Staunton D, Nuttall PA (1989), "Anatomical basis of Thogoto virus infection in BHK cell culture and in the ixodid tick vector, Rhipicephalus appendiculatus", Journal of General Virology, 70: 1093–104, doi:10.1099/0022-1317-70-5-1093
- ^ a b c King AM, Adams MJ, Carstens EB, Lefkowitz EJ, eds. (2011), Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, Academic Press, p. 757
- ^ a b c Davies CR, Jones LD, Green BM, Nuttall PA (1987), "In vivo reassortment of Thogoto virus (a tick-borne influenza-like virus) following oral infection of Rhipicephalus appendiculatus ticks" (PDF), Journal of General Virology, 68: 2331–38, doi:10.1099/0022-1317-68-9-2331
- ^ Morse MA, Marriott AC, Nuttall PA (1992), "The glycoprotein of Thogoto virus (a tick-borne orthomyxo-like virus) is related to the baculovirus glycoprotein GP64", Virology, 186: 640–46, doi:10.1016/0042-6822(92)90030-s
- ^ a b Presti RM, Zhao G, Beatty WL, Mihindukulasuriya KA, Travassos da Rosa APA (2009), "Quaranfil, Johnston Atoll, and Lake Chad viruses are novel members of the family Orthomyxoviridae", Journal of Virology, 83: 11599–606, doi:10.1128/jvi.00677-09, PMC 2772707, PMID 19726499
- ^ Allison AB, Ballard JR, Tesh RB, Brown JD, Ruder MG, et al. (2015), "Cyclic avian mass mortality in the Northeastern United States is associated with a novel orthomyxovirus", Journal of Virology, 89: :1389–403
- ^ Garry CE, Garry RF (2008), "Proteomics computational analyses suggest that baculovirus GP64 superfamily proteins are class III penetrenes", Virology Journal, 5: 28, doi:10.1186/1743-422x-5-28, PMC 2288602, PMID 18282283
- ^ Haller O, Kochs G, Weber F (2006), "The interferon response circuit: Induction and suppression by pathogenic viruses", Virology, 344: 119–30, doi:10.1016/j.virol.2005.09.024
- ^ Thogoto virus: Molecular biology of a tick-transmitted Orthomyxovirus, Universitäts Klinikum Freiburg, retrieved 7 March 2015
- ^ a b Kuno G, Chang GJ (2005), "Biological Transmission of Arboviruses: Reexamination of and New Insights into Components, Mechanisms, and Unique Traits as Well as Their Evolutionary Trends", Clinical Microbiology Reviews, 18: 608–37, doi:10.1128/cmr.18.4.608-637.2005, PMC 1265912, PMID 16223950
- ^ Kochs G, Haller O (1999), "Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids", Proceedings of the National Academy of Sciences of the USA, 96: 2082–86, doi:10.1073/pnas.96.5.2082
- ^ Leahy MB, Dessens JT, Nuttall PA (1997), "In vitro polymerase activity of Thogoto virus: evidence for a unique cap-snatching mechanism in a tick-borne orthomyxovirus." (PDF), Journal of Virology, 71: 8347–51, PMC 192294, PMID 9343188
- ^ Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, et al. (2014), "Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains", PLOS ONE, 9: e84973, doi:10.1371/journal.pone.0084973, PMC 3893164, PMID 24454773
- ^ a b c Lvov DK, Karas FR, Tsyrkin YM, Vargina SG, Timofeev EM, et al. (1974), "Batken virus, a new arbovirus isolated from ticks and mosquitoes in Kirghiz S.S.R.", Archiv für die gesamte Virusforschung, 44: 70–73, doi:10.1007/bf01242183
- ^ a b c d e f g Gratz N (2006), Vector- and Rodent-Borne Diseases in Europe and North America: Distribution, Public Health Burden, and Control, Cambridge University Press, pp. 108–9
- ^ a b c Ogen-Odoi A, Miller BR, Happ CM, Maupin GO, Burkot TR (March 1999), "Isolation of thogoto virus (Orthomyxoviridae) from the banded mongoose, Mongos mungo (Herpestidae), in Uganda", American Journal of Tropical Medicine and Hygiene, 60 (3): 439–40, PMID 10466973
- ^ a b Kaufman WR, Nuttall PA (2003), "Rhipicephalus appendiculatus (Acari: Ixodidae): dynamics of Thogoto virus infection in female ticks during feeding on guinea pigs", Experimental Parasitology, 104: 20–25, doi:10.1016/s0014-4894(03)00113-9
- ^ Jones LD, Davies CR, Steele GM, Nuttall PA. (1987). A novel mode of arbovirus transmission involving a non-viremic host. Science 237: 775–77
- ^ Jones LD, Nuttall PA (1989), "Non-viraemic transmission of Thogoto virus: influence of time and distance", Trans. R. Soc. Trop. Med. Hyg., 83 (5): 712–24, doi:10.1016/0035-9203(89)90405-7, PMID 2617637
- ^ a b Duncanson GR (2013), Farm Animal Medicine and Surgery: For Small Animal Veterinarians, CABI, p. 110
- ^ a b Maramorosch K, McIntosh AH (1994), Arthropod Cell Culture Systems, CRC Press, p. 165
- ^ a b Frese M, Kochs G, Meier-Dieter U, Siebler J, Haller O (1995), "Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus", Journal of Virology, 69: 3904–09
- ^ a b c d e Berger SA, Calisher CH, Keystone JS (2003), Exotic Viral Diseases: A Global Guide, BC Decker, pp. 179–80
- ^ Sidwell RW, Huffman JH, Khare GP, Allen LB, Witkowski JT, Robins RK (August 1972), "Broad-spectrum antiviral activity of Virazole: 1-f8- D-ribofuranosyl-1,2,4-triazole-3-carboxamide", Science, 177: 705–6, doi:10.1126/science.177.4050.705, JSTOR 1734763, PMID 4340949 – via JSTOR, (registration required (help))
- ^ Belov AV, Larichev VF, Galkina IA, Khutoretskaia NV, Butenko AM, et al. (2008), "[In vitro activity of Russian ribavirin on the models of Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, and Tahyna and Dhori viruses]", Voprosy virusologii (in Russian), 53: 34–35
- ^ "Bourbon virus", CDC website, Division of Vector-Borne Diseases, CDC, retrieved 4 March 2015
- ^ ICTV Master Species List 2014 v2, International Committee on Taxonomy of Viruses, 2014, retrieved 7 March 2015
- ^ a b Calisher CH, Karabatsos N, Filipe AR (1987), "Antigenic uniformity of topotype strains of Thogoto virus from Africa, Europe, and Asia", American Journal of Tropical Medicine and Hygiene, 37: 670–73
- ^ Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, et al. (2006), "Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya", Emerging Infectious Diseases, 12: 1074–1080, doi:10.3201/eid1207.060253
- ^ Darwish MA, Hoogstraal H, Roberts TJ, Ghazi R, Amer T (1983), "A sero-epidemiological survey for Bunyaviridae and certain other arboviruses in Pakistan", Transactions of the Royal Society of Tropical Medicine and Hygiene, 77: 446–50, doi:10.1016/0035-9203(83)90108-6
- ^ Al-Khalifa MS, Diab FM, Khalil GM (2007), "Man-threatening viruses isolated from ticks in Saudi Arabia", Saudi Medical Journal, 28: 1864–67
- ^ L'vov DN, Dzharkenov AF, Aristova VA, Kovtunov AI, Gromashevskiĭ VL (2002), "[The isolation of Dhori viruses (Orthomyxoviridae, Thogotovirus) and Crimean-Congo hemorrhagic fever virus (Bunyaviridae, Nairovirus) from the hare (Lepus europaeus) and its ticks Hyalomma marginatum in the middle zone of the Volga delta, Astrakhan region, 2001]", Voprosy virusologii (in Russian), 47: 32–36
- ^ Iashkulov KB; Shchelkanov MIu; L'vov SS; Dzhambinov SD; Galkina IV; et al. (2008), "[Isolation of influenza virus A (Orthomyxoviridae, Influenza A virus), Dhori virus (Orthomyxoviridae, Thogotovirus), and Newcastle's disease virus (Paromyxoviridae, Avulavirus) on the Malyi Zhemchuzhnyi Island in the north-western area of the Caspian Sea]", Voprosy virusologii (in Russian), 53: 34–38
- ^ a b c Al'khovskiĭ SV; L'vov DK; Shchelkanov MIu; Shchetinin AM; Deriabin PG; et al. (2014), "[Genetic characterization of the Batken virus (BKNV) (Orthomyxoviridae, Thogotovirus) isolated from the Ixodidae ticks Hyalomma marginatum Koch, 1844 and the mosquitoes Aedes caspius Pallas, 1771, as well as the Culex hortensis Ficalbi, 1889 in the Central Asia]", Voprosy virusologii (in Russian), 59: 33–37
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- Albanesi M, Mancardi DA, Macdonald LE, Iannascoli B, Zitvogel L, Murphy AJ, Daëron M, Leusen JH, Bruhns P.SourceInstitut Pasteur, [corrected] Département d'Immunologie, Unité d'Allergologie Moléculaire et Cellulaire, [corrected] 75015 Paris, France.
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- Cell host & microbe.Cell Host Microbe.2012 Oct 18;12(4):598-604. doi: 10.1016/j.chom.2012.09.005.
- MxA is an interferon-induced dynamin-like GTPase with wide-ranging antiviral activity, which hinges upon detection of unique viral structures that differ across virus families. Despite elucidation of its structure, the basis of MxA antiviral specificity remains enigmatic. We used an evolution-guided
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- Tick-borne viruses in Europe.
- Hubálek Z, Rudolf I.SourceInstitute of Vertebrate Biology, v.v.i., Academy of Sciences of the Czech Republic, Květná 8, 60365, Brno, Czech Republic. zhubalek@brno.cas.cz
- Parasitology research.Parasitol Res.2012 Jul;111(1):9-36. doi: 10.1007/s00436-012-2910-1. Epub 2012 Apr 18.
- The aim of this review is to present briefly background information on 27 tick-borne viruses ("tiboviruses") that have been detected in Europe, viz flaviviruses tick-borne encephalitis (TBEV), louping-ill (LIV), Tyuleniy (TYUV), and Meaban (MEAV); orthobunyaviruses Bahig (BAHV) and Matruh (MTRV); ph
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Japanese Journal
- Isolation of the Thogoto virus from a Haemaphysalis longicornis in Kyoto City, Japan
- Journal of General Virology 96(8), 2099-2103, 2015-08
- NAID 120005820712
- Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids
- Proc Natl Acad Sci USA 96, 2082-2086, 1999
- NAID 80010997119
- Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus
- J Virol 69, 3904-3909, 1995
- NAID 80008286721
Related Links
- Het Thogoto Virus belongs to the Thogotoviruses and that makes it a direct relative of the influenza viruses because all are part of the larger family of Orthomyxoviruses. The genus Togotoviruses has seven distinct members: Thogoto ...
- O termo Thogoto virus é utilizado na Wikipedia de língua inglesa, onde se pode ler: Thogotovirus is a genus in the virus family Orthomyxoviridae. It can replicate in both tick cells and vertebrate cells and is usually transmitted by ticks. ...
Related Pictures
![Thogoto virus [2].](https://1mg.info/0/g/u/1412.jpg)
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