TXA2 receptor

• トロンボキサンA2受容体、トロンボキサンA2レセプター、TXA2受容体、TXA2レセプター

関

thromboxane A2 receptor

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. =sense organ / 受信装置
2. Texas

UpToDate Contents

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• 1. 遺伝性出血性毛細血管拡張症（オースラー・ウェーバー・ランデュ症候群） hereditary hemorrhagic telangiectasia osler weber rendu syndrome
• 2. 遺伝性血管浮腫：急性発作の治療 hereditary angioedema treatment of acute attacks
• 3. 冠動脈バイパス術の心臓以外の早期合併症 early noncardiac complications of coronary artery bypass graft surgery
• 4. 成人における急性上部消化管出血へのアプローチ approach to acute upper gastrointestinal bleeding in adults
• 5. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function

English Journal

• Revisiting the usefulness of thromboxane-A2 modulation in the treatment of bronchoconstriction in asthma.

• Hernandez JM1, Janssen LJ.
• Canadian journal of physiology and pharmacology.Can J Physiol Pharmacol.2015 Feb;93(2):111-7. doi: 10.1139/cjpp-2014-0364. Epub 2014 Dec 9.
• Airway smooth muscle (ASM) is the effector cell in the bronchoconstrictory pathway. It is believed that the bronchoconstriction present in asthma is associated with changes in the airway milieu that affect ASM excitation-contraction coupling and Ca(2+)-handling. Asthmatics also react differently to
• PMID 25581104

• Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling.

• Sumimoto S1, Muramatsu R2, Yamashita T3.
• Brain research.Brain Res.2015 Jan 12;1594:46-51. doi: 10.1016/j.brainres.2014.07.048. Epub 2014 Aug 7.
• Thromboxane A2 (TXA2) is a central prostanoid in the cardiovascular system and is a crucial mediator of vascular homeostasis and platelet aggregation. In this study, we report a novel role for TXA2 in neurite outgrowth. TXA2 receptor is expressed in rat cortical neurons, and treatment with the TXA2
• PMID 25108039

• Thromboxane A2 Receptor Polymorphism in Association with Cerebral Infarction and its Regulation on Platelet Function.

• Shao J, Fu Y, Yang W, Yan J, Zhao J, Chen S, Xia W1.
• Current neurovascular research.Curr Neurovasc Res.2015 Jan 2. [Epub ahead of print]
• Binding of thromboxane A2 (TXA2) to its receptor TXA2R modulates thrombosis/hemostasis and plays a vital role in the pathogenesis of cerebral infarction (CI). In this study, we investigated the relationship between TXA2R polymorphisms and CI in Chinese Han population and the effect on platelet funct
• PMID 25557379

Japanese Journal

• Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta

• Sato Kyosuke,Chino Daisuke,Kobayashi Tomoya,Obara Keisuke,Miyauchi Seiji,Tanaka Yoshio
• Journal of Smooth Muscle Research 49(0), 63-77, 2013
• … DHA exhibited a strong inhibitory effect on the sustained contractions induced by U46619, a TXA2 mimetic. … Although DHA and EPA have similar inhibitory potencies against prostanoid receptor-mediated contractions, they had a more potent inhibition against TXA2 receptor (TP receptor)-mediated contractions than against PGF2α receptor (FP receptor)-mediated responses. …
• NAID 130003382356

• Thromboxane A2 Mediates Iron-Overload Cardiomyopathy in Mice Through Calcineurin-Nuclear Factor of Activated T Cells Signaling Pathway

• Lin Heng,Li Hsiao-Fen,Lian Wei-Shiung,Chen Hsi-Hsien,Lan Yi-Fan,Lai Pei-Fang,Cheng Ching-Feng
• Circulation Journal 77(10), 2586-2595, 2013
• … Because thromboxane A2 (TXA2) and prostacyclin are the 2 major prostanoids in the cardiovascular system, and TXA2 plays a major role in vascular atherosclerosis and has pro-inflammatory characteristics, we intended to elucidate the role of TXA2 in iron-overload cardiomyopathy. …
• NAID 130003361810

• Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice

• Suzuki Yuh,Inoue Toshio,Yamamoto Atsuki [他],Sugimoto Yukio
• Biological and Pharmaceutical Bulletin 34(4), 507-510, 2011
• … However, there is little information regarding the prophylactic effect of thromboxane A2 (TXA2) receptor antagonist on allergic rhinitis. … Recent studies revealed that a TXA2 receptor antagonist ramatroban could block the prostaglandin D2 (PGD2) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). …
• NAID 130000657839

Related Links

• TBXA2R - Thromboxane A2 receptor - Homo sapiens (Human ...

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the ...

• TBXA2R thromboxane A2 receptor [ (human)]

Gene ID: 6915, updated on 6-Dec-2016 Summary This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis.

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★リンクテーブル★

リンク元	「トロンボキサンA2受容体」「thromboxane A2 receptor」「TXA2受容体」「TXA2レセプター」「トロンボキサンA2レセプター」
関連記事	「TXA2」「TX」

「トロンボキサンA2受容体」

　　[★]

英

thromboxane A2 receptor、TXA2 receptor

関

プロスタグランジンH2/トロンボキサンA2受容体、プロスタグランジンH2レセプター、トロンボキサンA2レセプター、TXA2レセプター、TXA2受容体

「thromboxane A2 receptor」

　　[★]

• トロンボキサンA2受容体

関

prostaglandin H2 receptor、prostaglandin H2-thromboxane A2 receptor、TXA2 receptor

「TXA2受容体」

　　[★]

英

TXA2 receptor

関

トロンボキサンA2受容体、トロンボキサンA2レセプター、TXA2レセプター

「TXA2レセプター」

　　[★]

英

TXA2 receptor

関

トロンボキサンA2受容体、トロンボキサンA2レセプター、TXA2受容体

「トロンボキサンA2レセプター」

　　[★]

英

TXA2 receptor

関

トロンボキサンA2受容体、TXA2レセプター、TXA2受容体

「TXA2」

　　[★] トロンボキサンA2

同

thromboxane A2

「TX」

　　[★]

• トロンボキサン thromboxane