TNF receptor-associated factor 5

TNF受容体関連因子5

関

TRAF5

WordNet

1. having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
2. a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
3. a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
4. any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
5. make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
6. be a contributing factor; "make things factor into a companys profitability"
7. any of the numbers (or symbols) that form a product when multiplied together
8. an independent variable in statistics
9. anything that contributes causally to a result; "a number of factors determined the outcome"
10. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
11. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
12. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
13. a concept whose truth can be proved; "scientific hypotheses are not facts"
14. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
15. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
16. the 20th letter of the Roman alphabet (同)t
17. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
2. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
3. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
4. tritiumの化学記号
5. =sense organ / 受信装置

UpToDate Contents

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• 1. ベーチェット病の病因 pathogenesis of behcets disease
• 2. 活性化プロテインＣ抵抗性および第V因子ライデン activated protein c resistance and factor v leiden
• 3. 稀な（劣性遺伝性）凝固異常 rare recessively inherited coagulation disorders
• 4. 後天性の凝固因子阻害物質 acquired inhibitors of coagulation
• 5. 腫瘍壊死因子受容体-1関連周期性発熱症候群（TRAPS） tumor necrosis factor receptor 1 associated periodic syndrome traps

English Journal

• Disruption of tumor necrosis factor receptor associated factor 5 exacerbates pressure overload cardiac hypertrophy and fibrosis.

• Bian Z1, Dai J, Hiroyasu N, Guan H, Yuan Y, Gan L, Zhou H, Zong J, Zhang Y, Li F, Yan L, Shen D, Li H, Tang Q.
• Journal of cellular biochemistry.J Cell Biochem.2014 Feb;115(2):349-58. doi: 10.1002/jcb.24669.
• The cytoplasmic signaling protein tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5), which was identified as a signal transducer for members of the TNF receptor super-family, has been implicated in several biological functions in T/B lymphocytes and the innate immune response against
• PMID 24038435

• TRAF5 negatively regulates TLR signaling in B lymphocytes.

• Buchta CM1, Bishop GA.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Jan 1;192(1):145-50. doi: 10.4049/jimmunol.1301901. Epub 2013 Nov 20.
• The cytoplasmic adaptor proteins TNFR-associated factor (TRAF)3 and TRAF6 are important mediators of TLR signaling. To our knowledge, we show in this study for the first time that another TRAF family member, TRAF5, is a negative regulator of TLR signaling. B lymphocytes from TRAF5(-/-) mice produced
• PMID 24259503

• A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.

• Luo Q1, Sun Y, Liu W, Qian C, Jin B, Tao F, Gu Y, Wu X, Shen Y, Xu Q.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 Nov 15;191(10):4969-78. doi: 10.4049/jimmunol.1300832. Epub 2013 Oct 11.
• Iguratimod, a novel disease-modifying antirheumatic drug, which is now used in clinics in China and Japan, has been confirmed as a highly efficacious and safe drug for rheumatoid arthritis therapy. The antiarthritic mechanism of iguratimod, especially compared with that of the classical disease-modi
• PMID 24123677

Japanese Journal

• Dietary zinc supplementation increased TNFα and IL1β-induced RANKL expression, resulting in a decrease in bone mineral density in rats

• Journal of Clinical Biochemistry and Nutrition 58(1), 48-55, 2016
• NAID 130005116631

• Dietary zinc supplementation increased TNFα and IL1β-induced RANKL expression, resulting in a decrease in bone mineral density in rats

• Journal of Clinical Biochemistry and Nutrition advpub(0), 2016
• NAID 130005110589

• A Case Presenting with the Clinical Characteristics of Tumor Necrosis Factor (TNF) Receptor-associated Periodic Syndrome (TRAPS) without TNFRSF1A Mutations Successfully Treated with Tocilizumab

• Internal Medicine 54(16), 2069-2072, 2015
• NAID 130005092892

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★リンクテーブル★

リンク元	「TRAF5」「TNF受容体関連因子5」
関連記事	「associate」「fact」「TNF receptor」「factor」「T」

「TRAF5」

　　[★]

• TNF受容体関連因子5

関

TNF receptor-associated factor 5

「TNF受容体関連因子5」

　　[★]

英

TNF receptor-associated factor 5、TRAF5

「associate」

　　[★]

• vt.

• 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる

• vi.

• 仲間/友人などとして交際する(with)。一つにまとめる、連合する

• n.

• 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
• 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
• 連想によって心に浮かぶ言葉/思い、連想物

• adj.

• 仲間の、同僚の。製紙機械員に次ぐ資格の
• 付随する、連想される

関

accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union

　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「TNF receptor」

　　[★]

• 腫瘍壊死因子受容体、腫瘍壊死因子レセプター、TNF受容体、TNFレセプター

関

TNFR、tumor necrosis factor receptor

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「T」

　　[★]

• T波 T wave
• チミン thymine
• ツイスト数
• スレオニントレオニン threonine