Extra-transcriptional functions of RNA Polymerase III complexes: TFIIIC as a potential global chromatin bookmark.
Donze D.AbstractRNA polymerase III (Pol III) is one of three eukaryotic transcription complexes, and was identified as the complex responsible for production of transfer RNA and a limited number of other small RNAs. Pol III transcription at tRNA genes (tDNAs) requires the binding of two transcription factor complexes, TFIIIC and TFIIIB. Recent evidence points to a larger role for the Pol III transcription system in various other nuclear processes, including effects on nucleosome positioning, global genome and sub-nuclear organization, and direct effects on RNA polymerase II (Pol II) transcription. These effects are perhaps mediated by recruitment of a host of other chromatin proteins, including Pol II transcription factors and chromatin enzymes. Extra-TFIIIC sites (ETC sites) are chromosomal locations bound by TFIIIC without the rest of the Pol III complex, and bound TFIIIC alone is also able to mediate additional functions. These so called "extra-transcriptional effects" of the Pol III system are reviewed here, and a model is put forth suggesting that the TFIIIC transcription factor may act as a stably bound, global "bookmark" within chromatin to establish, maintain, or demarcate chromatin states as cells divide or change gene expression patterns.
Gene.Gene.2011 Oct 1. [Epub ahead of print]
RNA polymerase III (Pol III) is one of three eukaryotic transcription complexes, and was identified as the complex responsible for production of transfer RNA and a limited number of other small RNAs. Pol III transcription at tRNA genes (tDNAs) requires the binding of two transcription factor complex
Yeast Rrn7 and human TAF1B are TFIIB-related RNA polymerase I general transcription factors.
Knutson BA, Hahn S.SourceFred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue N, Post Office Box 19024, Mailstop A1-162, Seattle, WA 98109, USA.
Science (New York, N.Y.).Science.2011 Sep 16;333(6049):1637-40.
Eukaryotic and archaeal multisubunit RNA polymerases (Pols) are structurally related and require several similar components for transcription initiation. However, none of the Pol I factors were known to share homology with transcription factor IIB (TFIIB) or TFIIB-related proteins, key factors in th
What is the meaning of TFIIIB acronym/abbreviation and what does TFIIIB stand for? Get the Definition of TFIIIB and TFIIIB definition by All Acronyms Dictionary - 2 TFIIIB acronym and abbreviation records for your search.
TFIIIB can bind independently of TFIIIC to TATA boxes that are present upstream of SNR6 and a few tRNA genes in vitro (20, 21), but its assembly onto DNA is entirely dependent on TFIIIC in vivo and in the context of chromatin in vitro ...