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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/17 13:19:09」(JST)

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Transcription factor II H (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.^[1] TFIIH consists of ten subunits, 7 of which (XPD, XPB, p62, p52, p44, p34 and TTDA) form the core complex. The cyclin activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein ^[2] Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or if it is supercoiled. Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle. Next to a vital function in transcription initiation, TFIIH is also involved in nucleotide excision repair.

References

^ Kim TK, Ebright RH, Reinberg D (2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH". Science 288 (5470): 1418–22. doi:10.1126/science.288.5470.1418. PMID 10827951.
^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.

External links

Transcription+Factor+TFIIH at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 脱毛の評価および診断 evaluation and diagnosis of hair loss

English Journal

Evidence for a Complex of Transcription Factor IIB (TFIIB) with Poly(A) Polymerase and Cleavage Factor 1 Subunits Required for Gene Looping.

Medler S, Al Husini N, Raghunayakula S, Mukundan B, Aldea A, Ansari A.SourceFrom the Department of Biological Science, Wayne State University, Detroit, Michigan 48202.
The Journal of biological chemistry.J Biol Chem.2011 Sep 30;286(39):33709-18. Epub 2011 Aug 11.
Gene looping, defined as the interaction of the promoter and the terminator regions of a gene during transcription, requires transcription factor IIB (TFIIB). We have earlier demonstrated association of TFIIB with the distal ends of a gene in an activator-dependent manner (El Kaderi, B., Medler, S.,
PMID 21835917

Japanese Journal

基本転写因子TFIIEの構造とTFIIHとの相互作用

奥田昌彦,西村善文
生化学 80(6), 501-510, 2008-06-25
NAID 10021192114

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拡張検索	「転写因子TFIIH」「transcription factor TFIIH」

「転写因子TFIIH」

general transcription factor IIH, polypeptide 3, 34kDa
Identifiers
Symbol	GTF2H3
Alt. symbols	BTF2, TFIIH
Entrez	2967
HUGO	4657
OMIM	601750
RefSeq	NM_001516
UniProt	Q13889
Other data
Locus	Chr. 12 q24.31

general transcription factor IIH, polypeptide 2, 44kDa
Identifiers
Symbol	GTF2H2
Alt. symbols	BTF2, TFIIH, BTF2P44, T-BTF2P44
Entrez	2966
HUGO	4656
OMIM	601748
RefSeq	NM_001515
UniProt	Q13888
Other data
Locus	Chr. 5 q12.2-13.3

general transcription factor IIH, polypeptide 1, 62kDa
Identifiers
Symbol	GTF2H1
Alt. symbols	BTF2
Entrez	2965
HUGO	4655
OMIM	189972
RefSeq	NM_005316
UniProt	P32780
Other data
Locus	Chr. 11 p15.1-p14