Sulfamylon

マフェニド

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/13 18:46:42」(JST)

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Mafenide

Systematic (IUPAC) name
4-(Aminomethyl)benzenesulfonamide
Clinical data
Trade names	Sulfamylon
AHFS/Drugs.com	monograph
Legal status	℞ (Prescription only)
Routes of administration	Topical
Identifiers
CAS Number	138-39-6 N
ATC code	D06BA03
PubChem	CID 3998
ChemSpider	3858 Y
UNII	58447S8P4L Y
KEGG	D02351 Y
ChEMBL	CHEMBL419 Y
Chemical data
Formula	C7H10N2O2S
Molar mass	186.233 g/mol
SMILES O=S(=O)(c1ccc(cc1)CN)N
InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) Y Key:TYMRLRRVMHJFTF-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.

Uses

Mafenide is used to treat severe burns. It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.

Mechanism of action

Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.

Adverse reactions

Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.

Drug interactions

There are no significant interactions.

Contraindications

Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.

Dosage

For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.

References

External links

• Mafenide information on RxList

UpToDate Contents

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• 1. 熱傷の局所治療：外用抗菌薬と被覆材 local treatment of burns topical antimicrobial agents and dressings
• 2. 熱傷再建の原則：顔面、頭皮、および頸部 principles of burn reconstruction face scalp and neck
• 3. Treatment of superficial burn wounds requiring hospital admission
• 4. 壊死性軟部組織感染症への外科的マネージメント surgical management of necrotizing soft tissue infections
• 5. 大災害および戦争による熱傷のマネージメントの原則 management principles for burns resulting from mass disasters and war casualties

English Journal

• The Effect of Antiseptics on Adipose-Derived Stem Cells.

• Kim BS1, Ott V, Boecker AH, Stromps JP, Paul NE, Alharbi Z, Cakmak E, Bernhagen J, Bucala R, Pallua N.
• Plastic and reconstructive surgery.Plast Reconstr Surg.2017 Mar;139(3):625-637. doi: 10.1097/PRS.0000000000003125.
• PMID 28234837

• 2.5% Mafenide Acetate: A Cost-Effective Alternative to the 5% Solution for Burn Wounds.

• Afshari A1, Nguyen L, Kahn SA, Summitt B.
• Journal of burn care & research : official publication of the American Burn Association.J Burn Care Res.2017 Jan/Feb;38(1):e42-e47. doi: 10.1097/BCR.0000000000000425.
• PMID 27606553

• Hydrofiber Dressing Saturated With Mafenide Acetate Extends the Duration of Antimicrobial Activity.

• Kahn SA1, Afshari A, Nguyen L, Shinha T, Huff T, Montgomery AC, Stratton C, Summitt B.
• Journal of burn care & research : official publication of the American Burn Association.J Burn Care Res.2016 Oct 13. [Epub ahead of print]
• PMID 27775984

Japanese Journal

• The efficacy of 5% sulfamylon solution for the treatment of contaminated explanted human meshed skin grafts

• MAGGI SP
• Burns 25, 237-241, 1999
• NAID 30008793748

• 熱傷受傷時における肺変化に関する病理学的研究:(II) 実験的熱傷時における肺変化に関する超微形態学的研究

• 久野 佑三
• 日本医科大学雑誌 46(1), 45-50_6, 1979
• A remarkable progress in clinical therapeutic aspects on the thermal burns has been made recently. Preventions of the infections and subsequent septic shock with Gramnegative bacilli have been achieve …
• NAID 130003917825

• 熱傷受傷時における肺変化に関する病理学的研究:(I) 人体病理学的研究

• 久野 佑三
• 日本医科大学雑誌 46(1), 40-44_5, 1979
• … Above all, one of the most remarkable change is a decrease of the burn wound sepsis due to the improvement of topical applications of sulfamylon cream and silver sulfadiazine, and an increase of the pulmonary complications, such as pneumonia, pleuritis, pulmonary edema etc.. …
• NAID 130003917824

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「マフェニド」

「マフェニド」

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英

mafenide

化

酢酸マフェニド mafenide acetate

同

マフェナイド

商

Sulfamylon

• 局所抗菌薬