WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
ポタシウム,カリウム(金属元素;化学記号はK)

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1. 心筋活動電位および抗不整脈剤の作用 myocardial action potential and action of antiarrhythmic drugs
2. 赤血球水分量の制御 control of red blood cell hydration
3. QT延長症候群の病態生理 pathophysiology of the long qt syndrome
4. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
5. 先天性および後天性ＱＴ延長症候群の遺伝学 genetics of congenital and acquired long qt syndrome

First de novo KCND3 mutation causes severe Kv4.3 channel dysfunction leading to early onset cerebellar ataxia, intellectual disability, oral apraxia and epilepsy.

Smets K1,2,3, Duarri A4, Deconinck T5,6, Ceulemans B7, van de Warrenburg BP8, Züchner S9, Gonzalez MA10, Schüle R11,12,13, Synofzik M14,15, Van der Aa N16,17, De Jonghe P18,19,20, Verbeek DS21, Baets J22,23,24.
BMC medical genetics.BMC Med Genet.2015 Jul 21;16:51. doi: 10.1186/s12881-015-0200-3.
BACKGROUND: Identification of the first de novo mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) in a patient with complex early onset cerebellar ataxia in order to expand the genetic and phenotypic spectrum.METHODS: Whole exome sequencing in a cerebellar ataxia
PMID 26189493

Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.

Del Pino J1, Frejo MT2, Baselga MJ3, Capo MA2, Moyano P3, García JM3, Díaz MJ2.
Toxicology.Toxicology.2015 Jul 3;333:107-17. doi: 10.1016/j.tox.2015.04.013. Epub 2015 Apr 24.
4-Aminopyridine (4-AP) is a potassium channel blocker used for the treatment of neuromuscular disorders. Otherwise, it has been described to produce a large number of adverse effects among them cell death mediated mainly by blockage of K(+) channels. However, a protective effect against cell death h
PMID 25917026

Bougis PE1, Martin-Eauclaire MF2.
Sheng li xue bao : [Acta physiologica Sinica].Sheng Li Xue Bao.2015 Jun 25;67(3):248-54.
Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to
PMID 26109297