セルトリ細胞腫、Sertoli細胞腫
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/15 21:56:45」(JST)
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This article's factual accuracy is disputed. Please help to ensure that disputed statements are reliably sourced. See the relevant discussion on the talk page. (May 2014) |
| Sertoli cell tumour |
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Micrograph of a Sertoli cell tumour. H&E stain.
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| Classification and external resources |
| Specialty |
oncology |
| ICD-9-CM |
183.0, 256.1 |
| ICD-O |
8631 |
| MeSH |
D012707 |
A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a Sex cord-gonadal stromal tumor of a Sertoli cells. Although Sertoli cells normally occur only in the testis, this type of tumor may also rarely occur in the ovary of females.[1]
A tumor that produces both Sertoli cells and Leydig cells is known as a Sertoli-Leydig cell tumor.
Contents
- 1 Presentation
- 2 Diagnosis
- 3 Treatment
- 4 In non-humans
- 5 Additional images
- 6 See also
- 7 Notes
- 8 External links
Presentation
Due to excess estrogen secreted by these tumours, one-third of male patients may present with a recent history of progressive feminization.
Diagnosis
Low magnification micrograph of a
Sertoli cell tumour. H&E stain.
Presence of an ovarian tumour plus hormonal disturbances suggests a Leydig cell tumour, granulosa cell tumour or thecoma. However, hormonal disturbances, in Leydig tumours, is present in only 2/3 of cases. A conclusive diagnosis is made via histology, as part of a pathology report made during or after surgery. See also Sex cord-stromal tumour.
Treatment
The usual treatment is surgery. The surgery in women is usually a fertility-sparing unilateral salpingo-oophorectomy. For malignant tumours, the surgery may be radical and usually is followed by adjuvant chemotherapy, sometimes by radiation therapy. In all cases, initial treatment is followed by surveillance. Because in many cases Leydig cell tumour does not produce elevated tumour markers,[2] the focus of surveillance is on repeated physical examination and imaging.
The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant.[citation needed] For malignant tumours with undifferentiated histology, prognosis is poor.[2]
In non-humans
Sertoli cell tumors are known to occur in other species, including domestic ducks,[3] dogs,[4][5] and horses.
Additional images
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Micrograph of a Leydig cell tumour.
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Micrograph of a Leydig cell tumour.
See also
- Androgen-dependent syndromes
- Leydig cell tumour
- Sertoli-Leydig cell tumour
- Sertoli cell nodule
Notes
- ^ Oliva E, Alvarez T, Young RH (February 2005). "Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases". Am. J. Surg. Pathol. 29 (2): 143–56. doi:10.1097/01.pas.0000149692.21205.9c. PMID 15644771.
- ^ a b Lenhard M, Kuemper C, Ditsch N, Diebold J, Stieber P, Friese K, Burges A (2007). "Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell tumours". Clin. Chem. Lab. Med. 45 (5): 657–61. doi:10.1515/CCLM.2007.120. PMID 17484630.
- ^ Leach S, Heatley JJ, Pool RR, Spaulding K (December 2008). "Bilateral testicular germ cell-sex cord-stromal tumor in a pekin duck (Anas platyrhynchos domesticus)". J. Avian Med. Surg. 22 (4): 315–9. doi:10.1647/2007-017.1. PMID 19216259.
- ^ Gopinath D, Draffan D, Philbey AW, Bell R (December 2008). "Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour". J Small Anim Pract 50 (4): 198–200. doi:10.1111/j.1748-5827.2008.00671.x. PMID 19037884.
- ^ Vegter AR, Kooistra HS, van Sluijs FJ, van Bruggen LW, Ijzer J, Zijlstra C, Okkens AC (October 2008). "Persistent Mullerian Duct Syndrome in a Miniature Schnauzer Dog with Signs of Feminization and a Sertoli Cell Tumour". Reprod. Domest. Anim. 45 (3): 447–52. doi:10.1111/j.1439-0531.2008.01223.x. PMID 18954385.
External links
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Gonadal tumors, paraganglioma, and glomus (ICD-O 8590-8719)
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Gonadal/
sex cord-gonadal stromal |
| sex cord |
- Granulosa cell tumour
- Sertoli cell tumour
- Sex cord tumour with annular tubules
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| stroma |
- Thecoma
- Leydig cell tumor
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| both |
- Sertoli-Leydig cell tumour
- Luteoma
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Paragangliomas and
Glomus tumors |
- Neuroendocrine tumor
- Paraganglioma
- Pheochromocytoma
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- Vascular tissue neoplasm
- Glomus tumor
- Glomangiosarcoma
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Index of reproductive medicine
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| Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
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| Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
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Tumors: female urogenital neoplasia (C51–C58/D25–D28, 179–184/218–221)
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| Adnexa |
| Ovaries |
Glandular and epithelial/
surface epithelial-
stromal tumor |
| CMS: |
- Ovarian serous cystadenoma
- Mucinous cystadenoma
- Cystadenocarcinoma
- Papillary serous cystadenocarcinoma
- Krukenberg tumor
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- Endometrioid tumor
- Clear-cell ovarian carcinoma
- Brenner tumour
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| Sex cord-gonadal stromal |
- Leydig cell tumour
- Sertoli cell tumour
- Sertoli-Leydig cell tumour
- Thecoma
- Granulosa cell tumour
- Luteoma
- Sex cord tumour with annular tubules
- Steroid cell tumor (NOS)
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| Germ cell |
- Dysgerminoma
- Nongerminomatous
- Embryonal carcinoma
- Endodermal sinus tumor
- Gonadoblastoma
- Teratoma/Struma ovarii
- Choriocarcinoma
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| Fibroma |
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| Fallopian tube |
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| Uterus |
| Myometrium |
- Uterine fibroids/leiomyoma
- Leiomyosarcoma
- Adenomyoma
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| Endometrium |
- Endometrioid tumor
- Uterine papillary serous carcinoma
- Clear cell carcinoma
- Endometrial intraepithelial neoplasia
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| Cervix |
- Cervical intraepithelial neoplasia
- SCC
- Glassy cell carcinoma
- Villoglandular adenocarcinoma
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| Placenta |
- Choriocarcinoma
- Gestational trophoblastic disease
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| General |
- Uterine sarcoma
- Mixed Müllerian tumor
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| Vagina |
- SCC
- Botryoid rhabdomyosarcoma
- Clear cell adenocarcinoma of the vagina
- Vaginal intraepithelial neoplasia
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| Vulva |
- SCC
- Melanoma
- Papillary hidradenoma
- Extramammary Paget's disease
- Vulvar intraepithelial neoplasia
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Index of reproductive medicine
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| Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
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| Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
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- Tumors: male urogenital neoplasia (C60–C63/D29, 185–187/222)
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| Internal |
| Testicles |
Sex cord-
gonadal stromal |
- Sertoli-Leydig cell tumour
- Sertoli cell tumour
- Leydig cell tumour
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| Germ cell |
| G |
- Seminoma
- Spermatocytic seminoma
- Intratubular germ cell neoplasia
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| NG |
- Embryonal carcinoma
- Endodermal sinus tumor
- Gonadoblastoma
- Teratoma
- Choriocarcinoma
- Embryoma
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| Prostate |
- Adenocarcinoma
- High-grade prostatic intraepithelial neoplasia
- Small-cell carcinoma
- Transitional cell carcinoma
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| External |
| Penis |
- Carcinoma
- Extramammary Paget's disease
- Bowen's disease
- Bowenoid papulosis
- Erythroplasia of Queyrat
- Hirsuties coronae glandis
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|
|
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Index of reproductive medicine
|
|
| Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
|
|
| Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
|
|
|
UpToDate Contents
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English Journal
- DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.
- de Kock L1, Terzic T, McCluggage WG, Stewart CJR, Shaw P, Foulkes WD, Clarke BA.
- The American journal of surgical pathology.Am J Surg Pathol.2017 Sep;41(9):1178-1187. doi: 10.1097/PAS.0000000000000895.
- PMID 28654427
- Benign Large-cell Calcifying Sertoli Tumor of the Testis in a 13-Year-Old Male Patient Treated With Partial Orchiectomy.
- Tracey AJ1, Cerwinka WH2.
- Urology.Urology.2017 Sep;107:226-228. doi: 10.1016/j.urology.2017.05.023. Epub 2017 May 24.
- PMID 28551172
- Unusual presentations of Carney Complex in patient with a novel PRKAR1A mutation.
- Akin S1, Noyan S2, Dagdelen S1, Pasaoglu I3, Kaynaroglu V4, Askun MM5, Bilen CY6, Kiratli H7, Baydar DE8, Onder S8, Sokmensuer C8, Aytemir K9, Erkin G10, Kiratli PO11, Alikasifoglu M12, Erbas T1.
- Neuro endocrinology letters.Neuro Endocrinol Lett.2017 Aug 5;38(4):248-254. [Epub ahead of print]
- PMID 28871709
Japanese Journal
- B-6)横紋筋への分化を示すSertoli-Leydig cell tumorの1例(B 肺,肝,卵巣腫瘍,2010年度小児腫瘍症例検討会)
- P2-3-4 インスリン抵抗性改善薬pioglitazone投与とダイエットが奏効したSertoli-Leydig cell tumor摘出後の2次性PCOS症例からの新知見(Group75 生殖医学(症例)3,一般演題,第63回日本産科婦人科学会学術講演会)
- 清水 亜由美,遠藤 俊明,長澤 邦彦,馬場 剛,高田 さくら,高橋 円,石岡 伸一,斎藤 豪
- 日本産科婦人科學會雜誌 63(2), 715, 2011-02-01
- NAID 110008509569
Related Pictures
★リンクテーブル★
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- 英
- Sertoli cell tumor
- 同
- Sertoli細胞腫
- 関
- セルトリ・ライディッヒ細胞腫、性索間質性腫瘍。セルトリ細胞
精巣のセルトリ細胞腫
卵巣のセルトリ細胞腫
[★]
- 英
- Sertoli cell tumor
- 関
- セルトリ細胞腫
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[★]
細胞