WordNet
- an earthball with a smooth upper surface that is at first buried in sand; the top of the fruiting body opens up to form segments like the ray of an umbel (同)star earthball
- an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin (同)dermatosclerosis
- genus of poisonous fungi having hard-skinned fruiting bodies: false truffles (同)genus Scleroderma
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English Journal
- Localized scleroderma variants: pharmacologic implications.
- Jackson CT1, Maibach HI.Author information 1Dermatology Department, University of California Medical Center , San Francisco, California , USA.AbstractScleroderma, a complex syndrome, is a disease with varied, yet presumably related subtypes. We searched articles relating to localized scleroderma. By detailing these similarities and differences we gain increased knowledge. Furthermore, by understanding parallels and dissimilarities, possible mechanisms and interventions should be clarified.
- The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):529-31. doi: 10.3109/09546634.2012.723123. Epub 2012 Sep 19.
- Scleroderma, a complex syndrome, is a disease with varied, yet presumably related subtypes. We searched articles relating to localized scleroderma. By detailing these similarities and differences we gain increased knowledge. Furthermore, by understanding parallels and dissimilarities, possible mecha
- PMID 22905721
- Human diseases of the SSU processome.
- Sondalle SB1, Baserga SJ2.Author information 1Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: samuel.sondalle@yale.edu.2Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: susan.baserga@yale.edu.AbstractRibosomes are the cellular machines responsible for protein synthesis. Ribosome biogenesis, the production of ribosomes, is a complex process involving pre-ribosomal RNA (rRNA) cleavages and modifications as well as ribosomal protein assembly around the rRNAs to create the functional ribosome. The small subunit (SSU) processome is a large ribonucleoprotein (RNP) in eukaryotes required for the assembly of the SSU of the ribosome as well as for the maturation of the 18S rRNA. Despite the fundamental nature of the SSU processome to the survival of any eukaryotic cell, mutations in SSU processome components have been implicated in human diseases. Three SSU processome components and their related human diseases will be explored in this review: hUTP4/Cirhin, implicated in North American Indian childhood cirrhosis (NAIC); UTP14, implicated in infertility, ovarian cancer, and scleroderma; and EMG1, implicated in Bowen-Conradi syndrome (BCS). Diseases with suggestive, though inconclusive, evidence for the involvement of the SSU processome in their pathogenesis are also discussed, including a novel putative ribosomopathy. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jun;1842(6):758-64. doi: 10.1016/j.bbadis.2013.11.004. Epub 2013 Nov 12.
- Ribosomes are the cellular machines responsible for protein synthesis. Ribosome biogenesis, the production of ribosomes, is a complex process involving pre-ribosomal RNA (rRNA) cleavages and modifications as well as ribosomal protein assembly around the rRNAs to create the functional ribosome. The s
- PMID 24240090
- A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica.
- Iyer A1, Elsone L, Appleton R, Jacob A.Author information 1The Walton Centre for Neurology and Neurosurgery , Liverpool , UK and.AbstractAbstract Neuromyelitis optica (NMO) is an immune-mediated neurological disorder characterised by recurrent episodes of optic neuritis and longitudinally extensive transverse myelitis. A serum biomarker, aquaporin-4 IgG, the autoantibody against aquaporin-4 water channel, has been specifically associated with NMO and has assisted early recognition and prediction of relapses. Less commonly, a monophasic course, associated with antibodies to myelin oligodendrocyte glycoprotein has been reported. Specific diagnostic criteria have been defined; however, some cases that do not fulfil these criteria (but are nevertheless associated with aquaporin-4 IgG) are classified as NMO spectrum disorder and follow the same relapsing course. An ever-growing list of autoimmune disorders, both organ-specific and non-organ-specific, have been associated in up to 20-30% of patients with NMO. These disorders, which may become symptomatic before or after the development of NMO, are often diagnosed long after the diagnosis of NMO, as symptoms may be wrongly attributed to NMO, its residual effects or medication side effects. In addition, autoantibodies can be found in patients with NMO without coexisting disease (up to 40% in some series) and maybe suggestive of a heightened humoral immune response. We present a comprehensive review of the current literature on autoimmune disorders co-existing with NMO and identified 22 autoimmune conditions (myasthenia gravis, coeliac disease, ulcerative colitis, sclerosing cholangitis, systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid antibody syndrome, Sjogren's syndrome, autoimmune hypothyroidism, immune thrombocytopenic purpura, pernicious anaemia, narcolepsy, pemphigus foliaceus, alopecia areata, psoriasis, scleroderma, dermatitis herpetiformis, polymyositis, chronic inflammatory demyelinating polyneuropathy, paraneoplastic disorders, insulin dependent diabetes mellitus and autoimmune encephalitis).
- Autoimmunity.Autoimmunity.2014 May;47(3):154-61. doi: 10.3109/08916934.2014.883501. Epub 2014 Feb 10.
- Abstract Neuromyelitis optica (NMO) is an immune-mediated neurological disorder characterised by recurrent episodes of optic neuritis and longitudinally extensive transverse myelitis. A serum biomarker, aquaporin-4 IgG, the autoantibody against aquaporin-4 water channel, has been specifically associ
- PMID 24512514
Related Links
- 【Scleroderma flavidium】の意味・和訳。無料オンライン英語辞書『英ナビ!辞書』は英和辞典から単語検索が可能。意味・発音・使い方などが分かります。 ... 初めは砂に埋められ、滑らかな上部の表面のあるセイヨウショウロ an earthball ...
- an earthball with a smooth upper surface that is at first buried in sand; the top of the fruiting body opens up to form segments like the ray of an umbel