WordNet

a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
German statesman who served as chancellor of Germany (born in 1918) (同)Helmut Schmidt, Helmut Heinrich Waldemar Schmidt

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(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/24 10:45:41」(JST)

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Autoimmune polyendocrine syndrome type 2, a form of autoimmune polyendocrine syndrome also known as Schmidt's syndrome,^[1] or APS-II, is the most common form of the polyglandular failure syndromes.^[2] It is heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular human leukocyte antigen genotype (HLA-DQ2, HLA-DQ8 and HLA-DR4). APS-II affects women to a greater degree than men (75% of cases occur in women).^[2]

Features of this syndrome are:

Addison's disease^[3]
Primary hypothyroidism
Graves' disease
Pernicious anaemia
Primary hypogonadism (less common)
Diabetes mellitus (type 1)
Vitiligo (less common)
Coeliac disease
Myasthenia gravis

Symptoms

Symptoms of Addison's disease and Hashimoto's thyroiditis include:

Dry hair
Nausea
Abdominal Pain
Frequent urination^{[citation needed]}
Vomiting
Weight and muscle loss
Salt cravings / salt wasting
Anorexia and cachexia
High pulse / weakened heart
Low blood pressure
Weakness
Hypoglycemia
Numbness in extremities
Migraines / dysparunia
Poor immune system response

Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3^[4] and 4), but evidence for these distinct combinations is not convincing.^{[citation needed]}

Eponym

It is named for Hermann Adolf Alexander Schmidt (1831 – 1894), an Estonian / Baltic-German Physiologist.

References

^ Heuss D, Engelhardt A, Göbel H, Neundörfer B (June 1995). "Myopathological findings in interstitial myositis in type II polyendocrine autoimmune syndrome (Schmidt's syndrome)". Neurol. Res. 17 (3): 233–7. PMID 7643982. |access-date= requires |url= (help)
^ ^a ^b Greenspan, Francis S.; Gardner, David C. (2004). Basic clinical endocrinology. New York: McGraw-Hill. p. 103. ISBN 0-07-140297-7.
^ Betterle C, Zanchetta R (April 2003). "Update on autoimmune polyendocrine syndromes (APS)". Acta Biomed 74 (1): 9–33. PMID 12817789. |access-date= requires |url= (help)
^ de Carmo Silva R, Kater CE, Dib SA; et al. (February 2000). "Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III". Eur. J. Endocrinol. 142 (2): 187–94. doi:10.1530/eje.0.1420187. PMID 10664529. Retrieved 2008-07-25.

^ Basic Pathology - Robbins et al - 9th edition

UpToDate Contents

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1. 原発性副腎不全（アジソン病）の原因 causes of primary adrenal insufficiency addisons disease
2. 自己免疫性副腎不全の病因 pathogenesis of autoimmune adrenal insufficiency
3. 小児における原発性副腎不全の原因および臨床症状 causes and clinical manifestations of primary adrenal insufficiency in children
4. 尋常性白斑：発症機序、臨床的特徴、診断 vitiligo pathogenesis clinical features and diagnosis
5. 小児および思春期における後天性甲状腺機能低下症 acquired hypothyroidism in childhood and adolescence

English Journal

Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study.

Brenner T1, Uhle F1, Fleming T2, Wieland M1, Schmoch T1, Schmitt F1, Schmidt K1, Zivkovic AR1, Bruckner T3, Weigand MA1, Hofer S1.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.Biomarkers.2017 Feb;22(1):63-69. doi: 10.1080/1354750X.2016.1204005. Epub 2016 Jul 6.
OBJECTIVES: The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings.METHODS: Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers.RESULTS: Plasma levels of sTRE
PMID 27319606

Extracorporeal membrane oxygenation: beyond rescue therapy for acute respiratory distress syndrome?

Combes A1, Bréchot N, Luyt CE, Schmidt M.
Current opinion in critical care.Curr Opin Crit Care.2017 Feb;23(1):60-65. doi: 10.1097/MCC.0000000000000375.
PURPOSE OF REVIEW: This article summarizes the results of past and more recent series on venovenous extracorporeal membrane oxygenation (VV-ECMO) and discusses its potential indications beyond the rescue of patients with lung failure refractory to conventional mechanical ventilation.RECENT FINDINGS:
PMID 27875409

An 8-item short form of the Eating Disorder Examination-Questionnaire adapted for children (ChEDE-Q8).

Kliem S1,2, Schmidt R3, Vogel M4,5, Hiemisch A4,5, Kiess W4,5, Hilbert A3.
The International journal of eating disorders.Int J Eat Disord.2017 Jan 25. doi: 10.1002/eat.22658. [Epub ahead of print]
Eating disturbances are common in children placing a vulnerable group of them at risk for full-syndrome eating disorders and adverse health outcomes. To provide a valid self-report assessment of eating disorder psychopathology in children, a short form of the child version of the Eating Disorder Exa
PMID 28122128

Japanese Journal

Reversible Cardiomyopathy Associated with Autoimmune Polyendocrine Syndrome Type II

Karavelioglu Yusuf,Baran Ahmet,Karapinar Hekim,Küçükdurmaz Zekeriya,Yilmaz Ahmet
Internal Medicine 52(9), 981-985, 2013
… Autoimmune polyendocrine syndrome is also very rare. … We herein report a case of reversed cardiomyopathy associated with autoimmune polyendocrine syndrome type II (Schmidt's syndrome) composed of Addison's disease, vitiligo and Hashimoto's thyroiditis. … The ventricular function and size were reversed following the administration of suitable hormone replacement therapy for polyendocrine syndrome. …
NAID 130003366008

Pneumomediastinum and Striking Family History: Uncommon Case of Birt-Hogg-Dubé Syndrome

Michels Guido,Erdmann Erland,Schmidt Winfried,Frank Konrad F.,Pfister Roman
Internal Medicine 51(15), 2007-2009, 2012
… Birt-Hogg-Dubé syndrome is a rare autosomal dominant condition caused by a germline mutation in the folliculin gene, which is characterized by skin fibrofolliculomas, multiple lung cysts and renal cancer. … The clinical expression of the syndrome is highly variable, with recurrent pneumothoraces due to ruptured lung cysts in many cases. …
NAID 130002062264

多腺性自己免疫症候群 (特集ここまでわかっている自己抗体と自己免疫疾患)

石井智弘,長谷川行洋
小児科診療 73(12), 2163-2167, 2010-12
NAID 40017380236

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リンク元	「シュミット症候群」
関連記事	「syndrome」

「シュミット症候群」

Autoimmune polyendocrine syndrome type 2
Classification and external resources
Specialty	endocrinology
ICD-10	E31.0
ICD-9-CM	258.1
OMIM	269200
DiseasesDB	29690
eMedicine	med/1868
MeSH	D016884